Search Results - "Mizuno, Kazuya"

Deficiency of SHP1 leads to sustained and increased ERK activation in mast cells, thereby inhibiting IL-3-dependent proliferation and cell death by Nakata, Kazuko, Suzuki, Yoshihiro, Inoue, Toshio, Ra, Chisei, Yakura, Hidetaka, Mizuno, Kazuya

“…SHP-1 plays an important role for the regulation of signaling from various hematopoietic cell receptors. In this study, we examined IL-3-induced cell…”
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Positive and Negative Regulation of High Affinity IgE Receptor Signaling by Src Homology Region 2 Domain-Containing Phosphatase 1 by Nakata, Kazuko, Yoshimaru, Tetsuro, Suzuki, Yoshihiro, Inoue, Toshio, Ra, Chisei, Yakura, Hidetaka, Mizuno, Kazuya

“…Src homology region 2 domain-containing phosphatase 1 (SHP-1), a cytoplasmic protein tyrosine phosphatase, plays an important role for the regulation of…”
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A system for reconstructing B cell antigen receptor signaling in the mouse myeloma J558L cell line by Harumiya, Satoru, Yoshino, Aya, Hayashizaki, Koji, Mizuno, Kazuya, Yakura, Hidetaka, Adachi, Takahiro

“…► We developed a system to reconstitute BCR signaling in non-B cell line J558L. ► YC3.60 permits monitoring of BCR-mediated Ca2+ signaling. ► CD45 and CD19…”
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Negative autoregulation of Src homology region 2-domain-containing phosphatase-1 in rat basophilic leukemia-2H3 cells by Ozawa, Tomoko, Nakata, Kazuko, Mizuno, Kazuya, Yakura, Hidetaka

“…Src homology region 2-domain-containing phosphatase-1 (SHP-1) plays an important role in the regulation of signaling from various receptors in hematopoietic…”
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SHP-1 exhibits a pro-apoptotic function in antigen-stimulated mast cells: Positive regulation of mitochondrial death pathways and negative regulation of survival signaling pathways by Inoue, Toshio, Suzuki, Yoshihiro, Mizuno, Kazuya, Nakata, Kazuko, Yoshimaru, Tetsuro, Ra, Chisei

“…Src homology region 2 domain-containing phosphatase-1 (SHP-1) is known to act as a negative signal modulator in mast cells but its roles in cell survival and…”
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Dynamic regulation of Src-family kinases by CD45 in B cells by Shrivastava, Punya, Katagiri, Tatsuo, Ogimoto, Mami, Mizuno, Kazuya, Yakura, Hidetaka

“…CD45 is a key protein tyrosine phosphatase regulating Src-family protein tyrosine kinases (Src-PTKs) in lymphocytes; precisely how it exerts its effect remains…”
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Src Homology Region 2 (SH2) Domain-Containing Phosphatase-1 Dephosphorylates B Cell Linker Protein/SH2 Domain Leukocyte Protein of 65 kDa and Selectively Regulates c-Jun NH2-Terminal Kinase Activation in B Cells by Mizuno, Kazuya, Tagawa, Yuko, Mitomo, Katsuyuki, Arimura, Yutaka, Hatano, Norikazu, Katagiri, Tatsuo, Ogimoto, Mami, Yakura, Hidetaka

“…Src homology region 2 (SH2) domain-containing phosphatase-1 (SHP-1) is a cytosolic protein tyrosine phosphatase containing two SH2 domains in its NH2 terminus…”
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Selective Regulation of Lyn Tyrosine Kinase by CD45 in Immature B Cells by Katagiri, T, Ogimoto, M, Hasegawa, K, Mizuno, K, Yakura, H

“…It has been well established that protein-tyrosine phosphatase CD45 is critically involved in the regulation of initial tyrosine phosphorylation and effector…”
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CD45 Is Required for CD40-induced Inhibition of DNA Synthesis and Regulation of c-Jun NH2-terminal Kinase and p38 in BAL-17 B Cells by Arimura, Yutaka, Ogimoto, Mami, Mitomo, Katsuyuki, Katagiri, Tatsuo, Yamamoto, Ken-ichi, Volarevic, Sinisa, Mizuno, Kazuya, Yakura, Hidetaka

“…Stimulation of B cell antigen receptor (BCR) may induce proliferation, differentiation, or apoptosis, depending upon the maturational stage of the cell and the…”
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Exogenous estrogen acts differently on production of estrogen receptor in the preoptic area and the mediobasal hypothalamic nuclei in the newborn rat by Orikasa, Chitose, Mizuno, Kazuya, Sakuma, Yasuo, Hayashi, Shinji

“…Expression of the estrogen receptor (ER) in the preoptic area (POA) and the mediobasal hypothalamus (MBH) in newborn female rats was studied by…”
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Regulation of the immune system by protein tyrosine phosphatases by Mizuno, Kazuya, Yakura, Hidetaka

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Novel Mechanism for FcϵRI-mediated Signal Transducer and Activator of Transcription 5 (STAT5) Tyrosine Phosphorylation and the Selective Influence of STAT5B over Mast Cell Cytokine Production by Pullen, Nicholas A., Barnstein, Brian O., Falanga, Yves T., Wang, Zhengqi, Suzuki, Ryo, Tamang, Tenchee D. Lama, Khurana, Michele C., Harry, Emily A., Draber, Petr, Bunting, Kevin D., Mizuno, Kazuya, Wilson, Bridget S., Ryan, John J.

“…Previous studies indicate that STAT5 expression is required for mast cell development, survival, and IgE-mediated function. STAT5 tyrosine phosphorylation is…”
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Regulation of mast cell signaling by SHP-1 as a phosphatase and an adaptor (86.1) by Mizuno, Kazuya, Nakata, Kazuko, Yakura, Hidetaka

“…Abstract To clarify how SHP-1 regulates mast cell signaling, we generated BMMC from motheaten (me), viable motheaten (mev), and control (WT) mice and examined…”
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Dissection of the SHP-1 functions in FcεRI signaling (139.8) by Mizuno, Kazuya, Nakata, Kazuko, Yakura, Hidetaka

“…Abstract Although SHP-1, a cytoplasmic protein tyrosine phosphatase (PTP), is shown to be a negative modulator in hematopoietic cells, its precise molecular…”
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Insight into the mechanism of STAT5 tyrosine phosphorylation in IgE sensitized, antigen-stimulated mast cells (151.13) by Pullen, Nicholas, Barnstein, Brian, Wilson, Bridget, Falanga, Yves, Mizuno, Kazuya, Ryan, John

“…Abstract Previously we established that STAT5 expression is required for IgE-mediated mast cell function. STAT5 tyrosine phosphorylation is swiftly and…”
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Impaired learning with enhanced hippocampal long-term potentiation in PTPδ-deficient mice by Uetani, Noriko, Kato, Kunio, Ogura, Hiro, Mizuno, Kazuya, Kawano, Kano, Mikoshiba, Katsuhiko, Yakura, Hidetaka, Asano, Masahide, Iwakura, Yoichiro

“…Protein tyrosine phosphatase δ (PTPδ) is a receptor‐type PTP expressed in the specialized regions of the brain including the hippocampal CA2 and CA3, B…”
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Induction of CD45 isoform switch in murine B cells by antigen receptor stimulation and by phorbol myristate acetate and ionomycin by Ogimoto, M, Katagiri, T, Hasegawa, K, Mizuno, K, Yakura, H

“…In this study, we examined whether CD45 isoform can be switched in murine mature B cells and what signals are responsible for the process. Stimulation of…”
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Positive and negative regulation of FcεRI signaling by SHP‐1 by Mizuno, Kazuya, Nakata, Kazuko, Nakata, Hiroyasu, Yakura, Hidetaka

“…Abstract only SHP‐1 is a cytoplasmic tyrosine phosphatase and, in mast cells, has been shown to negatively regulate the initial signaling triggered by high…”
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SLP‐76 is recruited to CD22 and dephosphorylated by SHP‐1, thereby regulating B cell receptor‐induced c‐Jun N‐terminal kinase activation by Mizuno, Kazuya, Tagawa, Yuko, Watanabe, Noriyuki, Ogimoto, Mami, Yakura, Hidetaka

“…Despite the important role in the development and activation of T cells, NK cells, mast cells, and macrophages, the expression and function of SLP‐76 in B…”
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Src Homology Region 2 Domain-Containing Phosphatase 1 Positively Regulates B Cell Receptor-Induced Apoptosis by Modulating Association of B Cell Linker Protein with Nck and Activation of c-Jun NH2-Terminal Kinase by Mizuno, Kazuya, Tagawa, Yuko, Mitomo, Katsuyuki, Watanabe, Noriyuki, Katagiri, Tatsuo, Ogimoto, Mami, Yakura, Hidetaka

“…Src homology region 2 domain-containing phosphatase 1 (SHP-1) is a key mediator in lymphocyte differentiation, proliferation, and activation. We previously…”
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