Search Results - "Mizuki, Masao"

High numbers of programmed cell death-1-positive tumor infiltrating lymphocytes correlate with early onset of post-transplant lymphoproliferative disorder by Saito, Hideaki, Miyoshi, Hiroaki, Shibayama, Hirohiko, Toda, Jun, Kusakabe, Shinsuke, Ichii, Michiko, Fujita, Jiro, Fukushima, Kentaro, Maeda, Tetsuo, Mizuki, Masao, Oritani, Kenji, Seto, Masao, Yokota, Takafumi, Kanakura, Yuzuru, Hosen, Naoki, Ohshima, Koichi

“…Post-transplant lymphoproliferative disorder (PTLD) is a life-threatening complication of transplantation. In addition to reactivation of Epstein–Barr virus in…”
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Clinicopathologic characteristics of 342 patients with multicentric Castleman disease in Japan by Murakami, Miho, Johkoh, Takeshi, Hayashi, Seiji, Ohshima, Shiro, Mizuki, Masao, Nakatsuka, Shin-ichi, Tomobe, Minako, Kuroyanagi, Kazuyuki, Nakasone, Ayako, Nishimoto, Norihiro

“…Objectives: To assess the clinicopathologic features of Multicentric Castleman disease (MCD) patients in Japan. Methods: We assessed baseline data for 342…”
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Roles for deregulated receptor tyrosine kinases and their downstream signaling molecules in hematologic malignancies by Matsumura, Itaru, Mizuki, Masao, Kanakura, Yuzuru

“…Growth, survival and differentiation of hematopoietic cells are regulated by the interactions between hematopoietic growth factors and their receptors. The…”
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Tentative diagnostic criteria and disease severity classification for Castleman disease: A report of the research group on Castleman disease in Japan by Fujimoto, Shino, Koga, Tomohiro, Kawakami, Atsushi, Kawabata, Hiroshi, Okamoto, Shinichiro, Mizuki, Masao, Yano, Shingo, Ide, Makoto, Uno, Kazuko, Yagi, Katsumi, Kojima, Toshiyuki, Mizutani, Minoru, Tokumine, Yukihiro, Nishimoto, Norihiro, Fujiwara, Hiroshi, Nakatsuka, Shin-ichi, Shiozawa, Kazuko, Iwaki, Noriko, Masaki, Yasufumi, Yoshizaki, Kazuyuki

“…Objectives: To determine the tentative diagnostic criteria and disease severity classification for Castleman disease (CD) and describe the clinical and…”
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Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations by Mizuki, Masao, Schwäble, Joachim, Steur, Claudia, Choudhary, Chunaram, Agrawal, Shuchi, Sargin, Bülent, Steffen, Björn, Matsumura, Itaru, Kanakura, Yuzuru, Böhmer, Frank D., Müller-Tidow, Carsten, Berdel, Wolfgang E., Serve, Hubert

“…The receptor tyrosine kinase Flt3 is expressed and functionally important in early myeloid progenitor cells and in the majority of acute myeloid leukemia (AML)…”
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The Scaffolding Adapter Gab2, via Shp-2, Regulates Kit-evoked Mast Cell Proliferation by Activating the Rac/JNK Pathway by Yu, Min, Luo, Jincai, Yang, Wentian, Wang, Yongping, Mizuki, Masao, Kanakura, Yuzuru, Besmer, Peter, Neel, Benjamin G., Gu, Haihua

“…The scaffolding adapter Gab2 mediates cell signaling and responses evoked by various extracellular stimuli including several growth factors. Kit, the receptor…”
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Roles for c-Myc in Self-renewal of Hematopoietic Stem Cells by Satoh, Yusuke, Matsumura, Itaru, Tanaka, Hirokazu, Ezoe, Sachiko, Sugahara, Hiroyuki, Mizuki, Masao, Shibayama, Hirohiko, Ishiko, Eri, Ishiko, Jun, Nakajima, Koichi, Kanakura, Yuzuru

“…Notch and HOXB4 have been reported to expand hematopoietic stem cells (HSCs) in vitro. However, their critical effector molecules remain undetermined. We found…”
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The development history and future perspective of molecularly targeted therapy by Mizuki, Masao, Kanakura, Yuzuru

“…The origin of molecularly targeted drugs dates back to 'magic bullet' theory proposed by Paul Ehrlich. The success of Abl tyrosine kinase inhibitor, imatinib…”
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AML1/RUNX1 Works as a Negative Regulator of c-Mpl in Hematopoietic Stem Cells by Satoh, Yusuke, Matsumura, Itaru, Tanaka, Hirokazu, Ezoe, Sachiko, Fukushima, Kentaro, Tokunaga, Masahiro, Yasumi, Masato, Shibayama, Hirohiko, Mizuki, Masao, Era, Takumi, Okuda, Tsukasa, Kanakura, Yuzuru

“…In this study, we analyzed the roles for AML1/RUNX1 in the regulation of the c-mpl promoter. Wild-type AML1 activated the c-mpl promoter through the proximal…”
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Managing hepatitis B virus carriers with systemic chemotherapy or biologic therapy in the outpatient clinic by Nishida, Tsutomu, Hiramatsu, Naoki, Mizuki, Masao, Nagatomo, Izumi, Kida, Hiroshi, Tazumi, Keiko, Shinzaki, Shinichiro, Miyazaki, Masanori, Yakushijin, Takayuki, Tatsumi, Tomohide, Iijima, Hideki, Kiso, Shinichi, Kanto, Tatsuya, Tsujii, Masahiko, Takehara, Tetsuo

“…Aim:  The number of outpatients receiving systemic chemotherapy in Japan has recently increased. We retrospectively examined whether hepatitis B virus (HBV)…”
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Notch Signals Inhibit the Development of Erythroid/Megakaryocytic Cells by Suppressing GATA-1 Activity through the Induction of HES1 by Ishiko, Eri, Matsumura, Itaru, Ezoe, Sachiko, Gale, Karin, Ishiko, Jun, Satoh, Yusuke, Tanaka, Hirokazu, Shibayama, Hirohiko, Mizuki, Masao, Era, Takumi, Enver, Tariq, Kanakura, Yuzuru

“…The effects of Notch signals on the erythroid/megakaryocytic differentiation of hematopoietic cells were examined. Activation of Notch signals by the…”
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Pathogenesis, diagnosis and treatment of mastocytosis by Mizuki, Masao, Kanakura, Yuzuru

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Functional Cooperation among Ras, STAT5, and Phosphatidylinositol 3-Kinase Is Required for Full Oncogenic Activities of BCR/ABL in K562 Cells by Sonoyama, Junko, Matsumura, Itaru, Ezoe, Sachiko, Satoh, Yusuke, Zhang, Xian, Kataoka, Yoshihisa, Takai, Emi, Mizuki, Masao, Machii, Takashi, Wakao, Hiroshi, Kanakura, Yuzuru

“…BCR/ABL tyrosine kinase generated from the chromosomal translocation t(9;22) causes chronic myelogenous leukemia and acute lymphoblastic leukemia. To examine…”
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Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor–induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration by Ueda, Shuji, Mizuki, Masao, Ikeda, Hirokazu, Tsujimura, Tohru, Matsumura, Itaru, Nakano, Kazushi, Daino, Hanako, Honda, Zen-ichiro, Sonoyama, Junko, Shibayama, Hirohiko, Sugahara, Hiroyuki, Machii, Takashi, Kanakura, Yuzuru

“…Stem cell factor (SCF) has crucial roles in proliferation, survival, and differentiation of hematopoietic stem cells and mast cells through binding to c-Kit…”
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Effect of the administration of zoledronic acid on life expectancy in patients with multiple myeloma with or without renal impairment by Morio, Kayoko, Tsugane, Mamiko, Mizuki, Masao, Uejima, Etsuko

“…Zoledronic acid(ZA)is believed to exert anticancer effects in patients with multiple myeloma(MM). For patients with impaired renal function, its dosage should…”
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Enhanced production of osteopontin in multiple myeloma: clinical and pathogenic implications by Saeki Mima, Yukihiko, Toru, Ishii, Taeko, Ogata, Atsushi, Kobayashi, Hideyuki, Ohshima, Shiro, Ishida, Tetsushi, Tabunoki, Yuichiro, Kitayama, Hitoshi, Mizuki, Masao, Katada, Yoshinori, Asaoku, Hideki, Kitano, Masayasu, Nishimoto, Norihiro, Yoshizaki, Kazuyuki, Maeda, Masahiro, Kon, Shigeyuki, Kinoshita, Naokazu, Uede, Toshimitsu, Kawase, Ichiro

“…In this study, we examined osteopontin (OPN) production in myeloma cells and plasma OPN levels in multiple myeloma (MM) patients. We assessed OPN production in…”
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Distinct role for c-kit receptor tyrosine kinase and SgIGSF adhesion molecule in attachment of mast cells to fibroblasts by KOMA, Yu-Ichiro, ITO, Akihiko, WATABE, Kenji, HIRATA, Tatsumi, MIZUKI, Masao, YOKOZAKI, Hiroshi, KITAMURA, Toshio, KANAKURA, Yuzuru, KITAMURA, Yukihiko

“…Binding of stem cell factor (SCF) to c-kit receptor tyrosine kinase (KIT) transduces signals essential for mast cell development via several pathways including…”
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GATA Transcription Factors Inhibit Cytokine-dependent Growth and Survival of a Hematopoietic Cell Line through the Inhibition of STAT3 Activity by Ezoe, Sachiko, Matsumura, Itaru, Gale, Karin, Satoh, Yusuke, Ishikawa, Jun, Mizuki, Masao, Takahashi, Satoru, Minegishi, Naoko, Nakajima, Koichi, Yamamoto, Masayuki, Enver, Tariq, Kanakura, Yuzuru

“…Although GATA-1 and GATA-2 were shown to be essential for the development of hematopoietic cells by gene targeting experiments, they were also reported to…”
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Establishment and characterization of unique cell lines derived from pyothorax‐associated lymphoma which develops in long‐standing pyothorax and is strongly associated with Epstein‐Barr virus infection by Takakuwa, Tetsuya, Luo, Wen‐Juan, Ham, Maria Francisca, Mizuki, Masao, Iuchi, Keiji, Aozasa, Katsuyuki

“…Malignant lymphoma frequently develops in the pleural cavity of patients with over 20 years' history of pyothorax. The term pyothorax‐associated lymphoma (PAL)…”
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Roles of tyrosine residues 845, 892 and 922 in constitutive activation of murine FLT3 kinase domain mutant by ISHIKO, Jun, MIZUKI, Masao, MATSUMURA, Itaru, SHIBAYAMA, Hirohiko, SUGAHARA, Hiroyuki, SCHOLZ, Glen, SERVE, Hubert, KANAKURA, Yuzuru

“…FLT3 tyrosine kinase domain (TKD) mutations are detected in approximately 7% of acute myeloid leukemia patients, and suggested to correlate with poor prognosis…”
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