Search Results - "Mizukami, Jun"
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Lead generation and optimization of novel GPR119 agonists with a spirocyclic cyclohexane structure
Published in Bioorganic & medicinal chemistry letters (01-02-2019)“…[Display omitted] We describe here the generation of a lead compound and its optimization studies that led to the identification of a novel GPR119 agonist…”
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Design and synthesis of novel and potent GPR119 agonists with a spirocyclic structure
Published in Bioorganic & medicinal chemistry letters (15-04-2018)“…[Display omitted] Exploration of alternative structures of the substituted piperidine or piperazine ring which are characteristic in most of the reported…”
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Optimization of oxadiazole derivatives with a spirocyclic cyclohexane structure as novel GPR119 agonists
Published in Bioorganic & medicinal chemistry letters (15-08-2019)“…[Display omitted] We describe here a novel GPR119 agonist 24, which showed a potent and long-acting hypoglycemic effect in rats via oral dosing. For the…”
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Synthesis of Helicenediamine Oligomers and Their Formation of Multilayer Structures in Aqueous Solvents
Published in Bulletin of the Chemical Society of Japan (01-02-2006)“…Optically active polyamine oligomers containing three to six (P)-5,8-bis(aminomethyl)-1,12-dimethylbenzo[c]phenanthrenes were synthesized employing the…”
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