Search Results - "Mizuguchi, Chiharu"

Two-step FRET as a tool for probing the amyloid state of proteins by Gorbenko, Galyna, Trusova, Valeriya, Deligeorgiev, Todor, Gadjev, Nikolai, Mizuguchi, Chiharu, Saito, Hiroyuki

“…Amyloid fibrils, a special class of protein aggregates with a core β-sheet structure, are currently associated with a number of human disorders. The…”
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Phosphatidylethanolamine accelerates aggregation of the amyloidogenic N‐terminal fragment of apoA‐I by Kurimitsu, Naoko, Mizuguchi, Chiharu, Fujita, Kaho, Taguchi, Suzuno, Ohgita, Takashi, Nishitsuji, Kazuchika, Shimanouchi, Toshinori, Saito, Hiroyuki

“…Membrane lipid composition is known to influence aggregation and fibril formation of many amyloidogenic proteins. Here, we found that phosphatidylethanolamine…”
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Mechanisms of aggregation and fibril formation of the amyloidogenic N-terminal fragment of apolipoprotein A-I by Mizuguchi, Chiharu, Nakagawa, Miho, Namba, Norihiro, Sakai, Misae, Kurimitsu, Naoko, Suzuki, Ayane, Fujita, Kaho, Horiuchi, Sayaka, Baba, Teruhiko, Ohgita, Takashi, Nishitsuji, Kazuchika, Saito, Hiroyuki

“…The N-terminal (1–83) fragment of the major constituent of plasma high-density lipoprotein, apolipoprotein A-I (apoA-I), strongly tends to form amyloid…”
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Fluorescence study of the effect of the oxidized phospholipids on amyloid fibril formation by the apolipoprotein A-I N-terminal fragment by Vus, Kateryna, Girych, Mykhailo, Trusova, Valeriya, Gorbenko, Galyna, Kinnunen, Paavo, Mizuguchi, Chiharu, Saito, Hiroyuki

“…[Display omitted] •Oxidative stress plays a critical role in Alzheimer’s, Parkinson’s diseases, etc.•Apolipoprotein A-I (ApoA-I) G26R mutation is associated…”
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Heparin promotes fibril formation by the N‐terminal fragment of amyloidogenic apolipoprotein A‐I by Mikawa, Shiho, Mizuguchi, Chiharu, Nishitsuji, Kazuchika, Baba, Teruhiko, Shigenaga, Akira, Shimanouchi, Toshinori, Sakashita, Naomi, Otaka, Akira, Akaji, Kenichi, Saito, Hiroyuki

“…Glycosaminoglycans are known to be associated with extracellular amyloid deposits of various amyloidogenic proteins. In this study, we found that the…”
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The extreme N-terminal region of human apolipoprotein A-I has a strong propensity to form amyloid fibrils by Adachi, Emi, Kosaka, Asako, Tsuji, Kohei, Mizuguchi, Chiharu, Kawashima, Hiroyuki, Shigenaga, Akira, Nagao, Kohjiro, Akaji, Kenichi, Otaka, Akira, Saito, Hiroyuki

“…•The N-terminal 1–83 residues of apoA-I have a propensity to form amyloid fibrils.•ApoA-I 1–43 peptide forms amyloid fibrils with transition to β-sheet-rich…”
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Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes by Mizuguchi, Chiharu, Ogata, Fuka, Mikawa, Shiho, Tsuji, Kohei, Baba, Teruhiko, Shigenaga, Akira, Shimanouchi, Toshinori, Okuhira, Keiichiro, Otaka, Akira, Saito, Hiroyuki

“…The N-terminal amino acid 1–83 fragment of apolipoprotein A-I (apoA-I) has a strong propensity to form amyloid fibrils at physiological neutral pH. Because…”
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Influence of Domain Stability on the Properties of Human Apolipoprotein E3 and E4 and Mouse Apolipoprotein E by Nguyen, David, Dhanasekaran, Padmaja, Nickel, Margaret, Mizuguchi, Chiharu, Watanabe, Mayu, Saito, Hiroyuki, Phillips, Michael C, Lund-Katz, Sissel

“…The human apolipoprotein (apo) E4 isoform, which differs from wild-type apoE3 by the single amino acid substitution C112R, is associated with elevated risk of…”
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Lipid Bilayer Interactions of Amyloidogenic N-Terminal Fragment of Apolipoprotein A-I Probed by Förster Resonance Energy Transfer and Molecular Dynamics Simulations by Gorbenko, Galyna P., Trusova, Valeriya, Mizuguchi, Chiharu, Saito, Hiroyuki

“…The effects of one of the amyloidogenic mutations of apolipoprotein A-I (apoA-I), G26R, on the thermal stability, structural dynamics and lipid-associating…”
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Fluorescence study of domain structure and lipid interaction of human apolipoproteins E3 and E4 by Mizuguchi, Chiharu, Hata, Mami, Dhanasekaran, Padmaja, Nickel, Margaret, Okuhira, Keiichiro, Phillips, Michael C., Lund-Katz, Sissel, Saito, Hiroyuki

“…Human apolipoprotein E (apoE) isoforms exhibit different conformational stabilities and lipid-binding properties that give rise to altered cholesterol…”
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FRET evidence for untwisting of amyloid fibrils on the surface of model membranes by Gorbenko, Galyna, Trusova, Valeriya, Girych, Mykhailo, Adachi, Emi, Mizuguchi, Chiharu, Akaji, Kenichi, Saito, Hiroyuki

“…Apolipoprotein A-I (apoA-I) is an amyloid-forming protein whose amyloidogenic properties are attributed mainly to its N-terminal fragment. Cell membranes are…”
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Fluorescence Analysis of the Lipid Binding-Induced Conformational Change of Apolipoprotein E4 by Mizuguchi, Chiharu, Hata, Mami, Dhanasekaran, Padmaja, Nickel, Margaret, Phillips, Michael C, Lund-Katz, Sissel, Saito, Hiroyuki

“…Apolipoprotein (apo) E is thought to undergo conformational changes in the N-terminal helix bundle domain upon lipid binding, modulating its receptor binding…”
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Immunochemical Approach for Monitoring of Structural Transition of ApoA-I upon HDL Formation Using Novel Monoclonal Antibodies by Kimura, Hitoshi, Mikawa, Shiho, Mizuguchi, Chiharu, Horie, Yuki, Morita, Izumi, Oyama, Hiroyuki, Ohgita, Takashi, Nishitsuji, Kazuchika, Takeuchi, Atsuko, Lund-Katz, Sissel, Akaji, Kenichi, Kobayashi, Norihiro, Saito, Hiroyuki

“…Apolipoprotein A-I (apoA-I) undergoes a large conformational reorganization during remodeling of high-density lipoprotein (HDL) particles. To detect structural…”
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Membrane Effects of N-Terminal Fragment of Apolipoprotein A-I: A Fluorescent Probe Study by Trusova, Valeriya, Gorbenko, Galyna, Girych, Mykhailo, Adachi, Emi, Mizuguchi, Chiharu, Sood, Rohit, Kinnunen, Paavo, Saito, Hiroyuki

“…The binding of monomeric and aggregated variants of 1–83 N-terminal fragment of apolipoprotein A-I with substitution mutations G26R, G26R/W@8, G26R/W@50 and…”
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Dual Role of an N-terminal Amyloidogenic Mutation in Apolipoprotein A-I by Adachi, Emi, Nakajima, Hiroyuki, Mizuguchi, Chiharu, Dhanasekaran, Padmaja, Kawashima, Hiroyuki, Nagao, Kohjiro, Akaji, Kenichi, Lund-Katz, Sissel, Phillips, Michael C., Saito, Hiroyuki

“…A number of naturally occurring mutations of apolipoprotein (apo) A-I, the major protein of HDL, are known to be associated with hereditary amyloidosis and…”
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Dual role of an N-terminal amyloidogenic mutation in apolipoprotein A-I: destabilization of helix bundle and enhancement of fibril formation by Adachi, Emi, Nakajima, Hiroyuki, Mizuguchi, Chiharu, Dhanasekaran, Padmaja, Kawashima, Hiroyuki, Nagao, Kohjiro, Akaji, Kenichi, Lund-Katz, Sissel, Phillips, Michael C, Saito, Hiroyuki

“…A number of naturally occurring mutations of apolipoprotein (apo) A-I, the major protein of HDL, are known to be associated with hereditary amyloidosis and…”
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Interactions of Apolipoprotein A‑I with High-Density Lipoprotein Particles by Nguyen, David, Nickel, Margaret, Mizuguchi, Chiharu, Saito, Hiroyuki, Lund-Katz, Sissel, Phillips, Michael C

“…Although the partitioning of apolipoprotein A-I (apoA-I) molecules in plasma between high-density lipoprotein (HDL)-bound and -unbound states is an integral…”
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Interaction of Thioflavin T with amyloid fibrils of apolipoprotein A-I N-terminal fragment: Resonance energy transfer study by Girych, Mykhailo, Gorbenko, Galyna, Trusova, Valeriya, Adachi, Emi, Mizuguchi, Chiharu, Nagao, Kohjiro, Kawashima, Hiroyuki, Akaji, Kenichi, Lund-Katz, Sissel, Phillips, Michael C., Saito, Hiroyuki

“…Apolipoprotein A-I is amenable to a number of specific mutations associated with hereditary systemic amyloidoses. Amyloidogenic properties of apoA-I are…”
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Conformational plasticity of JRAB/MICAL-L2 provides "law and order" in collective cell migration by Sakane, Ayuko, Yoshizawa, Shin, Nishimura, Masaomi, Tsuchiya, Yuko, Matsushita, Natsuki, Miyake, Kazuhisa, Horikawa, Kazuki, Imoto, Issei, Mizuguchi, Chiharu, Saito, Hiroyuki, Ueno, Takato, Matsushita, Sachi, Haga, Hisashi, Deguchi, Shinji, Mizuguchi, Kenji, Yokota, Hideo, Sasaki, Takuya

“…In fundamental biological processes, cells often move in groups, a process termed collective cell migration. Collectively migrating cells are much better…”
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Effect of Phosphatidylserine and Cholesterol on Membrane-mediated Fibril Formation by the N-terminal Amyloidogenic Fragment of Apolipoprotein A-I by Mizuguchi, Chiharu, Nakamura, Mitsuki, Kurimitsu, Naoko, Ohgita, Takashi, Nishitsuji, Kazuchika, Baba, Teruhiko, Shigenaga, Akira, Shimanouchi, Toshinori, Okuhira, Keiichiro, Otaka, Akira, Saito, Hiroyuki

“…Here, we examined the effects of phosphatidylserine (PS) and cholesterol on the fibril-forming properties of the N-terminal 1‒83 fragment of an amyloidogenic…”
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