Search Results - "Mizsak, S A"

Biosynthesis of the Pipecolate Moiety of Marcfortine A by Kuo, M. S, Yurek, D. A, Mizsak, S. A, Cialdella, J. I, Baczynskyj, L, Marshall, V. P

“…In this paper, we demonstrate that the marcfortine A (MA) producing Penicillium strain incorporates l-lysine, which is metabolized to the pipecolate moiety by…”
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Solution structures of stromelysin complexed to thiadiazole inhibitors by Stockman, Brian J., Waldon, Daniel J., Gates, Jo A., Scahill, Terrence A., Kloosterman, David A., Mizsak, Stephen A., Jacobsen, E. Jon, Belonga, Kenneth L., Mitchell, Mark A., Mao, Boryeu, Petke, James D., Goodman, Linda, Powers, Elaine A., Ledbetter, Steven R., Kaytes, Paul S., Vogeli, Gabriel, Marshall, Vincent P., Petzold, Gary L., Poorman, Roger A.

“…Unregulated or overexpressed matrix metalloproteinases (MMPs), including stromelysin, collagenase, and gelatinase, have been implicated in several pathological…”
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Synthesis and biological activity of spirocyclic benzopyran imidazolone potassium channel openers by Gadwood, Robert C, Kamdar, Bharat V, Dubray, Loretta A. Cipkus, Wolfe, Mark L, Smith, Michael P, Watt, William, Mizsak, Stephen A, Groppi, Vincent E

“…A series of novel spirocyclic benzopyran imidazolones were synthesized as rigid analogues of cromakalim. These compounds cause a dose-dependent membrane…”
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The structure of CC-1065, a potent antitumor agent and its binding to DNA by Chidester, C. G, Krueger, W. C, Mizsak, S. A, Duchamp, D. J, Martin, D. G

“…The crystal and molecular structure of a potent antitumor agent, CC-1065 (C sub(35)H sub(33)N sub(7)O sub(8)), has been determined, and circular dichoism…”
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Syntheses of benzoquinolizidine and benzoindolizidine derivatives as anti-amnesic agents by SHIKAI ZHAO, TOTLEBEN, M. J, MIZSAK, S. A, SZMUSZKOVICZ, J, FREEMAN, J. P, BACON, C. L, FOX, G. B, O'DRISCOLL, E, FOLEY, A. G, KELLY, J, FARRELL, U, REGAN, C

“…Tacrine, one of the drugs available for Alzheimer's disease based on the cholinergic approach, suffers from considerable toxicity. Many analogues of tacrine…”
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In vitro metabolic transformations of 2,4-dipyrrolidinylpyrimidine: a chemical probe for P450-mediated oxidation of tirilazad mesylate by STREEPER, R. T, PEARSON, P. G, ZHAO, Z, MIZSAK, S. A, SANDERS, P. E, WIENKERS, L. C, VRBANAC, J. J

“…1. We have determined that 2,4-dipyrrolidinylpyrimidine (2,4-DPP), used as a model for studies of the metabolism of therapeutic agents containing this moiety,…”
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Isolation and identification of a major metabolite of PNU-107859, an MMP inhibitor from the biliary fluid of rats by Kuo, M S, Yurek, D A, Mizsak, S A, Prairie, M D, Mattern, S J, DeKoning, T F

“…PNU-107859, an important representative structure in a novel class of matrix metalloproteinases (MMP) inhibitors known as thiadiazoles, was found to be quickly…”
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Syntheses of 1,2-diamino and 1,2-aminoalcohol derivatives in the piperidine and pyrrolidine series as anti-amnesic agents by SHIKAI ZHAO, FREEMAN, J. P, SZMUSZKOVICZ, J, BACON, C. L, FOX, G. B, O'DRISCOLL, E, FOLEY, A. G, KELLY, J, FARRELL, U, REGAN, C, MIZSAK, S. A

“…Tacrine, one of the drugs available for Alzheimer's disease based on the cholinergic approach, suffers from considerable toxicity. Many analogues of tacrine…”
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Discovery of an arachidonic acid C-8 lipoxygenase in the gorgonian coral Pseudoplexaura porosa by Bundy, G L, Nidy, E G, Epps, D E, Mizsak, S A, Wnuk, R J

“…The gorgonian coral Pseudoplexaura porosa contains a lipoxygenase capable of converting exogenous arachidonic acid into…”
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Structure of CC-1065 (NSC-298223), a new antitumor antibiotic by Martin, D G, Chidester, C G, Duchamp, D J, Mizsak, S A

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New paulomycins produced by Streptomyces paulus by Argoudelis, A D, Baczynskyj, L, Haak, W J, Knoll, W M, Mizsak, S A, Shilliday, F B

“…Paulomycin A2 (C34H46N2O17S), paulomycin C (C32H42N2O17S), paulomycin D (C31H40N2O17S), paulomycin E (C29H36N2O16S) and paulomycin F (C29H38N2O16S) have been…”
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Structural relationships between senfolomycins and paulomycins by Argoudelis, A D, Baczynskyj, L, Mizsak, S A, Shilliday, F B, Wiley, P F

“…Senfolomycins A and B (Antimicrob. Agents Chemother.-1965: 828-831, 1966) are two antibacterial agents with physico-chemical and biological properties similar…”
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Adenylylation of trospectomycin by crude enzyme preparations from Escherichia coli by Yagi, Y, Baczynskyj, L, Mizsak, S A, Argoudelis, A D

“…Employing osmotically shocked lysate of a spectinomycin resistant strain of Escherichia coli, trospectomycin, a new alkylspectinomycin, was adenylylated in the…”
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O-demethylpaulomycins A and B, U-77,802 and U-77,803, paulomenols A and B, new metabolites produced by Streptomyces paulus by Argoudelis, A D, Baczynskyj, L, Mizsak, S A, Shilliday, F B

“…O-Demethylpaulomycin A (C33H44N2O17S), O-demethylpaulomycin B (C32H42N2O17S), paulomenol A (C29H43NO16), paulomenol B (C28H41NO16), and the hydrogen sulfide…”
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Paulomycin-related antibiotics: paldimycins and antibiotics 273a2. Isolation and characterization by Argoudelis, A D, Baczynskyj, L, Buege, J A, Marshall, V P, Mizsak, S A, Wiley, P F

“…The isolation of paulomycins A and B from fermentations of Streptomyces paulus has been reported earlier [J. Antibiotics 35: 285-294, 1982]. Further work on…”
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Synthesis of Novel 2,4-Diaminopyrrolo[2,3-d]pyrimidines with Antioxidant, Neuroprotective, and Antiasthma Activity by Bundy, Gordon L, Ayer, Donald E, Banitt, Lee S, Belonga, Kenneth L, Mizsak, Stephen A, Palmer, John R, Tustin, James M, Chin, Jia En, Hall, Edward D

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Desertomycin: purification and physical-chemical properties by Dolak, L A, Reusser, F, Baczynskyj, L, Mizsak, S A, Hannon, B R, Castle, T M

“…Desertomycin was isolated from Streptomyces macronensis Dietz sp. nov. UC 8271. Extensive spectroscopic work led us to place desertomycin in the macrocyclic…”
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Isolation and characterization of a new antibiotic U-62162 by Slechta, L, Cialdella, J I, Mizsak, S A, Hoeksema, H

“…A new antibiotic U-62162 has been isolated from the fermentations of Streptomyces verdensis Dietz, sp. n. (UC-8157). The compound has been characterized and…”
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Structure elucidation of ficellomycin by Kuo, M S, Yurek, D A, Mizsak, S A

“…The structure of ficellomycin, an antibiotic previously discovered by Argoudelis et al., is elucidated as…”
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Paulomycins A and B. Isolation and characterization by Argoudelis, A D, Brinkley, T A, Brodasky, T F, Buege, J A, Meyer, H F, Mizsak, S A

“…Paulomycin A, C34H46N2O17S and paulomycin B, C33H44N2O17S are two antibiotics produced by Streptomyces paulus strain 273 (UC 5142). Both antibiotics, which are…”
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