Search Results - "Mizoue, Kazutoshi"

Cloning and Characterization of the Biosynthetic Gene Cluster of 16-Membered Macrolide Antibiotic FD-891: Involvement of a Dual Functional Cytochrome P450 Monooxygenase Catalyzing Epoxidation and Hydroxylation by Kudo, Fumitaka, Motegi, Atsushi, Mizoue, Kazutoshi, Eguchi, Tadashi

“…FD-891 is a 16-membered cytotoxic antibiotic macrolide that is especially active against human leukemia such as HL-60 and Jurkat cells. We identified the…”
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Cloning of the biosynthetic gene cluster for naphthoxanthene antibiotic FD-594 from Streptomyces sp. TA-0256 by Kudo, Fumitaka, Yonezawa, Takanori, Komatsubara, Akiko, Mizoue, Kazutoshi, Eguchi, Tadashi

“…FD-594 is an unique pyrano[4′,3′:6,7]naphtho[1,2-b]xanthene polyketide with a trisaccharide of 2,6-dideoxysugars. In this study, we cloned the FD-594…”
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Total synthesis and determination of the absolute configuration of FD-838, a naturally occurring azaspirobicyclic product by Hayashi, Yujiro, Sankar, Kuppusamy, Ishikawa, Hayato, Nozawa, Yuriko, Mizoue, Kazutoshi, Kakeya, Hideaki

“…First asymmetric total synthesis of FD-838, a naturally occurring azaspirobicyclic product, has been accomplished allowing determination of its absolute…”
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Structural basis of inhibition of cysteine proteases by E-64 and its derivatives by Matsumoto, Keita, Mizoue, Kazutoshi, Kitamura, Kunihiro, Tse, Wai-Ching, Huber, Carol P., Ishida, Toshimasa

“…This paper focuses on the inhibitory mechanism of E‐64 and its derivatives (epoxysuccinyl‐based inhibitors) with some cysteine proteases, based on the binding…”
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The cytotoxic macrolide FD-891 induces caspase-8-dependent mitochondrial release of cytochrome c and subsequent apoptosis in human leukemia Jurkat cells by Inaba, Susumu, Eguchi, Tadashi, Motegi, Atsushi, Mizoue, Kazutoshi, Usui, Takeo, Nagai, Kazuo, Kataoka, Takao

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Structure revision of FD-891, a 16-membered macrolide antibiotic by Eguchi, Tadashi, Yamamoto, Keita, Mizoue, Kazutoshi, Kakinuma, Katsumi

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Stereostructure of a Novel Cytotoxic 18-Membered Macrolactone Antibiotic FD-891 by Eguchi, Tadashi, Kobayashi, Kayako, Uekusa, Hidehiro, Ohashi, Yuji, Mizoue, Kazutoshi, Matsushima, Yoshitaka, Kakinuma, Katsumi

“…The absolute stereochemistry of FD-891, a novel cytotoxic 18-membered macrolactone antibiotic, was determined by a synthetic approach as well as X-ray…”
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A novel neuritogenic compound, NGA0187 by Nozawa, Yuriko, Sakai, Noriyoshi, Matsumoto, Keita, Mizoue, Kazutoshi

“…A new neuritogenic compound NGA0187 was isolated from the fermentation broth of Acremonium sp. TF-0356. The structure of NGA0187 was determined by means of…”
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Isolation and characterization of a new pyrano[4',3':6,7]naphtho[1,2-b]xanthene antibiotic FD-594 by Qiao, Y F, Okazaki, T, Ando, T, Mizoue, K

“…During our screening of microbial metabolites for effective drugs against tumor cell lines, we discovered a new pyrano[4',3':6,7]naphtho[1,2-b]xanthene…”
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Cytotoxic Cardenolides from Woods of Euonymus alata by KITANAKA, Susumu, TAKIDO, Michio, MIZOUE, Kazutoshi, NAKAIKE, Shiro

“…Three cytotoxic cardenolides, acovenosigenin A 3-O-α-L-ramnopyranoside (1), euonymoside A (2) and euonymusoside A (3), were isolated from the woods of Euonymus…”
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Stachybotrin C and parvisporin, novel neuritogenic compounds. II. Structure determination by Nozawa, Y, Ito, M, Sugawara, K, Hanada, K, Mizoue, K

“…The structures of stachybotrin C and parvisporin have been determined by spectroscopic analyses and chemical derivatization. Stachybotrin C contains a unique…”
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Synthesis of NG-061 and Its Analogs, and Their Biological Evaluation as an Enhancer of Nerve Growth Factor by EGUCHI, Tadashi, KANAI, Shinobu, KAKINUMA, Katsumi, OKAZAKI, Tadayasu, MIZOUE, Kazutoshi

“…A novel potentiator of nerve growth factor (NGF), NG-061, which had been isolated from the fermentation broth of Penicillium minioluteum F-4627, was…”
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Structure and biosynthesis of FD-594; a new antitumor antibiotic by Kondo, K, Eguchi, T, Kakinuma, K, Mizoue, K, Qiao, Y F

“…The structure of a novel antitumor antibiotics FD-594 (1), produced by Streptomyces sp. TA-0256, was determined to have a glycosylated…”
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Microbial glycosylation of macrolide antibiotics by Streptomyces hygroscopicus ATCC 31080 and distribution of a macrolide glycosyl transferase in several Streptomyces strains by Sasaki, J, Mizoue, K, Morimoto, S, Omura, S

“…In the course of our microbial transformation study on erythromycin derivatives, Streptomyces hygroscopicus ATCC 31080, which produces a polyether antibiotic…”
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A novel fungal metabolite NG-061 enhances and mimics neurotrophic effect of nerve growth factor (NGF) on neurite outgrowth in PC12 cells by Ito, M, Sakai, N, Ito, K, Mizobe, F, Hanada, K, Mizoue, K

“…During the course of our screening program for low molecular natural products with their ability to potentiate and/or mimic neurotrophic effect of NGF, a novel…”
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Stachybotrin C and parvisporin, novel neuritogenic compounds. I. Taxonomy, isolation, physico-chemical and biological properties by Nozawa, Y, Yamamoto, K, Ito, M, Sakai, N, Mizoue, K, Mizobe, F, Hanada, K

“…Stachybotrin C and parvisporin, novel neuritogenic compounds, were isolated from the culture broth of Stachybotrys parvispora F4708. Stachybotrin C induced…”
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Waol B, a new trihydrofuran derivative with cytocidal activity, isolated from Myceliophthora lutea by Nozawa, O, Okazaki, T, Morimoto, S, Chen, Z X, He, B M, Mizoue, K

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Oligomeric Stilbenes from Caragana chamlagu LAMARK Root by KITANAKA, Susumu, TAKIDO, Michio, MIZOUE, Kazutoshi, KONDO, Hideki, NAKAIKE, Shiro

“…Caraganaphenol A (1), a new tetrameric stibene, was isolated from the root of Caragana chamlagu LAMARK (Leguminosae) along with (+)-α-viniferin (2) and…”
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Structure of NG-061, a novel potentiator of nerve growth factor (NGF) isolated from Penicillium minioluteum F-4627 by Bhandari, R, Eguchi, T, Sekine, A, Ohashi, Y, Kakinuma, K, Ito, M, Mizoue, K

“…The structure of NG-061, a new potentiator of nerve growth factor (NGF) isolated from Penicillium minioluteum F-4627, was determined by spectroscopic analysis…”
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Isolation and characterization of new 18-membered macrolides FD-891 and FD-892 by Seki-Asano, M, Okazaki, T, Yamagishi, M, Sakai, N, Hanada, K, Mizoue, K

“…New 18-membered macrolides FD-891 and FD-892 were discovered from the fermentation broth of Streptomyces graminofaciens A-8890 isolated from a soil sample…”
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