Search Results - "Mizokami, Atsushi"

Macrophage Polarity and Disease Control by Kadomoto, Suguru, Izumi, Kouji, Mizokami, Atsushi

“…Macrophages are present in most human tissues and have very diverse functions. Activated macrophages are usually divided into two phenotypes, M1 macrophages…”
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The CCL20-CCR6 Axis in Cancer Progression by Kadomoto, Suguru, Izumi, Kouji, Mizokami, Atsushi

“…Chemokines, which are basic proteins that exert their effects via G protein-coupled receptors and a subset of the cytokine family, are mediators deeply…”
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Roles of CCL2-CCR2 Axis in the Tumor Microenvironment by Kadomoto, Suguru, Izumi, Kouji, Mizokami, Atsushi

“…Chemokines are a small family of cytokines that were first discovered as chemotactic factors in leukocytes during inflammation, and reports on the relationship…”
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Is the C-C Motif Ligand 2-C-C Chemokine Receptor 2 Axis a Promising Target for Cancer Therapy and Diagnosis? by Iwamoto, Hiroaki, Izumi, Kouji, Mizokami, Atsushi

“…C-C motif ligand 2 (CCL2) was originally reported as a chemical mediator attracting mononuclear cells to inflammatory tissue. Many studies have reported that…”
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Testosterone and Bone Health in Men: A Narrative Review by Shigehara, Kazuyoshi, Izumi, Kouji, Kadono, Yoshifumi, Mizokami, Atsushi

“…Bone fracture due to osteoporosis is an important issue in decreasing the quality of life for elderly men in the current aging society. Thus, osteoporosis and…”
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Bone scan index: A new biomarker of bone metastasis in patients with prostate cancer by Nakajima, Kenichi, Edenbrandt, Lars, Mizokami, Atsushi

“…Bone scintigraphy is one of the first‐line imaging modalities for the screening and follow up of bone metastasis in patients with prostate cancer. The amount…”
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Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy by Zhang, Zhe, Qin, Siyuan, Chen, Yan, Zhou, Li, Yang, Mei, Tang, Yongquan, Zuo, Jing, Zhang, Jian, Mizokami, Atsushi, Nice, Edouard C, Chen, Hai‐Ning, Huang, Canhua, Wei, Xiawei

“…Entering a drug‐tolerant persister (DTP) state of cancer cells is a transient self‐adaptive mechanism by which a residual cell subpopulation accelerates tumor…”
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Investigating the mechanism underlying urinary continence using dynamic MRI after Retzius-sparing robot-assisted radical prostatectomy by Kadono, Yoshifumi, Nohara, Takahiro, Kawaguchi, Shohei, Kadomoto, Suguru, Iwamoto, Hiroaki, Iijima, Masashi, Shigehara, Kazuyoshi, Izumi, Kouji, Yoshida, Kotaro, Gabata, Toshifumi, Mizokami, Atsushi

“…Retzius-sparing robot-assisted radical prostatectomy (RS-RARP) exhibits better postoperative urinary continence than conventional RARP (C-RARP) via the…”
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Editorial Comment to Omitting routine cystography after RARP: Analysis of complications and readmission rates in suprapubic and transurethral drained patients by Iwamoto, Hiroaki, Izumi, Kouji, Mizokami, Atsushi

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Reconsideration of progression to CRPC during androgen deprivation therapy by Mizokami, Atsushi, Namiki, Mikio

“…•Residual androgens from adrenal DHEA in PCa develop androgen-naïve PCa into CRPC.•Total androgen deprivation is effective for CRPC even after docetaxel…”
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Relationship between Testosterone and Sarcopenia in Older-Adult Men: A Narrative Review by Shigehara, Kazuyoshi, Kato, Yuki, Izumi, Kouji, Mizokami, Atsushi

“…Age-related decline in testosterone is known to be associated with various clinical symptoms among older men and it is possible that the accompanying decline…”
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CCL2 induces resistance to the antiproliferative effect of cabazitaxel in prostate cancer cells by Natsagdorj, Ariunbold, Izumi, Kouji, Hiratsuka, Kaoru, Machioka, Kazuaki, Iwamoto, Hiroaki, Naito, Renato, Makino, Tomoyuki, Kadomoto, Suguru, Shigehara, Kazuyoshi, Kadono, Yoshifumi, Lin, Wen‐Jye, Maolake, Aerken, Mizokami, Atsushi

“…Understanding the mechanism of chemoresistance and disease progression in patients with prostate cancer is important for developing novel treatment strategies…”
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Single-Cell Transcriptomics Analysis Identifies Nuclear Protein 1 as a Regulator of Docetaxel Resistance in Prostate Cancer Cells by Schnepp, Patricia M, Shelley, Greg, Dai, Jinlu, Wakim, Nicole, Jiang, Hui, Mizokami, Atsushi, Keller, Evan T

“…The majority of patients with prostate cancer treated with docetaxel develop resistance to it. To better understand the mechanism behind the acquisition of…”
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Three‐dimensional reconstruction of testis cords/seminiferous tubules by Nakata, Hiroki, Iseki, Shoichi, Mizokami, Atsushi

“…Background Due to the development of novel equipment for the acquisition of two‐dimensional serial images and software capable of displaying three‐dimensional…”
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Up-Regulation of LAT1 during Antiandrogen Therapy Contributes to Progression in Prostate Cancer Cells by Xu, Minhui, Sakamoto, Shinichi, Matsushima, Jun, Kimura, Toru, Ueda, Takeshi, Mizokami, Atsushi, Kanai, Yoshikatsu, Ichikawa, Tomohiko

“…Purpose Cancer cells require massive amounts of amino acids for survival. LAT1 (L-type amino acid transporter 1) transports essential amino acids, including…”
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Suppressive Role of Androgen/Androgen Receptor Signaling via Chemokines on Prostate Cancer Cells by Izumi, Kouji, Mizokami, Atsushi

“…Androgen/androgen receptor (AR) signaling is a significant driver of prostate cancer progression, therefore androgen-deprivation therapy (ADT) is often used as…”
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Three-dimensional morphological analysis of spermatogenesis in aged mouse testes by Nakano, Taito, Nakata, Hiroki, Kadomoto, Suguru, Iwamoto, Hiroaki, Yaegashi, Hiroshi, Iijima, Masashi, Kawaguchi, Shohei, Nohara, Takahiro, Shigehara, Kazuyoshi, Izumi, Kouji, Kadono, Yoshifumi, Mizokami, Atsushi

“…Spermatogenesis, which is a continuous process from undifferentiated spermatogonia to spermatozoa in the seminiferous tubules, declines with age. To…”
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Tumor necrosis factor‐α induces prostate cancer cell migration in lymphatic metastasis through CCR7 upregulation by Maolake, Aerken, Izumi, Kouji, Natsagdorj, Ariunbold, Iwamoto, Hiroaki, Kadomoto, Suguru, Makino, Tomoyuki, Naito, Renato, Shigehara, Kazuyoshi, Kadono, Yoshifumi, Hiratsuka, Kaoru, Wufuer, Guzailinuer, Nastiuk, Kent L., Mizokami, Atsushi

“…Understanding the mechanism of lymph node metastasis, a poor prognostic sign for prostate cancer, and the further dissemination of the disease is important to…”
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Anti-proliferative and anti-migratory properties of coffee diterpenes kahweol acetate and cafestol in human renal cancer cells by Makino, Tomoyuki, Izumi, Kouji, Hiratsuka, Kaoru, Kano, Hiroshi, Shimada, Takashi, Nakano, Taito, Kadomoto, Suguru, Naito, Renato, Iwamoto, Hiroaki, Yaegashi, Hiroshi, Shigehara, Kazuyoshi, Kadono, Yoshifumi, Nakata, Hiroki, Saito, Yohei, Nakagawa-Goto, Kyoko, Sakai, Norihiko, Iwata, Yasunori, Wada, Takashi, Mizokami, Atsushi

“…Despite improvements in systemic therapy options for renal cancer, it remains one of the most drug-resistant malignancies. Interestingly, reports have shown…”
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Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2‐induced STAT3 activation by Izumi, Kouji, Fang, Lei‐Ya, Mizokami, Atsushi, Namiki, Mikio, Li, Lei, Lin, Wen‐Jye, Chang, Chawnshang

“…Increased CCL2 expression in prostate cancer (PCa) cells enhanced metastasis via macrophage recruitment. However, its linkage to androgen receptor…”
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