Search Results - "Miyazaki, Shojiro"

A Case of Bilateral HER2-Positive Invasive Ductal Carcinoma with Complete Response on One Side with Trastuzumab Deruxtecan by Miyazaki, Shojiro, Iwasaki, Kei, Narita, Toru, Yoneda, Godai, Takei, Hiroyuki, Jibiki, Norie

“…A 52-year-old female with stage Ⅳ, bilateral, HER2-positive, breast cancer as well as bilateral axillary lymph node(LN) metastasis and bilateral pulmonary…”
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Novel CC chemokine receptor 4 antagonist RS-1154 inhibits ovalbumin-induced ear swelling in mice by Nakagami, Yasuhiro, Kawashima, Kayo, Yonekubo, Kazuki, Etori, Maki, Jojima, Takaaki, Miyazaki, Shojiro, Sawamura, Ryoko, Hirahara, Kazuki, Nara, Futoshi, Yamashita, Makoto

“…CC chemokine ligand 17 (CCL17/thymus and activation-regulated chemokine: TARC) and CCL22 (macrophage-derived chemokine: MDC) selectively bind to CC chemokine…”
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Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors by Nakamura, Yuji, Sugita, Chie, Meguro, Masaki, Miyazaki, Shojiro, Tamaki, Kazuhiko, Takahashi, Mizuki, Nagai, Yoko, Nagayama, Takahiro, Kato, Mikio, Suemune, Hiroshi, Nishi, Takahide

“…Introduction of the 2,2-dimethyl-4-phenylpiperazin-5-one scaffold into the P3–P1 portion of the…”
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Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor by Nakamura, Yuji, Fujimoto, Teppei, Ogawa, Yasuyuki, Sugita, Chie, Miyazaki, Shojiro, Tamaki, Kazuhiko, Takahashi, Mizuki, Matsui, Yumi, Nagayama, Takahiro, Manabe, Kenichi, Mizuno, Makoto, Masubuchi, Noriko, Chiba, Katsuyoshi, Nishi, Takahide

“…A novel orally bioavailable renin inhibitor, DS-8108b (5), showing potent renin inhibitory activity and excellent in vivo efficacy is described. We report…”
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Efficient Synthesis of 5-Amino-6-dialkylamino-4-hydroxypentanamide Derivatives for Renin Inhibitors by Nakamura, Yuji, Suzuki, Chie, Fujimoto, Teppei, Miyazaki, Shojiro, Tamaki, Kazuhiko, Nishi, Takahide, Suemune, Hiroshi

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In Vitro and In Vivo Pharmacological Profiles of DS‐1211, a Novel Potent, Selective, and Orally Bioavailable Tissue‐Nonspecific Alkaline Phosphatase Inhibitor by Soma, Kaori, Izumi, Masanori, Yamamoto, Yuko, Miyazaki, Shojiro, Watanabe, Kengo

“…ABSTRACT Inhibition of tissue‐nonspecific alkaline phosphatase (TNAP) may prevent ectopic soft tissue calcification by increasing endogenous pyrophosphate…”
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Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist by Nishi, Takahide, Miyazaki, Shojiro, Takemoto, Toshiyasu, Suzuki, Keisuke, Iio, Yukiko, Nakajima, Katsuyoshi, Ohnuki, Takashi, Kawase, Yumi, Nara, Futoshi, Inaba, Shinichi, Izumi, Takashi, Yuita, Hiroshi, Oshima, Keiko, Doi, Hiromi, Inoue, Ryotaku, Tomisato, Wataru, Kagari, Takashi, Shimozato, Takaichi

“…CS-0777 (3) is phosphorylated in vivo, and the phosphate of CS-0777 (CS-0777-P) (4) acts as a selective S1P receptor-1 (S1P1) modulator. We report herein the…”
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The total synthesis and absolute structure of antifungal antibiotics(-)-PF1163A and B by Tatsuta, K, Takano, S, Ikeda, Y, Nakano, S, Miyazaki, S

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Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: Discovery of DS-8108b, an orally active renin inhibitor by Nakamura, Yuji, Fujimoto, Teppei, Ogawa, Yasuyuki, Namiki, Hidenori, Suzuki, Sayaka, Asano, Masayoshi, Sugita, Chie, Mochizuki, Akiyoshi, Miyazaki, Shojiro, Tamaki, Kazuhiko, Nagai, Yoko, Inoue, Shin-ichi, Nagayama, Takahiro, Kato, Mikio, Chiba, Katsuyoshi, Takasuna, Kiyoshi, Nishi, Takahide

“…With the aim to address an undesired cardiac issue observed with our related compound in the recently disclosed novel series of renin inhibitors, further…”
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Discovery of CS-0777: A Potent, Selective, and Orally Active S1P 1 Agonist by Nishi, Takahide, Miyazaki, Shojiro, Takemoto, Toshiyasu, Suzuki, Keisuke, Iio, Yukiko, Nakajima, Katsuyoshi, Ohnuki, Takashi, Kawase, Yumi, Nara, Futoshi, Inaba, Shinichi, Izumi, Takashi, Yuita, Hiroshi, Oshima, Keiko, Doi, Hiromi, Inoue, Ryotaku, Tomisato, Wataru, Kagari, Takashi, Shimozato, Takaichi

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Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors by Mori, Yutaka, Ogawa, Yasuyuki, Mochizuki, Akiyoshi, Nakamura, Yuji, Fujimoto, Teppei, Sugita, Chie, Miyazaki, Shojiro, Tamaki, Kazuhiko, Nagayama, Takahiro, Nagai, Yoko, Inoue, Shin-ichi, Chiba, Katsuyoshi, Nishi, Takahide

“…We report synthesis and optimization of a series of (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as renin inhibitors…”
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Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3- c arboxamides as orally active renin inhibitors by Mori, Yutaka, Ogawa, Yasuyuki, Mochizuki, Akiyoshi, Nakamura, Yuji, Fujimoto, Teppei, Sugita, Chie, Miyazaki, Shojiro, Tamaki, Kazuhiko, Nagayama, Takahiro, Nagai, Yoko, Inoue, Shin-ichi, Chiba, Katsuyoshi, Nishi, Takahide

“…We report synthesis and optimization of a series of (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3- c arboxamides as renin inhibitors…”
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Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors by Mori, Yutaka, Ogawa, Yasuyuki, Mochizuki, Akiyoshi, Nakamura, Yuji, Sugita, Chie, Miyazaki, Shojiro, Tamaki, Kazuhiko, Matsui, Yumi, Takahashi, Mizuki, Nagayama, Takahiro, Nagai, Yoko, Inoue, Shin-ichi, Nishi, Takahide

“…Utilizing X-ray crystal structure analysis, (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides were designed and…”
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Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]pip e ridine-3-carboxamides as potent renin inhibitors by Mori, Yutaka, Ogawa, Yasuyuki, Mochizuki, Akiyoshi, Nakamura, Yuji, Sugita, Chie, Miyazaki, Shojiro, Tamaki, Kazuhiko, Matsui, Yumi, Takahashi, Mizuki, Nagayama, Takahiro, Nagai, Yoko, Inoue, Shin-ichi, Nishi, Takahide

“…Utilizing X-ray crystal structure analysis, (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]pip e ridine-3-carboxamides were designed and…”
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Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhex a namides to reduce a cardiac safety issue: Discovery of DS-8108b, an orally active renin inhibitor by Nakamura, Yuji, Fujimoto, Teppei, Ogawa, Yasuyuki, Namiki, Hidenori, Suzuki, Sayaka, Asano, Masayoshi, Sugita, Chie, Mochizuki, Akiyoshi, Miyazaki, Shojiro, Tamaki, Kazuhiko, Nagai, Yoko, Inoue, Shin-ichi, Nagayama, Takahiro, Kato, Mikio, Chiba, Katsuyoshi, Takasuna, Kiyoshi, Nishi, Takahide

“…With the aim to address an undesired cardiac issue observed with our related compound in the recently disclosed novel series of renin inhibitors, further…”
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Asymmetric synthesis of α,α-disubstituted α-amino alcohol derivatives by Nakamura, Tsuyoshi, Tsuji, Takashi, Iio, Yukiko, Miyazaki, Shojiro, Takemoto, Toshiyasu, Nishi, Takahide

“…We herein report an asymmetric synthesis of α,α-disubstituted α-amino alcohol derivatives 3, key intermediates of a novel immunomodulator, using enzymatic…”
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Liver regeneration and restoration of liver function after partial hepatectomy: the relation of fibrosis of the liver parenchyma by Miyazaki, S, Takasaki, K, Yamamoto, M, Tsugita, M, Otsubo, T

“…Patients who survive partial hepatectomy sometimes have unsatisfactory liver regeneration and restoration of liver function. Although the extent of resection…”
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Polar cycloaddition of 9-thiaphenanthrenium salt with 1,3-dienes by Shimizu, Hiroshi, Miyazaki, Shojiro, Kataoka, Tadashi

“…Treatment of 9-thiaphenanthrenium salt 1 with conjugated dienes underwent regio- and stereospecific [2++4]-type polar cycloaddition to afford the corresponding…”
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