Search Results - "Miyaura, Chisato"

Hypergravity and microgravity exhibited reversal effects on the bone and muscle mass in mice by Tominari, Tsukasa, Ichimaru, Ryota, Taniguchi, Keita, Yumoto, Akane, Shirakawa, Masaki, Matsumoto, Chiho, Watanabe, Kenta, Hirata, Michiko, Itoh, Yoshifumi, Shiba, Dai, Miyaura, Chisato, Inada, Masaki

“…Spaceflight is known to induce severe systemic bone loss and muscle atrophy of astronauts due to the circumstances of microgravity. We examined the influence…”
Get full text

Gram-positive bacteria cell wall-derived lipoteichoic acid induces inflammatory alveolar bone loss through prostaglandin E production in osteoblasts by Tominari, Tsukasa, Sanada, Ayumi, Ichimaru, Ryota, Matsumoto, Chiho, Hirata, Michiko, Itoh, Yoshifumi, Numabe, Yukihiro, Miyaura, Chisato, Inada, Masaki

“…Periodontitis is an inflammatory disease associated with severe alveolar bone loss and is dominantly induced by lipopolysaccharide from Gram-negative bacteria;…”
Get full text

Polymethoxy Flavonoids, Nobiletin and Tangeretin, Prevent Lipopolysaccharide-Induced Inflammatory Bone Loss in an Experimental Model for Periodontitis by Tominari, Tsukasa, Hirata, Michiko, Matsumoto, Chiho, Inada, Masaki, Miyaura, Chisato

“…Nobiletin, a polymethoxy flavonoid (PMF), inhibits systemic bone resorption and maintains bone mass in estrogen-deficient ovariectomized mice. This study…”
Get full text

Endosomal TLR3 signaling in stromal osteoblasts induces prostaglandin E2–mediated inflammatory periodontal bone resorption by Tominari, Tsukasa, Akita, Miyuki, Matsumoto, Chiho, Hirata, Michiko, Yoshinouchi, Shosei, Tanaka, Yuki, Karouji, Kento, Itoh, Yoshifumi, Maruyama, Takayuki, Miyaura, Chisato, Numabe, Yukihiro, Inada, Masaki

“…Toll-like receptors (TLRs) are pattern recognition receptors that play a critical role in innate immune diseases. TLR3, which is localized in the endosomal…”
Get full text

Low Molecular-Weight Curdlan, (1→3)-β-Glucan Suppresses TLR2-Induced RANKL-Dependent Bone Resorption by Aizawa, Maki, Watanabe, Kenta, Tominari, Tsukasa, Matsumoto, Chiho, Hirata, Michiko, Grundler, Florian M. W., Inada, Masaki, Miyaura, Chisato

“…Fungal β-glucan is a potent immunological stimulator, and that it activates both the innate immune system and adaptive immunity. Curdlan is (1→3)-β-glucan, a…”
Get full text

Lutein Enhances Bone Mass by Stimulating Bone Formation and Suppressing Bone Resorption in Growing Mice by Takeda, Hiroshi, Tominari, Tsukasa, Hirata, Michiko, Watanabe, Kenta, Matsumoto, Chiho, Grundler, Florian M. W., Inada, Masaki, Miyaura, Chisato

“…Lutein is a member of the xanthophyll family of carotenoids, which are known to prevent hypoxia-induced cell damage in the eye by removing free radicals…”
Get full text

Establishment of a Triple Quadrupole HPLC-MS Quantitation Method for Dystrophin Protein in Mouse and Human Skeletal Muscle by Tominari, Tsukasa, Takatoya, Masaru, Matsubara, Toshiya, Matsunobe, Michio, Arai, Daichi, Matsumoto, Chiho, Hirata, Michiko, Yoshinouchi, Shosei, Miyaura, Chisato, Itoh, Yoshifumi, Komaki, Hirofumi, Takeda, Shin'ichi, Aoki, Yoshitsugu, Inada, Masaki

“…Duchenne muscular dystrophy (DMD) is the most common type of neuromuscular disease caused by mutations in the gene encoding dystrophin protein. To quantitively…”
Get full text

Molecular evidence of IGFBP-3 dependent and independent VD3 action and its nonlinear response on IGFBP-3 induction in prostate cancer cells by Igarashi, Ko, Yui, Yoshihiro, Watanabe, Kenta, Kumai, Jun, Nishizawa, Yasuko, Miyaura, Chisato, Inada, Masaki, Sasagawa, Satoru

“…Clinical trials have been conducted to clarify the beneficial effects of VD3 (1α,25-dihydroxy vitamin D3, also known as calcitriol) treatment in prostate…”
Get full text

The Combination of Soy Isoflavones and Resveratrol Preserve Bone Mineral Density in Hindlimb-Unloaded Mice by Tousen, Yuko, Ichimaru, Ryota, Kondo, Takashi, Inada, Masaki, Miyaura, Chisato, Ishimi, Yoshiko

“…It is well known that physical inactivity during space flight or prolonged bed rest causes rapid bone loss. Soy isoflavones (ISOs) and resveratrol (RES) have…”
Get full text

The MET/Vascular Endothelial Growth Factor Receptor (VEGFR)-targeted Tyrosine Kinase Inhibitor Also Attenuates FMS-dependent Osteoclast Differentiation and Bone Destruction Induced by Prostate Cancer by Watanabe, Kenta, Hirata, Michiko, Tominari, Tsukasa, Matsumoto, Chiho, Fujita, Hidenori, Yonekura, Kazuhiko, Murphy, Gillian, Nagase, Hideaki, Miyaura, Chisato, Inada, Masaki

“…The tyrosine kinase inhibitor TAS-115 that blocks VEGF receptor and hepatocyte growth factor receptor MET signaling exhibits antitumor properties in xenografts…”
Get full text

The Optimal Duration of PTH(1–34) Infusion Is One Hour per Day to Increase Bone Mass in Rats by Shimizu, Masaru, Noda, Hiroshi, Joyashiki, Eri, Nakagawa, Chie, Asanuma, Kentaro, Hayasaka, Akira, Kato, Motohiro, Nanami, Masahiko, Inada, Masaki, Miyaura, Chisato, Tamura, Tatsuya

“…Parathyroid hormone (PTH) is a potential medicine for osteoporosis, and subcutaneous (s.c.) PTH treatment enhances bone mass; however, continuous infusion of…”
Get full text

Critical Roles for Collagenase-3 (Mmp13) in Development of Growth Plate Cartilage and in Endochondral Ossification by Inada, Masaki, Wang, Yingmin, Byrne, Michael H., Rahman, Mahboob U., Miyaura, Chisato, López-Otín, Carlos, Krane, Stephen M., Rosenberg, Leon E.

“…Collagenase-3 (MMP13), a member of the matrix metalloproteinase (MMP) family of neutral endopeptidases, is expressed in the skeleton during embryonic…”
Get full text

Beta-Cryptoxanthin Inhibits Lipopolysaccharide-Induced Osteoclast Differentiation and Bone Resorption via the Suppression of Inhibitor of NF-κB Kinase Activity by Hirata, Narumi, Ichimaru, Ryota, Tominari, Tsukasa, Matsumoto, Chiho, Watanabe, Kenta, Taniguchi, Keita, Hirata, Michiko, Ma, Sihui, Suzuki, Katsuhiko, Grundler, Florian M W, Miyaura, Chisato, Inada, Masaki

“…Beta-cryptoxanthin (β-cry) is a typical carotenoid found abundantly in fruit and vegetables such as the Japanese mandarin orange, persimmon, papaya, paprika,…”
Get full text

Toll-like receptor 2 heterodimers, TLR2/6 and TLR2/1 induce prostaglandin E production by osteoblasts, osteoclast formation and inflammatory periodontitis by Matsumoto, Chiho, Oda, Toshio, Yokoyama, Satoshi, Tominari, Tsukasa, Hirata, Michiko, Miyaura, Chisato, Inada, Masaki

“…► We examine the role of TLR2 heterodimer signaling in bone metabolism. ► Both TLR2/6 ligand and TLR2/1 ligand markedly induce osteoclast formation in vitro. ►…”
Get full text

Indoxyl sulfate, a uremic toxin in chronic kidney disease, suppresses both bone formation and bone resorption by Watanabe, Kenta, Tominari, Tsukasa, Hirata, Michiko, Matsumoto, Chiho, Hirata, Junya, Murphy, Gillian, Nagase, Hideaki, Miyaura, Chisato, Inada, Masaki

“…Abnormalities of bone turnover are commonly observed in patients with chronic kidney disease (CKD), and the low‐turnover bone disease is considered to be…”
Get full text

Roles of Toll-like Receptor Signaling in Inflammatory Bone Resorption by Tominari, Tsukasa, Matsumoto, Chiho, Tanaka, Yuki, Shimizu, Kensuke, Takatoya, Masaru, Sugasaki, Moe, Karouji, Kento, Kasuga, Urara, Miyaura, Chisato, Miyata, Shinji, Itoh, Yoshifumi, Hirata, Michiko, Inada, Masaki

“…Toll-like receptors (TLRs) are pattern recognition receptors expressed in immune cells, including neutrophils, macrophages, and dendritic cells…”
Get full text

A mouse model of lung cancer induced via intranasal injection for anticancer drug screening and evaluation of pathology by Tanaka, Ryo, Yoshinouchi, Shosei, Karouji, Kento, Tanaka, Yuki, Tominari, Tsukasa, Hirata, Michiko, Matsumoto, Chiho, Itoh, Yoshifumi, Miyaura, Chisato, Inada, Masaki

“…The pathologies and lethality of lung cancers are associated with smoking, lifestyle, and genomic factors. Several experimental mouse models of lung cancer,…”
Get full text

Nobiletin, a Polymethoxy Flavonoid, Suppresses Bone Resorption by Inhibiting NFκB-Dependent Prostaglandin E Synthesis in Osteoblasts and Prevents Bone Loss Due to Estrogen Deficiency by Harada, Suguru, Tominari, Tsukasa, Matsumoto, Chiho, Hirata, Michiko, Takita, Morichika, Inada, Masaki, Miyaura, Chisato

“…Nobiletin, a polymethoxy flavonoid, prevents cancer and inflammation, but the roles of nobiletin in bone are unclear. We examined the effects of nobiletin on…”
Get full text

Effects of 4'-Demethylnobiletin and 4'-Demethyltangeretin on Osteoclast Differentiation In Vitro and in a Mouse Model of Estrogen-Deficient Bone Resorption by Hirata, Michiko, Tominari, Tsukasa, Ichimaru, Ryota, Takiguchi, Naruhiko, Tanaka, Yuki, Takatoya, Masaru, Arai, Daichi, Yoshinouchi, Shosei, Miyaura, Chisato, Matsumoto, Chiho, Ma, Sihui, Suzuki, Katsuhiko, Grundler, Florian M W, Inada, Masaki

“…Citrus nobiletin (NOB) and tangeretin (TAN) show protective effects against disease-related bone destruction. We achieved demethylation of NOB and TAN into…”
Get full text

Lutein, a carotenoid, suppresses osteoclastic bone resorption and stimulates bone formation in cultures by Tominari, Tsukasa, Matsumoto, Chiho, Watanabe, Kenta, Hirata, Michiko, Grundler, Florian M.W., Inada, Masaki, Miyaura, Chisato

“…Lutein, a member of the xanthophyll family of carotenoids, suppressed IL-1-induced osteoclast differentiation and bone resorption. The survival of mature…”
Get full text