Search Results - "Miyatake, Hideki"

Total Synthesis of the Protected Aglycon of Fidaxomicin (Tiacumicin B, Lipiarmycin A3) by Miyatake-Ondozabal, Hideki, Kaufmann, Elias, Gademann, Karl

“…Fidaxomicin, also known as tiacumicin B or lipiarmycin A3, is a novel macrocyclic antibiotic that is used in hospitals for the treatment of Clostridium…”
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Total Synthesis and Biological Evaluation of the Glycosylated Macrocyclic Antibiotic Mangrolide A by Hattori, Hiromu, Roesslein, Joel, Caspers, Patrick, Zerbe, Katja, Miyatake‐Ondozabal, Hideki, Ritz, Daniel, Rueedi, Georg, Gademann, Karl

“…The macrocyclic antibiotic mangrolide A has been described to exhibit potent activity against a number of clinically important Gram‐negative pathogens…”
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Total Synthesis of Tiacumicin A. Total Synthesis, Relay Synthesis, and Degradation Studies of Fidaxomicin (Tiacumicin B, Lipiarmycin A3) by Hattori, Hiromu, Kaufmann, Elias, Miyatake-Ondozabal, Hideki, Berg, Regina, Gademann, Karl

“…The commercial macrolide antibiotic fidaxomicin was synthesized in a highly convergent manner. Salient features of this synthesis include a β-selective…”
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Discovery of BAY-405: An Azaindole-Based MAP4K1 Inhibitor for the Enhancement of T‑Cell Immunity against Cancer by Mowat, Jeffrey, Carretero, Rafael, Leder, Gabriele, Aiguabella Font, Nuria, Neuhaus, Roland, Berndt, Sandra, Günther, Judith, Friberg, Anders, Schäfer, Martina, Briem, Hans, Raschke, Marian, Miyatake Ondozabal, Hideki, Buchmann, Bernd, Boemer, Ulf, Kreft, Bertolt, Hartung, Ingo V., Offringa, Rienk

“…Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) is a serine/threonine kinase that acts as an immune checkpoint downstream of T-cell receptor…”
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Discovery of BAY-390, a Selective CNS Penetrant Chemical Probe as Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonist by Mesch, Stefanie, Walter, Daryl, Laux-Biehlmann, Alexis, Basting, Daniel, Flanagan, Stuart, Miyatake Ondozabal, Hideki, Bäurle, Stefan, Pearson, Christopher, Jenkins, James, Elves, Philip, Hess, Stephen, Coelho, Anne-Marie, Rotgeri, Andrea, Bothe, Ulrich, Nawaz, Schanila, Zollner, Thomas M., Steinmeyer, Andreas

“…Transient receptor potential ankyrin 1 (TRPA1) is a voltage-dependent, ligand-gated ion channel, and activation thereof is linked to a variety of painful…”
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Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virus infection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I by Miyazaki, Masanori, Kanto, Tatsuya, Inoue, Michiyo, Itose, Ichiyo, Miyatake, Hideki, Sakakibara, Mitsuru, Yakushijin, Takayuki, Kakita, Naruyasu, Hiramatsu, Naoki, Takehara, Tetsuo, Kasahara, Akinori, Hayashi, Norio

“…Dendritic cells utilize various sets of Toll-like receptors (TLR) or cytosolic sensors to detect pathogens and evoke immune responses. In patients with…”
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A novel biomimetic synthesis of ( S)-(−)-zearalenone: via macrocyclization and transannular aromatization by Miyatake-Ondozabal, Hideki, Barrett, Anthony G.M.

“…On heating, a hydroxy-keto-dioxinone underwent retro-Diels–Alder fragmentation and the resultant α,γ-diketo-ketene was efficiently trapped intramolecularly by…”
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Total Synthesis of TAK-Kinase Inhibitor LL-Z1640-2 via Consecutive Macrocyclization and Transannular Aromatization by Miyatake-Ondozabal, Hideki, Barrett, Anthony G. M

“…The biomimetic total synthesis of LL-Z1640-2 (3) is reported without the use of phenol protection. The aromatic unit was constructed via the transannular…”
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Total Synthesis and Biological Evaluation of the Glycosylated Macrocyclic Antibiotic Mangrolide A by Hattori, Hiromu, Roesslein, Joel, Caspers, Patrick, Zerbe, Katja, Miyatake‐Ondozabal, Hideki, Ritz, Daniel, Rueedi, Georg, Gademann, Karl

“…The macrocyclic antibiotic mangrolide A has been described to exhibit potent activity against a number of clinically important Gram‐negative pathogens…”
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Reduced Numbers and Impaired Ability of Myeloid and Plasmacytoid Dendritic Cells to Polarize T Helper Cells in Chronic Hepatitis C Virus Infection by Kanto, Tatsuya, Inoue, Michiyo, Miyatake, Hideki, Sato, Aki, Sakakibara, Mitsuru, Yakushijin, Takayuki, Oki, Chika, Itose, Ichiyo, Hiramatsu, Naoki, Takehara, Tetsuo, Kasahara, Akinori, Hayashi, Norio

“…Hepatitis C virus (HCV) infection induces a wide range of chronic liver injuries. The mechanism by which HCV evades the immune surveillance system remains…”
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Comprehensive immunological analyses of colorectal cancer patients in the phase I/II study of quickly matured dendritic cell vaccine pulsed with carcinoembryonic antigen peptide by Sakakibara, Mitsuru, Kanto, Tatsuya, Hayakawa, Michiyo, Kuroda, Shoko, Miyatake, Hideki, Itose, Ichiyo, Miyazaki, Masanori, Kakita, Naruyasu, Higashitani, Koyo, Matsubara, Tokuhiro, Hiramatsu, Naoki, Kasahara, Akinori, Takehara, Tetsuo, Hayashi, Norio

“…Dendritic cell (DC) vaccine has been used to treat patients with advanced colorectal cancer (CRC). The results of vaccine-induced clinical responses have not…”
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Totalsynthese des geschützten Aglycons von Fidaxomicin (Tiacumicin B, Lipiarmycin A3) by Miyatake-Ondozabal, Hideki, Kaufmann, Elias, Gademann, Karl

“…Fidaxomicin, auch Tiacumicin B oder Lipiarmycin A3 genannt, ist ein neuartiges makrocyclisches Antibiotikum, das klinisch gegen…”
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Total Synthesis of the Glycosylated Macrolide Antibiotic Fidaxomicin by Kaufmann, Elias, Hattori, Hiromu, Miyatake-Ondozabal, Hideki, Gademann, Karl

“…The first enantioselective total synthesis of fidaxomicin, also known as tiacumicin B or lipiarmycin A3, is reported. This novel glycosylated macrolide…”
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Enhanced ability of peripheral invariant natural killer T cells to produce IL-13 in chronic hepatitis C virus infection by Inoue, Michiyo, Kanto, Tatsuya, Miyatake, Hideki, Itose, Ichiyo, Miyazaki, Masanori, Yakushijin, Takayuki, Sakakibara, Mitsuru, Kuzushita, Noriyoshi, Hiramatsu, Naoki, Takehara, Tetsuo, Kasahara, Akinori, Hayashi, Norio

“…Human invariant natural killer T (iNKT) cells express a TCR Vα24-JαQ paired with Vβ11 and are activated by a surrogate ligand, α-galactosylceramide (αGalCer)…”
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Investigating Biogenetic Hypotheses of the Securinega Alkaloids: Enantioselective Total Syntheses of Secu’amamine E/ent-Virosine A and Bubbialine by Wehlauch, Robin, Grendelmeier, Simone M, Miyatake-Ondozabal, Hideki, Sandtorv, Alexander H, Scherer, Manuel, Gademann, Karl

“…The synthesis of the Securinega alkaloid secu’amamine E (ent-virosine A) has been accomplished for the first time in 12 steps and 8.5% overall yield. In…”
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Enantioselective total synthesis of virosaine A and bubbialidine by Miyatake-Ondozabal, Hideki, Bannwart, Linda M, Gademann, Karl

“…The first enantioselective total syntheses of virosaine A and bubbialidine are described. Key transformations include the formation of a tetracyclic…”
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Impaired function of dendritic cells circulating in patients infected with hepatitis C virus who have persistently normal alanine aminotransferase levels by Kanto, Tatsuya, Inoue, Michiyo, Miyazaki, Masanori, Itose, Ichiyo, Miyatake, Hideki, Sakakibara, Mitsuru, Yakushijin, Takayuki, Kaimori, Aki, Oki, Chika, Hiramatsu, Naoki, Kasahara, Akinori, Hayashi, Norio

“…Hepatitis C virus (HCV) induces chronic liver disease in hosts which can eventually progresses to liver cirrhosis and hepatocellular carcinoma. However,…”
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Involvement of dendritic cell frequency and function in virological relapse in pegylated interferon-α and ribavirin therapy for chronic hepatitis C patients by Itose, Ichiyo, Kanto, Tatsuya, Inoue, Michiyo, Miyazaki, Masanori, Miyatake, Hideki, Sakakibara, Mitsuru, Yakushijin, Takayuki, Oze, Tsugiko, Hiramatsu, Naoki, Takehara, Tetsuo, Kasahara, Akinori, Katayama, Kazuhiro, Kato, Michio, Hayashi, Norio

“…A combination of pegylated interferon α (PEG‐IFNα) and ribavirin has been used widely. Enhancement of immune response against hepatitis C virus (HCV) is known…”
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Synthesis of (−)-(S,S)-clemastine by Invertive N → C Aryl Migration in a Lithiated Carbamate by Fournier, Anne M, Brown, Robert A, Farnaby, William, Miyatake-Ondozabal, Hideki, Clayden, Jonathan

“…The first enantioselective synthesis of the antihistamine agent clemastine, as its (S,S)-stereoisomer, has been achieved by ether formation between a…”
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Pseudotype hepatitis C virus enters immature myeloid dendritic cells through the interaction with lectin by Kaimori, Aki, Kanto, Tatsuya, Kwang Limn, Chang, Komoda, Yasumasa, Oki, Chika, Inoue, Michiyo, Miyatake, Hideki, Itose, Ichiyo, Sakakibara, Mitsuru, Yakushijin, Takayuki, Takehara, Tetsuo, Matsuura, Yoshiharu, Hayashi, Norio

“…Dendritic cells (DC) are the most potent antigen-presenting cells that regulate immune responses. One of the mechanisms for hepatitis C virus (HCV) persistence…”
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