Search Results - "Miyasaka, Tomohiro"

Regulatory mechanisms for the axonal localization of tau protein in neurons by Iwata, Minori, Watanabe, Shoji, Yamane, Ayaka, Miyasaka, Tomohiro, Misonou, Hiroaki

“…Tau is a microtubule (MT)-associated protein that is thought to be localized to the axon. However, its precise localization in developing neurons and…”
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MS785-MS27 Reactive Misfolded/Non-Native Zn-Deficient SOD1 Species Exhibit Cytotoxicity and Adopt Heterozygous Conformations in Motor Neurons by Tokuda, Eiichi, Sakashita, Yume, Tokoro, Naoya, Date, Ayano, Kosuge, Yasuhiro, Miyasaka, Tomohiro

“…Misfolding of superoxide dismutase-1 (SOD1) is a pathological hallmark of amyotrophic lateral sclerosis (ALS) with mutations. The development of antibodies…”
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Identification of Tau protein as a novel marker for maturation and pathological changes of oligodendrocytes by Torii, Tomohiro, Miyamoto, Yuki, Nakata, Rinaho, Higashi, Yuto, Shinmyo, Yohei, Kawasaki, Hiroshi, Miyasaka, Tomohiro, Misonou, Hiroaki

“…Microtubule‐associated protein Tau is primarily expressed in axons of neurons, but also in Olig2‐positive oligodendrocytes in adult rodent and monkey brains…”
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Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer's disease synapse model by Hori, Tetsuya, Eguchi, Kohgaku, Wang, Han-Ying, Miyasaka, Tomohiro, Guillaud, Laurent, Taoufiq, Zacharie, Mahapatra, Satyajit, Yamada, Hiroshi, Takei, Kohji, Takahashi, Tomoyuki

“…Elevation of soluble wild-type (WT) tau occurs in synaptic compartments in Alzheimer's disease. We addressed whether tau elevation affects synaptic…”
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Distribution of endogenous normal tau in the mouse brain by Kubo, Atsuko, Misonou, Hiroaki, Matsuyama, Makoto, Nomori, Akane, Wada‐Kakuda, Satoko, Takashima, Akihiko, Kawata, Mitsuhiro, Murayama, Shigeo, Ihara, Yasuo, Miyasaka, Tomohiro

“…Abtract Tau is a microtubule‐associated protein (MAP) that is localized to the axon. In Alzheimer's disease (AD), the distribution of tau undergoes a…”
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The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection by Omi, Jumpei, Watanabe-Takahashi, Miho, Igai, Katsura, Shimizu, Eiko, Tseng, Ching-Yi, Miyasaka, Tomohiro, Waku, Tsuyoshi, Hama, Shinichiro, Nakanishi, Rieka, Goto, Yuki, Nishino, Yuri, Miyazawa, Atsuo, Natori, Yasuhiro, Yamashita, Makoto, Nishikawa, Kiyotaka

“…The emergence of drug-resistant influenza type A viruses (IAVs) necessitates the development of novel anti-IAV agents. Here, we target the IAV hemagglutinin…”
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Distinct deposition of amyloid-β species in brains with Alzheimer's disease pathology visualized with MALDI imaging mass spectrometry by Kakuda, Nobuto, Miyasaka, Tomohiro, Iwasaki, Noriyuki, Nirasawa, Takashi, Wada-Kakuda, Satoko, Takahashi-Fujigasaki, Junko, Murayama, Shigeo, Ihara, Yasuo, Ikegawa, Masaya

“…Amyloid β (Aβ) deposition in the brain is an early and invariable feature of Alzheimer's disease (AD). The Aβ peptides are composed of about 40 amino acids and…”
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Disulfide bond formation in microtubule-associated tau protein promotes tau accumulation and toxicity in vivo by Saito, Taro, Chiku, Tomoki, Oka, Mikiko, Wada-Kakuda, Satoko, Nobuhara, Mika, Oba, Toshiya, Shinno, Kanako, Abe, Saori, Asada, Akiko, Sumioka, Akio, Takashima, Akihiko, Miyasaka, Tomohiro, Ando, Kanae

“…Abstract Accumulation of microtubule-associated tau protein is thought to cause neuron loss in a group of neurodegenerative diseases called tauopathies. In…”
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Inhibition of microtubule assembly competent tubulin synthesis leads to accumulation of phosphorylated tau in neuronal cell bodies by Fujiwara, Hitomi, Watanabe, Shoji, Iwata, Minori, Ueda, Shouyou, Nobuhara, Mika, Wada-Kakuda, Satoko, Misonou, Hiroaki, Miyasaka, Tomohiro

“…Neurofibrillary tangles, a pathological hallmark of Alzheimer’s disease (AD), are somatodendritic filamentous inclusions composed of hyperphosphorylated tau…”
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Distribution of oxidized DJ-1 in Parkinson’s disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin by Mita, Yuichiro, Kataoka, Yuto, Saito, Yoshiro, Kashi, Takuma, Hayashi, Kojiro, Iwasaki, Asa, Imanishi, Takanori, Miyasaka, Tomohiro, Noguchi, Noriko

“…DJ-1 plays an important role in antioxidant defenses, and a reactive cysteine at position 106 (Cys106) of DJ-1, a critical residue of its biological function,…”
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The Role of the Carboxyl-Terminal Sequence of Tau and MAP2 in the Pathogenesis of Dementia by Xie, Ce, Miyasaka, Tomohiro

“…Dementia includes several diseases characterized by acquired and irreversible brain dysfunctions that interfere with daily life. According to the etiology,…”
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Identification of key amino acids responsible for the distinct aggregation properties of microtubule‐associated protein 2 and tau by Xie, Ce, Soeda, Yoshiyuki, Shinzaki, Yuki, In, Yasuko, Tomoo, Koji, Ihara, Yasuo, Miyasaka, Tomohiro

“…The carboxyl‐terminal sequence of tau composes the framework for its intracellular inclusions that appear in diverse neurodegenerative disorders known as…”
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The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes by Torii, Tomohiro, Miyasaka, Tomohiro, Misonou, Hiroaki

“…Tau is abundantly expressed in neurons, however previous reports and our recent study showed tau also exist in oligodendrocytes. Also the expression levels of…”
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Mass Spectrometry Imaging in Alzheimer's Disease by Ikegawa, Masaya, Kakuda, Nobuto, Miyasaka, Tomohiro, Toyama, Yumiko, Nirasawa, Takashi, Minta, Karolina, Hanrieder, Jörg

“…Amyloid-beta (Aβ) pathology is the precipitating histopathological characteristic of Alzheimer's disease (AD). Although the formation of amyloid plaques in…”
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Ectopic Expression Induces Abnormal Somatodendritic Distribution of Tau in the Mouse Brain by Kubo, Atsuko, Ueda, Shouyou, Yamane, Ayaka, Wada-Kakuda, Satoko, Narita, Mai, Matsuyama, Makoto, Nomori, Akane, Takashima, Akihiko, Kato, Taisuke, Onodera, Osamu, Goto, Motohito, Ito, Mamoru, Tomiyama, Takami, Mori, Hiroshi, Murayama, Shigeo, Ihara, Yasuo, Misonou, Hiroaki, Miyasaka, Tomohiro

“…Tau is a microtubule (MT)-associated protein that is localized to the axon. In Alzheimer's disease, the distribution of tau undergoes a remarkable alteration,…”
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Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis by Kato, Hajime, Sato, Hiroyasu, Okuda, Michiaki, Wu, Jun, Koyama, Shingo, Izumi, Yasuhiko, Waku, Tomonori, Iino, Mitsuyoshi, Aoki, Masashi, Arawaka, Shigeki, Ohta, Yasuyuki, Ishizawa, Kenichi, Kawasaki, Kanan, Urano, Yasuomi, Miyasaka, Tomohiro, Noguchi, Noriko, Kume, Toshiaki, Akaike, Akinori, Sugimoto, Hachiro, Kato, Takeo

“…The present study investigated the therapeutic effects of the curcumin derivative…”
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Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of Tauopathy by Miyasaka, Tomohiro, Shinzaki, Yuki, Yoshimura, Satomi, Yoshina, Sawako, Kage-Nakadai, Eriko, Mitani, Shohei, Ihara, Yasuo

“…Tauopathy is a type of dementia defined by the accumulation of filamentous tau inclusions in neural cells. Most types of dementia in the elderly, including…”
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Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs by Nakamura, Mari, Shiozawa, Seiji, Tsuboi, Daisuke, Amano, Mutsuki, Watanabe, Hirotaka, Maeda, Sumihiro, Kimura, Taeko, Yoshimatsu, Sho, Kisa, Fumihiko, Karch, Celeste M., Miyasaka, Tomohiro, Takashima, Akihiko, Sahara, Naruhiko, Hisanaga, Shin-ichi, Ikeuchi, Takeshi, Kaibuchi, Kozo, Okano, Hideyuki

“…Mutations in the microtubule-associated protein tau (MAPT) gene are known to cause familial frontotemporal dementia (FTD). The R406W tau mutation is a unique…”
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Microtubule destruction induces tau liberation and its subsequent phosphorylation by Miyasaka, Tomohiro, Sato, Sinji, Tatebayashi, Yoshitaka, Takashima, Akihiko

“…Neurofibrillary tangle-bearing neurons, a pathological hallmark of Alzheimer’s disease, are mostly devoid of normal microtubule (MT) structure and instead have…”
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The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives by Yoshimura, Rikuya, Miyasaka, Tomohiro, Funamoto, Satoru, Saito, Takashi, Saido, Takaomi C., Ikegawa, Masaya, Kakuda, Nobuto

“…The morphology of senile plaques depends on the APP knock‐in mice brain fixative. Solid forms of senile plaques were detected in APP knock‐in mice after formic…”
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