Search Results - "Miyamoto, Yasuhisa"

Identification of Acrylamide Adducts Generated during Storage of Canned Milk Coffee by Yoshioka, Toshiaki, Izumi, Yoshihiro, Takahashi, Masatomo, Suzuki, Koji, Miyamoto, Yasuhisa, Nagatomi, Yasushi, Bamba, Takeshi

“…Since coffee is a significant contributor to the consumption of acrylamide, its reduction is required. Acrylamide is produced during the roasting of coffee…”
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Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice by Maruyama, Takaharu, Tanaka, Kenichi, Suzuki, Jun, Miyoshi, Hiroyuki, Harada, Naomoto, Nakamura, Takao, Miyamoto, Yasuhisa, Kanatani, Akio, Tamai, Yoshitaka

“…G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) is a novel G protein-coupled receptor for bile acid. Tissue distribution and cell-type specificity of…”
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Identification of membrane-type receptor for bile acids (M-BAR) by Maruyama, Takaharu, Miyamoto, Yasuhisa, Nakamura, Takao, Tamai, Yoshitaka, Okada, Hiromasa, Sugiyama, Eiji, Nakamura, Tatsuji, Itadani, Hiraku, Tanaka, Kenichi

“…Bile acids play an essential role in the solubilization and absorption of dietary fat and lipid-soluble vitamins. Bile acids also modulate the transcription of…”
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Functional engineering of human iPSC‐derived parasympathetic neurons enhances responsiveness to gastrointestinal hormones by Akagi, Yuka, Takayama, Yuzo, Nihashi, Yuma, Yamashita, Azusa, Yoshida, Risa, Miyamoto, Yasuhisa, Kida, Yasuyuki S.

“…Food‐derived biological signals are transmitted to the brain via peripheral nerves through the paracrine activity of gastrointestinal (GI) hormones. The signal…”
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Synthesis, Structure−Activity Relationships, and Biological Profiles of a Quinazolinone Class of Histamine H3 Receptor Inverse Agonists by Nagase, Tsuyoshi, Mizutani, Takashi, Ishikawa, Shiho, Sekino, Etsuko, Sasaki, Takahide, Fujimura, Takashi, Ito, Sayaka, Mitobe, Yuko, Miyamoto, Yasuhisa, Yoshimoto, Ryo, Tanaka, Takeshi, Ishihara, Akane, Takenaga, Norihiro, Tokita, Shigeru, Fukami, Takehiro, Sato, Nagaaki

“…A new series of quinazolinone derivatives was synthesized and evaluated as nonimidazole H3 receptor inverse agonists…”
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Development of a High-Density Assay for Long-Chain Fatty Acyl-CoA Elongases by Kitazawa, Hidefumi, Miyamoto, Yasuhisa, Shimamura, Ken, Nagumo, Akira, Tokita, Shigeru

“…We established a convenient assay method for measuring elongation of very long chain fatty acids (ELOVLs) using a Unifilter-96 GF/C plate. The Unifilter GF/C…”
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Therapeutic Potential of Histamine H3 Receptor Agonist for the Treatment of Obesity and Diabetes Mellitus by Yoshimoto, Ryo, Miyamoto, Yasuhisa, Shimamura, Ken, Ishihara, Akane, Takahashi, Kazuhiko, Kotani, Hidehito, Chen, Airu S., Chen, Howard Y., MacNeil, Douglas J., Kanatani, Akio, Tokita, Shigeru

“…Histamine H3 receptors (H3Rs) are located on the presynaptic membranes and cell soma of histamine neurons, where they negatively regulate the synthesis and…”
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プロテオーム解析を用いた生物系異物の起源推定法の検討 by 佐藤, 由佳子, 出羽, 智子, 鈴木, 康司, 永富, 康司, 曲渕, 哲朗, 宮本, 靖久

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レトルト食品中で発見された毛様異物の混入時期推定法の開発 by 山下, 梓, 篠原, 雄治, 坂井, 浩晃, 宮本, 靖久, 鈴木, 康司, 永富, 康司

“…レトルト殺菌を受けた人毛DNAは，湯せんや電子レンジ加熱と比較して著しく断片化することから，この断片化をPCRで検出することでレトルト殺菌履歴の判別，すなわち人毛が工程内で混入したか否かを判断できると考えた．ヒトDNA特異的検出プライマーとして，レトルト殺菌判別には増幅産物長約500…”
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Structure Identification of Contaminants in a Beverage Product by Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry by MIYAMOTO, Yasuhisa, WASHIDA, Kazuto, UYAMA, Atsuo, MOCHIZUKI, Naoki

“…The contaminants in a beverage product that had been reported to have a strange taste were identified. By comparative analysis with the normal product using…”
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Synthesis, structure–activity relationships, and biological profiles of a dihydrobenzoxathiin class of histamine H3 receptor inverse agonists by Sasaki, Takahide, Takahashi, Toshiyuki, Nagase, Tsuyoshi, Mizutani, Takashi, Ito, Sayaka, Mitobe, Yuko, Miyamoto, Yasuhisa, Kanesaka, Maki, Yoshimoto, Ryo, Tanaka, Takeshi, Takenaga, Norihiro, Tokita, Shigeru, Sato, Nagaaki

“…A series of novel dihydrobenzoxathiin derivatives was discovered as potent, selective and orally available human histamine H3 receptor inverse agonists. A…”
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Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor by Ito, Sayaka, Yoshimoto, Ryo, Miyamoto, Yasuhisa, Mitobe, Yuko, Nakamura, Takao, Ishihara, Akane, MacNeil, Douglas J, Kanatani, Akio, Tokita, Shigeru

“…Histamine H(3) receptor antagonists are potential therapeutic agents for cognitive dysfunction, epilepsy, hypersomnia and obesity. GT-2331…”
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Synthesis and evaluation of a novel 2-azabicyclo[2.2.2]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors by Sasaki, Takahide, Nagase, Tsuyoshi, Takahashi, Toshiyuki, Nagumo, Akira, Shimamura, Ken, Miyamoto, Yasuhisa, Kitazawa, Hidefumi, Kanesaka, Maki, Yoshimoto, Ryo, Aragane, Katsumi, Tokita, Shigeru, Sato, Nagaaki

“…A series of novel 2-azabicyclo[2.2.2]octane derivatives was synthesized and evaluated as long chain fatty acid elongase 6 (ELOVL6) inhibitors. Screening of our…”
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Identification and Characterization of a Selective Radioligand for ELOVL6 by Shimamura, Ken, Takahashi, Hidekazu, Kitazawa, Hidefumi, Miyamoto, Yasuhisa, Nagumo, Akira, Tang, Cheng, Dean, Dennis, Nagase, Tsuyoshi, Sato, Nagaaki, Tokita, Shigeru

“…ELOVL6, a member of the elongation of very long-chain fatty acids (ELOVL) family, has recently been identified as the rate-limiting enzyme for the elongation…”
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Impaired drinking response in histamine H3 receptor knockout mice following dehydration or angiotensin-II challenge by Yoshimoto, Ryo, Miyamoto, Yasuhisa, Takahashi, Kazuhiko, Kotani, Hidehito, Kanatani, Akio, Tokita, Shigeru

“…Histamine H3 receptors (H3Rs) are presynaptic receptors that negatively regulate the release of histamine. The present study examined the physiological role of…”
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高速液体クロマトグラフ－四重極飛行時間型質量分析計を用いた飲料中乳および卵主要アレルゲン一斉分析法の開発 by 山下, 梓, 宮本, 靖久, 原山, 耕一, 鈴木, 康司

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Simultaneous fluorometric measurement of histamine and tele-methylhistamine levels in rodent brain by high-performance liquid chromatography by Miyamoto, Yasuhisa, Yoshimoto, Ryo, Yumoto, Mariko, Ishihara, Akane, Takahashi, Kazuhiko, Kotani, Hidehito, Kanatani, Akio, Tokita, Shigeru

“…An improved high-performance liquid chromatography (HPLC) method was developed for simultaneous analysis of histamine (HA) and tele-methylhistamine ( tele-MHA)…”
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A highly sensitive determination method for acrylamide in beverages, grains, and confectioneries by supercritical fluid chromatography tandem mass spectrometry by Yoshioka, Toshiaki, Izumi, Yoshihiro, Nagatomi, Yasushi, Miyamoto, Yasuhisa, Suzuki, Koji, Bamba, Takeshi

“…•Highly sensitive SFC/MS/MS determination method for acrylamide is developed.•The sensitivity of SFC/MS/MS is 11-times higher than that of UHPLC/MS/MS.•The…”
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5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a potent inhibitor for mammalian elongase of long-chain fatty acids family 6: examination of its potential utility as a pharmacological tool by Shimamura, Ken, Kitazawa, Hidefumi, Miyamoto, Yasuhisa, Kanesaka, Maki, Nagumo, Akira, Yoshimoto, Ryo, Aragane, Katsumi, Morita, Naomi, Ohe, Tomoyuki, Takahashi, Toshiyuki, Nagase, Tsuyoshi, Sato, Nagaaki, Tokita, Shigeru

“…Long-chain fatty acid elongases reside in the endoplasmic reticulum and are responsible for the rate-limiting step of the elongation of long-chain fatty acids…”
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高速液体クロマトグラフ―四重極飛行時間型質量分析計を用いた飲料中混入物の同定 by 宮本, 靖久, 鷲田, 和人, 宇山, 敦生, 望月, 直樹

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