Search Results - "Miyamoto, Tatsuo"

Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway by Zhang, Ying, Lu, Qian, Li, Nan, Xu, Ming, Miyamoto, Tatsuo, Liu, Jing

“…Breast cancer metastasis is the main cause of cancer death in women, so far, no effective treatment has inhibited breast cancer metastasis. Sulforaphane (SFN),…”
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Imaging of the Ciliary Cholesterol Underlying the Sonic Hedgehog Signal Transduction by Miyamoto, Tatsuo, Hosoba, Kosuke, Akutsu, Silvia Natsuko, Matsuura, Shinya

“…Primary cilia are antenna-like structures that develop on the surface of quiescent G -phase cells and receive extracellular signals including sonic hedgehog…”
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The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation by Miyamoto, Tatsuo, Hosoba, Kosuke, Ochiai, Hiroshi, Royba, Ekaterina, Izumi, Hideki, Sakuma, Tetsushi, Yamamoto, Takashi, Dynlacht, Brian David, Matsuura, Shinya

“…The primary cilium is an antenna-like, microtubule-based organelle on the surface of most vertebrate cells for receiving extracellular information. Although…”
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Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome by Miyamoto, Tatsuo, Hosoba, Kosuke, Itabashi, Takeshi, Iwane, Atsuko H, Akutsu, Silvia Natsuko, Ochiai, Hiroshi, Saito, Yumiko, Yamamoto, Takashi, Matsuura, Shinya

“…Primary cilia are antenna‐like organelles on the surface of most mammalian cells that receive sonic hedgehog (Shh) signaling in embryogenesis and…”
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iPSC reprogramming-mediated aneuploidy correction in autosomal trisomy syndromes by Akutsu, Silvia Natsuko, Miyamoto, Tatsuo, Oba, Daiju, Tomioka, Keita, Ochiai, Hiroshi, Ohashi, Hirofumi, Matsuura, Shinya

“…Trisomy 21, 18, and 13 are the major autosomal aneuploidy disorders in humans. They are mostly derived from chromosome non-disjunction in maternal meiosis, and…”
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Space Radiation Biology for “Living in Space” by Furukawa, Satoshi, Nagamatsu, Aiko, Nenoi, Mitsuru, Fujimori, Akira, Kakinuma, Shizuko, Katsube, Takanori, Wang, Bing, Tsuruoka, Chizuru, Shirai, Toshiyuki, Nakamura, Asako J., Sakaue-Sawano, Asako, Miyawaki, Atsushi, Harada, Hiroshi, Kobayashi, Minoru, Kobayashi, Junya, Kunieda, Takekazu, Funayama, Tomoo, Suzuki, Michiyo, Miyamoto, Tatsuo, Hidema, Jun, Yoshida, Yukari, Takahashi, Akihisa

“…Space travel has advanced significantly over the last six decades with astronauts spending up to 6 months at the International Space Station. Nonetheless, the…”
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Efficient TALEN construction and evaluation methods for human cell and animal applications by Sakuma, Tetsushi, Hosoi, Sayaka, Woltjen, Knut, Suzuki, Ken‐ichi, Kashiwagi, Keiko, Wada, Housei, Ochiai, Hiroshi, Miyamoto, Tatsuo, Kawai, Narudo, Sasakura, Yasunori, Matsuura, Shinya, Okada, Yasushi, Kawahara, Atsuo, Hayashi, Shigeo, Yamamoto, Takashi

“…Transcription activator–like effector nucleases (TALENs) have recently arisen as effective tools for targeted genome engineering. Here, we report streamlined…”
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NBS1 I171V variant underlies individual differences in chromosomal radiosensitivity within human populations by Tomioka, Keita, Miyamoto, Tatsuo, Akutsu, Silvia Natsuko, Yanagihara, Hiromi, Fujita, Kazumasa, Royba, Ekaterina, Tauchi, Hiroshi, Yamamoto, Takashi, Koh, Iemasa, Hirata, Eiji, Kudo, Yoshiki, Kobayashi, Masao, Okada, Satoshi, Matsuura, Shinya

“…Genetic information is protected against a variety of genotoxins including ionizing radiation (IR) through the DNA double-strand break (DSB) repair machinery…”
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High-efficient CRISPR/Cas9-mediated gene targeting to establish cell models of ciliopathies by Hosoba, Kosuke, Morita, Tomoka, Zhang, Ying, Kishi, Hiroko, Yamamoto, Takashi, Miyamoto, Tatsuo

“…Primary cilia are antenna-like structures developed on the cell surface of mammalian cells during the quiescent G phase. Primary cilia in mammalian cells…”
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AT-hook DNA-binding motif-containing protein one knockdown downregulates EWS-FLI1 transcriptional activity in Ewing’s sarcoma cells by Kitagawa, Takao, Kobayashi, Daiki, Baron, Byron, Okita, Hajime, Miyamoto, Tatsuo, Takai, Rie, Paudel, Durga, Ohta, Tohru, Asaoka, Yoichi, Tokunaga, Masayuki, Nakagawa, Koji, Furutani-Seiki, Makoto, Araki, Norie, Kuramitsu, Yasuhiro, Kobayashi, Masanobu

“…Ewing’s sarcoma is the second most common bone malignancy in children or young adults and is caused by an oncogenic transcription factor by a chromosomal…”
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PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation by Miyamoto, Tatsuo, Akutsu, Silvia Natsuko, Fukumitsu, Akihiro, Morino, Hiroyuki, Masatsuna, Yoshinori, Hosoba, Kosuke, Kawakami, Hideshi, Yamamoto, Takashi, Shimizu, Kenji, Ohashi, Hirofumi, Matsuura, Shinya

“…Primary microcephaly (MCPH) is an autosomal recessive disorder characterized by congenital reduction of head circumference. Here, we identified compound…”
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Fatal Community-Acquired Clostridioides difficile Infection as a Cause of Listeria Meningitis: A Case Report by Naraoka, Kai, Ikenouchi, Hajime, Miyamoto, Tatsuo, Ikeda, Kensho, Endo, Kaoru

“…A 77-year-old woman with a history of total gastrectomy was transferred to our hospital with complaints of fever and consciousness disturbance for five days…”
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Cytoskeleton-related regulation of primary cilia shortening mediated by melanin-concentrating hormone receptor 1 by Tomoshige, Sakura, Kobayashi, Yuki, Hosoba, Kosuke, Hamamoto, Akie, Miyamoto, Tatsuo, Saito, Yumiko

“…Primary cilia are specialized microtubule-based organelles. Their importance is highlighted by the gamut of ciliary diseases associated with various syndromes…”
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Updated summary of genome editing technology in human cultured cells linked to human genetics studies by Miyamoto, Tatsuo, Akutsu, Silvia Natsuko, Matsuura, Shinya

“…Current deep-sequencing technology provides a mass of nucleotide variations associated with human genetic disorders to accelerate the identification of…”
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Evaluation of ATM heterozygous mutations underlying individual differences in radiosensitivity using genome editing in human cultured cells by Royba, Ekaterina, Miyamoto, Tatsuo, Natsuko Akutsu, Silvia, Hosoba, Kosuke, Tauchi, Hiroshi, Kudo, Yoshiki, Tashiro, Satoshi, Yamamoto, Takashi, Matsuura, Shinya

“…Ionizing radiation (IR) induces DNA double-strand breaks (DSBs), which are an initial step towards chromosomal aberrations and cell death. It has been…”
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A Case Report of Deep Cerebral Venous Thrombosis Presenting Unilateral Lesion: The Association of Asymmetric Venous Outflow and Unilateral Lesion by Oshima, Seiya, Ikenouchi, Hajime, Miyamoto, Tatsuo, Yamamoto, Naoki, Endo, Kaoru

“…A 60-year-old man was admitted to our hospital due to progressive aphasia and right hemiparesis. Brain magnetic resonance imaging showed the left thalamus and…”
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TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS (MVA) syndrome by Ochiai, Hiroshi, Miyamoto, Tatsuo, Kanai, Akinori, Hosoba, Kosuke, Sakuma, Tetsushi, Kudo, Yoshiki, Asami, Keiko, Ogawa, Atsushi, Watanabe, Akihiro, Kajii, Tadashi, Yamamoto, Takashi, Matsuura, Shinya

“…Cancer-prone syndrome of premature chromatid separation with mosaic variegated aneuploidy [PCS (MVA) syndrome] is a rare autosomal recessive disorder…”
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Steroid Rebound Phenomenon as a Cause of Delayed Cerebral Vasospasm in Post-Splenectomy Pneumococcal Meningitis: A Case Report by Yokoyama, Daiki, Ikenouchi, Hajime, Miyamoto, Tatsuo, Yamamoto, Naoki, Endo, Kaoru

“…Pneumococcal meningitis as an overwhelming post-splenectomy infection (OPSI) has a higher risk of neurological complications and is sometimes life-threatening…”
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Coordinated regulation of the dorsal‐ventral and anterior‐posterior patterning of Xenopus embryos by the BTB/POZ zinc finger protein Zbtb14 by Takebayashi‐Suzuki, Kimiko, Konishi, Hidenori, Miyamoto, Tatsuo, Nagata, Tomoko, Uchida, Misa, Suzuki, Atsushi

“…During early vertebrate embryogenesis, bone morphogenetic proteins (BMPs) belonging to the transforming growth factor‐β (TGF‐β) family of growth factors play a…”
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Progressive Small Vessel Disease Burden as a Diagnostic of Central Nervous System-Restricted Microscopic Polyangiitis: A Case Report and Review of the Literature by Hoshi, Haruka, Ikenouchi, Hajime, Yamamoto, Naoki, Miyamoto, Tatsuo, Endo, Kaoru

“…Microscopic polyangiitis (MPA) is a type of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis linked to myeloperoxidase (MPO), usually…”
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