Search Results - "Miyamoto, David K."

GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and Pathogenicity by Louie, Sharon M, Grossman, Elizabeth A, Crawford, Lisa A, Ding, Lucky, Camarda, Roman, Huffman, Tucker R, Miyamoto, David K, Goga, Andrei, Weerapana, Eranthie, Nomura, Daniel K

“…Breast cancers possess fundamentally altered metabolism that fuels their pathogenicity. While many metabolic drivers of breast cancers have been identified,…”
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Chemoproteomic Screening of Covalent Ligands Reveals UBA5 As a Novel Pancreatic Cancer Target by Roberts, Allison M, Miyamoto, David K, Huffman, Tucker R, Bateman, Leslie A, Ives, Ashley N, Akopian, David, Heslin, Martin J, Contreras, Carlo M, Rape, Michael, Skibola, Christine F, Nomura, Daniel K

“…Chemical genetic screening of small-molecule libraries has been a promising strategy for discovering unique and novel therapeutic compounds. However,…”
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Covalent Ligand Discovery against Druggable Hotspots Targeted by Anti-cancer Natural Products by Grossman, Elizabeth A, Ward, Carl C, Spradlin, Jessica N, Bateman, Leslie A, Huffman, Tucker R, Miyamoto, David K, Kleinman, Jordan I, Nomura, Daniel K

“…Many natural products that show therapeutic activities are often difficult to synthesize or isolate and have unknown targets, hindering their development as…”
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Design and Development of IKZF2 and CK1α Dual Degraders by Miyamoto, David K., Curnutt, Nicole M., Park, Sun-Mi, Stavropoulos, Alexios, Kharas, Michael G., Woo, Christina M.

“…Lenalidomide achieves its therapeutic efficacy by recruiting and removing proteins of therapeutic interest through the E3 ligase substrate adapter cereblon…”
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Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells by Park, Sun-Mi, Miyamoto, David K., Han, Grace Y.Q., Chan, Mandy, Curnutt, Nicole M., Tran, Nathan L., Velleca, Anthony, Kim, Jun Hyun, Schurer, Alexandra, Chang, Kathryn, Xu, Wenqing, Kharas, Michael G., Woo, Christina M.

“…Acute myeloid leukemia (AML) is a hematologic malignancy for which several epigenetic regulators have been identified as therapeutic targets. Here we report…”
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Discovery of a Celecoxib Binding Site on Prostaglandin E Synthase (PTGES) with a Cleavable Chelation-Assisted Biotin Probe by Miyamoto, David K, Flaxman, Hope A, Wu, Hung-Yi, Gao, Jinxu, Woo, Christina M

“…The coxibs are a subset of nonsteroidal anti-inflammatory drugs (NSAIDs) that primarily target cyclooxygenase-2 (COX-2) to inhibit prostaglandin signaling and…”
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Chemical Genetics Screening Reveals KIAA1363 as a Cytokine-Lowering Target by Hunerdosse, Devon M, Morris, Patrick J, Miyamoto, David K, Fisher, Karl J, Bateman, Leslie A, Ghazaleh, Jonathan R, Zhong, Sharon, Nomura, Daniel K

“…Inflammation is a hallmark of many human diseases, including pain, arthritis, atherosclerosis, obesity and diabetes, cancer, and neurodegenerative diseases…”
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