Tacrolimus Ointment for Refractory Posterior Blepharitis

Tacrolimus Ointment for Refractory Posterior Blepharitis

Purpose: This prospective, randomized, double-blind interventional case series was designed to evaluate the short-term efficacy of 0.03% tacrolimus ointment as a new therapeutic approach for refractory cases of posterior blepharitis. Methods: Forty eyes (20 patients) with posterior blepharitis refra...

Full description

Saved in:
Bibliographic Details
Published in:Current eye research Vol. 42; no. 11; pp. 1440 - 1444
Main Authors: Sakassegawa-Naves, Fernando Eiji, Ricci, Helena Maria Moraes, Moscovici, Bernardo Kaplan, Miyamoto, Daniela Akemi, Chiacchio, Brenda Biagio, Holzchuh, Ricardo, Santo, Ruth Muyuki, Hida, Richard Yudi
Format: Journal Article
Language:English
Published: England Taylor & Francis 02-11-2017
Subjects:
Administration, Topical
Adult
Blepharitis
Blepharitis - drug therapy
Blepharitis - pathology
Dose-Response Relationship, Drug
Double-Blind Method
Female
Follow-Up Studies
Humans
Immunosuppressive Agents - administration & dosage
Male
meibomian gland dysfunction
Meibomian Glands - drug effects
Meibomian Glands - pathology
Middle Aged
Ointments
posterior blepharitis
Prospective Studies
Slit Lamp Microscopy
tacrolimus
Tacrolimus - administration & dosage
Treatment Outcome
Blepharitis
meibomian gland dysfunction
posterior blepharitis
tacrolimus
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose: This prospective, randomized, double-blind interventional case series was designed to evaluate the short-term efficacy of 0.03% tacrolimus ointment as a new therapeutic approach for refractory cases of posterior blepharitis. Methods: Forty eyes (20 patients) with posterior blepharitis refractory to previous treatment were randomized. Eighteen eyes (9 patients) were treated with 0.03% tacrolimus ointment and 20 eyes (10 patients) with placebo ointment twice daily. Patients were evaluated with a questionnaire and slit-lamp examination 14 days and 28 days after treatment, and symptoms and signs of blepharitis were compared to those observed at baseline. Results: We could observe statistical difference in the outcome measurements of meibomian gland secretion, conjunctival hyperemia, telangiectasia of inferior lid, Rose Bengal, and fluorescein scoring for the study group. As for the symptoms score, we observed statistical difference in the symptoms scoring for pruritus and dry eye sensation in the tacrolimus group. Conclusion: This study suggests that topical administration of 0.03% tacrolimus ointment can improve some symptoms and some ocular surface status in patients with refractory posterior blepharitis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
content type line 23
ISSN:0271-3683
1460-2202
DOI:10.1080/02713683.2017.1339805