Search Results - "Miyamoto, B."

Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models by Li, Fu, Emmerton, Kim K, Jonas, Mechthild, Zhang, Xinqun, Miyamoto, Jamie B, Setter, Jocelyn R, Nicholas, Nicole D, Okeley, Nicole M, Lyon, Robert P, Benjamin, Dennis R, Law, Che-Leung

“…Antibody-drug conjugates (ADC) comprise targeting antibodies armed with potent small-molecule payloads. ADCs demonstrate specific cell killing in clinic, but…”
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Orthogonal Cysteine Protection Enables Homogeneous Multi‐Drug Antibody–Drug Conjugates by Levengood, Matthew R., Zhang, Xinqun, Hunter, Joshua H., Emmerton, Kim K., Miyamoto, Jamie B., Lewis, Timothy S., Senter, Peter D.

“…A strategy for the preparation of homogeneous antibody–drug conjugates (ADCs) containing multiple payloads has been developed. This approach utilizes…”
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Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate by OKELEY, Nicole M, MIYAMOTO, Jamie B, XINQUN ZHANG, SANDERSON, Russell J, BENJAMIN, Dennis R, SIEVERS, Eric L, SENTER, Peter D, ALLEY, Stephen C

“…Purpose: SGN-35 is an antibody-drug conjugate (ADC) containing the potent antimitotic drug, monomethylauristatin E (MMAE), linked to the anti-CD30 monoclonal…”
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Optimization of a PEGylated Glucuronide-Monomethylauristatin E Linker for Antibody-Drug Conjugates by Burke, Patrick J, Hamilton, Joseph Z, Jeffrey, Scott C, Hunter, Joshua H, Doronina, Svetlana O, Okeley, Nicole M, Miyamoto, Jamie B, Anderson, Martha E, Stone, Ivan J, Ulrich, Michelle L, Simmons, Jessica K, McKinney, Erica E, Senter, Peter D, Lyon, Robert P

“…The emergence of antibody-drug conjugates (ADC), such as brentuximab vedotin and ado-trastuzumab emtansine, has led to increased efforts to identify new…”
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SGN-LIV1A: a novel antibody-drug conjugate targeting LIV-1 for the treatment of metastatic breast cancer by Sussman, Django, Smith, Leia M, Anderson, Martha E, Duniho, Steve, Hunter, Joshua H, Kostner, Heather, Miyamoto, Jamie B, Nesterova, Albina, Westendorf, Lori, Van Epps, Heather A, Whiting, Nancy, Benjamin, Dennis R

“…In this article, we describe a novel antibody-drug conjugate (ADC; SGN-LIV1A), targeting the zinc transporter LIV-1 (SLC39A6) for the treatment of metastatic…”
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Anti-leukemic activity of Lintuzumab (SGN-33) in preclinical models of acute myeloid leukemia by Sutherland, May Kung, Yu, Changpu, Lewis, Timothy S., Miyamoto, Jamie B., Morris-Tilden, Carol A., Jonas, Mechthild, Sutherland, Jennifer, Nesterova, Albina, Gerber, Hans-Peter, Sievers, Eric L., Grewal, Iqbal S., Law, Che-Leung

“…Despite therapeutic advances, the long-term survival rates for acute myeloid leukemia (AML) are estimated to be 10% or less, pointing to the need for better…”
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A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology by Jeffrey, Scott C, Burke, Patrick J, Lyon, Robert P, Meyer, David W, Sussman, Django, Anderson, Martha, Hunter, Joshua H, Leiske, Chris I, Miyamoto, Jamie B, Nicholas, Nicole D, Okeley, Nicole M, Sanderson, Russell J, Stone, Ivan J, Zeng, Weiping, Gregson, Stephen J, Masterson, Luke, Tiberghien, Arnaud C, Howard, Philip W, Thurston, David E, Law, Che-Leung, Senter, Peter D

“…A highly cytotoxic DNA cross-linking pyrrolobenzodiazepine (PBD) dimer with a valine-alanine dipeptide linker was conjugated to the anti-CD70 h1F6 mAb either…”
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The Methylene Alkoxy Carbamate Self-Immolative Unit: Utilization for the Targeted Delivery of Alcohol-Containing Payloads with Antibody-Drug Conjugates by Kolakowski, Robert V., Haelsig, Karl T., Emmerton, Kim K., Leiske, Chris I., Miyamoto, Jamie B., Cochran, Julia H., Lyon, Robert P., Senter, Peter D., Jeffrey, Scott C.

“…A strategy for the conjugation of alcohol‐containing payloads to antibodies has been developed and involves the methylene alkoxy carbamate (MAC)…”
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Novel Auristatins with High Bystander and Cytotoxic Activities in Drug Efflux-positive Tumor Models by Moquist, Philip N, Bovee, Tim D, Waight, Andrew B, Mitchell, Jamie A, Miyamoto, Jamie B, Mason, Marsha L, Emmerton, Kim K, Stevens, Nicole, Balasubramanian, Cindy, Simmons, Jessica K, Lyon, Robert P, Senter, Peter D, Doronina, Svetlana O

“…Auristatins, a class of clinically validated anti-tubulin agents utilized as payloads in antibody-drug conjugates, are generally classified by their membrane…”
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Machine vision to identify broiler breeder behavior by Pereira, Danilo F, Miyamoto, Bruno C.B, Maia, Guilherme D.N, Tatiana Sales, G, Magalhães, Marcelo M, Gates, Richard S

“…•The behavior can be applied to estimate the animal welfare.•The observation of behaviors can be exhausting for human.•We combined technique of image analysis…”
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Design, Synthesis, and Biological Evaluation of Antibody−Drug Conjugates Comprised of Potent Camptothecin Analogues by Burke, Patrick J, Senter, Peter D, Meyer, David W, Miyamoto, Jamie B, Anderson, Martha, Toki, Brian E, Manikumar, Govindarajan, Wani, Mansukh C, Kroll, David J, Jeffrey, Scott C

“…Antibody−drug conjugates (ADCs) were prepared with potent camptothecin analogues attached to monoclonal antibodies (mAbs) via dipeptide or glucuronide-based…”
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Minor groove binder antibody conjugates employing a water soluble β-glucuronide linker by Jeffrey, Scott C., Nguyen, Minh T., Moser, Ruth F., Meyer, Damon L., Miyamoto, Jamie B., Senter, Peter D.

“…The minor groove binder β-glucuronide drug-linker 3 was constructed from amino CBI 1 and determined to be a substrate for Escherichia coli β-glucuronidase (EC…”
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Novel Peptide Linkers for Highly Potent Antibody−Auristatin Conjugate by Doronina, Svetlana O, Bovee, Tim D, Meyer, David W, Miyamoto, Jamie B, Anderson, Martha E, Morris-Tilden, Carol A, Senter, Peter D

“…Auristatins are highly potent antimitotic agents that have received considerable attention because of their activities when targeted to tumor cells in the form…”
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Orthogonal Cysteine Protection Enables Homogeneous Multi‐Drug Antibody–Drug Conjugates by Levengood, Matthew R., Zhang, Xinqun, Hunter, Joshua H., Emmerton, Kim K., Miyamoto, Jamie B., Lewis, Timothy S., Senter, Peter D.

“…A strategy for the preparation of homogeneous antibody–drug conjugates (ADCs) containing multiple payloads has been developed. This approach utilizes…”
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Novel immunoconjugates comprised of streptonigrin and 17-amino-geldanamycin attached via a dipeptide- p-aminobenzyl-amine linker system by Burke, Patrick J., Toki, Brian E., Meyer, David W., Miyamoto, Jamie B., Kissler, Kim M., Anderson, Martha, Senter, Peter D., Jeffrey, Scott C.

“…Cytotoxic agents streptonigrin and 17-amino-geldanamycin were linked to monoclonal antibodies (mAbs), forming antibody–drug conjugates (ADCs) for…”
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The Methylene Alkoxy Carbamate Self-Immolative Unit: Utilization for the Targeted Delivery of Alcohol-Containing Payloads with Antibody-Drug Conjugates by Kolakowski, Robert V., Haelsig, Karl T., Emmerton, Kim K., Leiske, Chris I., Miyamoto, Jamie B., Cochran, Julia H., Lyon, Robert P., Senter, Peter D., Jeffrey, Scott C.

“…A strategy for the conjugation of alcohol‐containing payloads to antibodies has been developed and involves the methylene alkoxy carbamate (MAC)…”
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Properties of the myc-gene product: nuclear association, inhibition of transcription and activation in stimulated lymphocytes by Moelling, K, Benter, T, Bunte, T, Pfaff, E, Deppert, W, Egly, J M, Miyamoto, N B

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Abstract 4634: Engineered cysteine drug conjugates show potency and improved safety by Sussman, Django, Torrey, Lindsay, Westendorf, Lori, Miyamoto, Jaime B., Meyer, David W., Lyon, Robert, Duniho, Steve, Hayes, Dawn C., Anderson, Martha, Benjamin, Dennis R.

“…Antibody-drug conjugates (ADCs) are emerging as an important therapeutic option for new oncology drugs. In this abstract we present data on engineered cysteine…”
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Abstract 3962: SGN-LIV1A: a development stage antibody drug-conjugate targeting LIV-1 for the treatment of metastatic breast cancer by Sussman, Django, Smith, Leia M., Anderson, Martha E., Duniho, Steve, Hunter, Joshua H., Kostner, Heather, Miyamoto, Jamie B., Nesterova, Albina, Westendorf, Lori, Van Epps, Heather A., Whiting, Nancy, Benjamin, Dennis R.

“…LIV-1, also known as SLC39A6 or ZIP6, is a member of the zinc transporter family and was first identified as an estrogen-inducible gene in breast cancer…”
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Abstract B204: Engineered cysteine antibodies: Improved antibody-drug conjugate vehicles by Sussman, Django, Torrey, Lindsay, Westendorf, Lori, Zhang, Xinqun, Okeley, Nicole M., Alley, Stephen C., Lyon, Robert, Meyer, David, Miyamoto, Jamie B., Benjamin, Dennis R.

“…The use of monoclonal antibodies for the delivery of anticancer drugs to tumor cells is an emerging therapeutic modality and has been the subject of a great…”
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