Search Results - "Miyagawa, Jun‐Ichiro"

Postabsorptive hyperglucagonemia in patients with type 2 diabetes mellitus analyzed with a novel enzyme‐linked immunosorbent assay by Matsuo, Toshihiro, Miyagawa, Jun‐ichiro, Kusunoki, Yoshiki, Miuchi, Masayuki, Ikawa, Takashi, Akagami, Takafumi, Tokuda, Masaru, Katsuno, Tomoyuki, Kushida, Akira, Inagaki, Takashi, Namba, Mitsuyoshi

“…Aims/introduction The aims of the present study were to investigate the performance of a novel sandwich enzyme‐linked immunosorbent assay (ELISA) for measuring…”
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Lipid droplet accumulation in β cells in patients with type 2 diabetes is associated with insulin resistance, hyperglycemia and β cell dysfunction involving decreased insulin granules by Horii, Tomomi, Kozawa, Junji, Fujita, Yukari, Kawata, Satoshi, Ozawa, Harutoshi, Ishibashi, Chisaki, Yoneda, Sho, Nammo, Takao, Miyagawa, Jun-ichiro, Eguchi, Hidetoshi, Shimomura, Iichiro

“…Background and objective Pancreatic fat is a form of ectopic fat. Lipid droplets (LDs) are also observed in β cells; however, the pathophysiological…”
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Add-on therapy with the DPP-4 inhibitor sitagliptin improves glycemic control in insulin-treated Japanese patients with type 2 diabetes mellitus by Katsuno, Tomoyuki, Ikeda, Hiroki, Ida, Kenichi, Miyagawa, Jun-ichiro, Namba, Mitsuyoshi

“…The effect of add-on therapy with sitagliptin on glycemic control was prospectively investigated in patients with type 2 diabetes mellitus (T2DM) receiving…”
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The tetraspanin CD9 modulates epidermal growth factor receptor signaling in cancer cells by Murayama, Yoko, Shinomura, Yasuhisa, Oritani, Kenji, Miyagawa, Jun-Ichiro, Yoshida, Hitoshi, Nishida, Makoto, Katsube, Fumie, Shiraga, Masamichi, Miyazaki, Tamana, Nakamoto, Taisei, Tsutsui, Shusaku, Tamura, Shinji, Higashiyama, Shigeki, Shimomura, Iichirou, Hayashi, Norio

“…CD9 is a member of the tetraspanins, and has been shown to be involved in a variety of cellular activities such as migration, proliferation, and adhesion. In…”
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Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity by Arita, Yukio, Kihara, Shinji, Ouchi, Noriyuki, Takahashi, Masahiko, Maeda, Kazuhisa, Miyagawa, Jun-ichiro, Hotta, Kikuko, Shimomura, Iichiro, Nakamura, Tadashi, Miyaoka, Koji, Kuriyama, Hiroshi, Nishida, Makoto, Yamashita, Shizuya, Okubo, Kosaku, Matsubara, Kenji, Muraguchi, Masahiro, Ohmoto, Yasuichi, Funahashi, Tohru, Matsuzawa, Yuji

“…We isolated the human adipose-specific and most abundant gene transcript, apM1 (Maeda, K., et al.,Biochem. Biophys. Res. Commun.221, 286–289, 1996). The apM1…”
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Significance of the regulation of hyperglucagonemia in type 2 diabetes mellitus by Miuchi, Masayuki, Miyagawa, Jun-ichiro, Namba, Mitsuyoshi

“…Abstract Generally, pancreatic β-cell dysfunction and hypoinsulinemia have been known as the cause of development of hyperglycemia in diabetes mellitus…”
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Effects of the naturally-occurring disaccharides, palatinose and sucrose, on incretin secretion in healthy non-obese subjects by Maeda, Aya, Miyagawa, Jun-ichiro, Miuchi, Masayuki, Nagai, Etsuko, Konishi, Kosuke, Matsuo, Toshihiro, Tokuda, Masaru, Kusunoki, Yoshiki, Ochi, Humihiro, Murai, Kazuki, Katsuno, Tomoyuki, Hamaguchi, Tomoya, Harano, Yutaka, Namba, Mitsuyoshi

“…Aims/Introduction Incretins might play some pathophysiological role in glucose metabolism in diabetes and obesity; it is not clear whether or not the amount…”
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The HNF-1 target Collectrin controls insulin exocytosis by SNARE complex formation by Fukui, Kenji, Yang, Qin, Cao, Yang, Takahashi, Noriko, Hatakeyama, Hiroyasu, Wang, Haiyan, Wada, Jun, Zhang, Yanling, Marselli, Lorella, Nammo, Takao, Yoneda, Kazue, Onishi, Mineki, Higashiyama, Shigeki, Matsuzawa, Yuji, Gonzalez, Frank J., Weir, Gordon C., Kasai, Haruo, Shimomura, Iichiro, Miyagawa, Jun-ichiro, Wollheim, Claes B., Yamagata, Kazuya

“…Defective glucose-stimulated insulin secretion is the main cause of hyperglycemia in type 2 diabetes mellitus. Mutations in HNF-1α cause a monogenic form of…”
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Evaluation of a minimally invasive system for measuring glucose area under the curve during oral glucose tolerance tests: usefulness of sweat monitoring for precise measurement by Sakaguchi, Kazuhiko, Hirota, Yushi, Hashimoto, Naoko, Ogawa, Wataru, Hamaguchi, Tomoya, Matsuo, Toshihiro, Miyagawa, Jun-ichiro, Namba, Mitsuyoshi, Sato, Toshiyuki, Okada, Seiki, Tomita, Koji, Matsuhisa, Munehide, Kaneto, Hideaki, Kosugi, Keisuke, Maegawa, Hiroshi, Nakajima, Hiromu, Kashiwagi, Atsunori

“…We developed a system for measuring glucose area under the curve (AUC) using minimally invasive interstitial fluid extraction technology (MIET). Sweat…”
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Ectodomain Shedding of Epidermal Growth Factor Receptor Ligands Is Required for Keratinocyte Migration in Cutaneous Wound Healing by Tokumaru, Sho, Higashiyama, Shigeki, Endo, Takeshi, Nakagawa, Takatoshi, Miyagawa, Jun-ichiro, Yamamori, Katsumi, Hanakawa, Yasushi, Ohmoto, Hiroshi, Yoshino, Kohichiro, Shirakata, Yuji, Matsuzawa, Yuji, Hashimoto, Koji, Taniguchi, Naoyuki

“…Keratinocyte proliferation and migration are essential to cutaneous wound healing and are, in part, mediated in an autocrine fashion by epidermal growth factor…”
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Effect of additional administration of acarbose on blood glucose fluctuations and postprandial hyperglycemia in patients with type 2 diabetes mellitus under treatment with alogliptin by Kusunoki, Yoshiki, Katsuno, Tomoyuki, Myojin, Makiko, Miyakoshi, Kana, Ikawa, Takashi, Matsuo, Toshihiro, Ochi, Fumihiro, Tokuda, Masaru, Murai, Kazuki, Miuchi, Masayuki, Hamaguchi, Tomoya, Miyagawa, Jun-ichiro, Namba, Mitsuyoshi

“…Acarbose was administered at 300 mg/day to patients with type 2 diabetes mellitus (T2DM) who had been taking 25 mg/day of alogliptin, and levels of blood…”
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Effects of exenatide on metabolic parameters/control in obese Japanese patients with type 2 diabetes by Tokuda, Masaru, Katsuno, Tomoyuki, Ochi, Fumihiro, Miyakoshi, Kana, Kusunoki, Yoshiki, Murai, Kazuki, Miuchi, Masayuki, Hamaguchi, Tomoya, Miyagawa, Jun-ichiro, Namba, Mitsuyoshi

“…The effects of exenatide on glycemic control, lipid metabolism, blood pressure, and gastrointestinal symptoms were investigated in obese Japanese patients with…”
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Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins by Yokota, Takafumi, Meka, C S Reddy, Medina, Kay L, Igarashi, Hideya, Comp, Phillip C, Takahashi, Masahiko, Nishida, Makoto, Oritani, Kenji, Miyagawa, Jun-Ichiro, Funahashi, Tohru, Tomiyama, Yoshiaki, Matsuzawa, Yuji, Kincade, Paul W

“…Adiponectin, an adipocyte-derived hormone, was recently shown to have potential therapeutic applications in diabetes and obesity because of its influence on…”
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New strategy for the treatment of type 2 diabetes mellitus with incretin-based therapy by Namba, Mitsuyoshi, Katsuno, Tomoyuki, Kusunoki, Yoshiki, Matsuo, Toshihiro, Miuchi, Masayuki, Miyagawa, Jun-ichiro

“…Incretin-based therapy was first made available for the treatment of type 2 diabetes mellitus (T2DM) in the US in 2006 and in Japan in 2009. Four DPP-4…”
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The -1535 Promoter Variant of The Visfatin Gene Is Associated with Serum Triglyceride and HDL-cholesterol Levels in Japanese Subjects by TOKUNAGA, Ayumi, MIURA, Atsuko, OKAUCHI, Yukiyoshi, SEGAWA, Katsumori, FUKUHARA, Atsunori, OKITA, Kohei, TAKAHASHI, Masahiko, FUNAHASHI, Tohru, MIYAGAWA, Jun-ichiro, SHIMOMURA, Iichiro, YAMAGATA, Kazuya

“…Visfatin is a novel adipocytokine that is expressed by the visceral fat cells. We investigated the role of genetic variation in the visfatin gene in the…”
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Overexpression of Dominant-Negative Mutant Hepatocyte Nuclear Factor-1α in Pancreatic β-Cells Causes Abnormal Islet Architecture With Decreased Expression of E-Cadherin, Reduced β-cell Proliferation, and Diabetes by YAMAGATA, Kazuya, NAMMO, Takao, IWAHASHI, Hiromi, ZHU, Qian, CAO, Yang, IMAGAWA, Akihisa, TOCHINO, Yoshihiro, HANAFUSA, Toshiaki, MIYAGAWA, Jun-Ichiro, MATSUZAWA, Yuji, MORIWAKI, Makoto, IHARA, Arisa, IIZUKA, Katsumi, YANG, Qin, SATOH, Tomomi, LI, Ming, UENAKA, Rikako, OKITA, Kohei

“…Overexpression of Dominant-Negative Mutant Hepatocyte Nuclear Factor-1α in Pancreatic β-Cells Causes Abnormal Islet Architecture With Decreased Expression of…”
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Effects of miglitol in combination with intensive insulin therapy on blood glucose control with special reference to incretin responses in type 1 diabetes mellitus by Nagai, Etsuko, Katsuno, Tomoyuki, Miyagawa, Jun-ichiro, Konishi, Kosuke, Miuchi, Masayuki, Ochi, Fumihiro, Kusunoki, Yoshiki, Tokuda, Masaru, Murai, Kazuki, Hamaguchi, Tomoya, Namba, Mitsuyoshi

“…To determine whether miglitol administration improves glycemic control and reduces the frequency of hypoglycemia in type 1 diabetes mellitus (T1DM) patients…”
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Therapeutic indications of incretin-related derivatives and other oral hypoglycemic agents by Katsuno, Tomoyuki, Miyagawa, Jun-Ichiro

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DPP-4 inhibitor (incretin enhancer) by Miyagawa, Jun-Ichiro, Namba, Mitsuyoshi

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Incretin-based therapy in patients with type 1 diabetes mellitus by Miyagawa, Jun-Ichiro, Miuchi, Masayuki, Namba, Mitsuyoshi

“…GLP-1 has multiple physiological functions including glucose-dependent insulin secretion and glucagon suppression, delay of gastic emptying, suppression of…”
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