Search Results - "Mixan, Bruce"

cAC10-vcMMAE, an anti-CD30–monomethyl auristatin E conjugate with potent and selective antitumor activity by Francisco, Joseph A., Cerveny, Charles G., Meyer, Damon L., Mixan, Bruce J., Klussman, Kerry, Chace, Dana F., Rejniak, Starr X., Gordon, Kristine A., DeBlanc, Ron, Toki, Brian E., Law, Che-Leung, Doronina, Svetlana O., Siegall, Clay B., Senter, Peter D., Wahl, Alan F.

“…The chimeric monoclonal antibody cAC10, directed against CD30, induces growth arrest of CD30+ cell lines in vitro and has pronounced antitumor activity in…”
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Preclinical antilymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40 by LAW, Che-Leung, GORDON, Kristine A, WANT, Alan F, GREWAL, Iqbal S, COLLIER, John, KLUSSMAN, Kerry, MCEARCHERN, Julie A, CERVENY, Charles G, MIXAN, Bruce J, LEE, Wyne P, ZHONGHAU LIN, VALDEZ, Patricia

“…SGN-40 is a humanized IgG1 antihuman CD40 that is currently in a phase I clinical trial for the treatment of multiple myeloma. As surface CD40 expression on…”
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Efficient Elimination of B-Lineage Lymphomas by Anti-CD20–Auristatin Conjugates by LAW, Che-Leung, CERVENY, Charles G, SENTER, Peter D, WAHL, Alan F, GORDON, Kristine A, KLUSSMAN, Kerry, MIXAN, Bruce J, CHACE, Dana F, MEYER, Damon L, DORONINA, Svetlana O, SIEGALL, Clay B, FRANCISCO, Joseph A

“…The anti-CD20 antibody rituximab is useful in the treatment of certain B-cell malignancies, most notably non-Hodgkin’s lymphoma. Its efficacy has been…”
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Identification and Activities of Human Carboxylesterases for the Activation of CPT-11, a Clinically Approved Anticancer Drug by Senter, Peter D, Beam, Kevin S, Mixan, Bruce, Wahl, Alan F

“…CPT-11 is a clinically approved anticancer drug used for the treatment of advanced colorectal cancer. Upon administration, the carbamate side chain of the drug…”
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Secondary mAb−vcMMAE Conjugates Are Highly Sensitive Reporters of Antibody Internalization via the Lysosome Pathway by Klussman, Kerry, Mixan, Bruce J, Cerveny, Charles G, Meyer, Damon L, Senter, Peter D, Wahl, Alan F

“…Monoclonal antibodies (mAb) selectively recognizing tumor surface antigens are an important and evolving approach to targeted cancer therapy. One application…”
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Selective tumor sensitization to taxanes with the mAb‐drug conjugate cBR96‐doxorubicin by Wahl, Alan F., Donaldson, Karen L., Mixan, Bruce J., Trail, Pamela A., Siegall, Clay B.

“…The chimeric monoclonal antibody cBR96 conjugated to doxorubicin (cBR96‐Dox) is selectively internalized by a wide variety of human carcinomas expressing an…”
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HER4 Expression Correlates with Cytotoxicity Directed by a Heregulin-Toxin Fusion Protein (∗) by Bacus, Sarah S., Chin, Dot M., Goetze, Andy, Siegall, Clay B., Cohen, Bruce D., Plowman, Gregory D., Mixan, Bruce, Chace, Dana, Green, Janell M., Hellström, Ingegerd, Hellström, Karl Erik, Fell, H. Perry

“…We have constructed, expressed, and purified a fusion protein, HAR-TX β2, consisting of heregulin-β2 fused to a binding-defective form of Pseudomonas exotoxin…”
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Seconcary mAb-vcMMAE conjugates are highly sensitive reporters of antibody internalization via the lysosome pathway by Klussman, Kerry, Mixan, Bruce J, Cerveny, Charles G, Meyer, Damon L

“…Monoclonal antibodies (mAb) selectively recognizing tumor surface antigens are an important and evolving approach to targeted cancer therapy. One application…”
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Characterization of vascular leak syndrome induced by the toxin component of Pseudomonas exotoxin-based immunotoxins and its potential inhibition with nonsteroidal anti-inflammatory drugs by SIEGALL, C. B, LIGGITT, D, CHACE, D, MIXAN, B, SUGAI, J, DAVIDSON, T, STEINITZ, M

“…Clinical trials of immunotoxins in cancer patients have been limited in many cases by vascular leak syndrome (VLS). Recently, rats were identified as a model…”
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Expression and Characterization of Bryodin 1 and a Bryodin 1-Based Single-Chain Immunotoxin from Tobacco Cell Culture by Francisco, Joseph A, Gawlak, Susan L, Miller, Michael, Bathe, Jessie, Russell, David, Chace, Dana, Mixan, Bruce, Zhao, Lei, Fell, H. Perry, Siegall, Clay B

“…Bryodin 1 (BD1) is a potent ribosome-inactivating protein (RIP) isolated from the plant Bryonia dioica. It is relatively nontoxic in rodents (LD50 > 40 mg/kg)…”
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Prevention of immunotoxin-induced immunogenicity by coadministration with CTLA4Ig enhances antitumor efficacy by Siegall, CB, Haggerty, HG, Warner, GL, Chace, D, Mixan, B, Linsley, PS, Davidson, T

“…Immunotoxins have shown promise as antitumor agents in clinical trials. However, they have not become part of standard cancer therapy because of factors that…”
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In vitro and in vivo characterization of BR96 sFv-PE40. A single-chain immunotoxin fusion protein that cures human breast carcinoma xenografts in athymic mice and rats by Siegall, CB, Chace, D, Mixan, B, Garrigues, U, Wan, H, Paul, L, Wolff, E, Hellstrom, I, Hellstrom, KE

“…BR96 sFv-PE40 is a single-chain immunotoxin fusion protein targeted to the Ley Ag, which is expressed in many different human carcinomas as well as in normal…”
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Betacellulin-Pseudomonas toxin fusion proteins bind but are not cytotoxic to cells expressing HER4; correlation of EGFR for cytotoxic activity by MIXAN, B, COHEN, B. D, BACUS, S. S, FELL, H. P, SIEGALL, C. B

“…Betacellulin (BTC) is a member of the EGF ligand family that directly binds to both EGFR and HER4 and induces the growth of certain epithelial cell types…”
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Characterization of Ribosome-Inactivating Proteins Isolated from Bryonia dioica and Their Utility as Carcinoma-Reactive Immunoconjugates by Siegall, Clay B, Gawlak, Susan L, Chace, Dana, Wolff, Edith A, Mixan, Bruce, Marquardt, Hans

“…Two ribosome-inactivating proteins (RIPs) were isolated and characterized from the roots of Bryonia dioica. One of these was a novel 27-kDa protein termed…”
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