Search Results - "Miura, Shizuka"

Generation of Mouse and Human Organoid-Forming Intestinal Progenitor Cells by Direct Lineage Reprogramming by Miura, Shizuka, Suzuki, Atsushi

“…Intestinal organoids hold great promise as a valuable tool for studying and treating intestinal diseases. The currently available sources of human intestinal…”
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Transcription factor-mediated direct cellular reprogramming yields cell-type specific DNA methylation signature by Horisawa, Kenichi, Miura, Shizuka, Araki, Hiromitsu, Miura, Fumihito, Ito, Takashi, Suzuki, Atsushi

“…Direct reprogramming, inducing the conversion of one type of somatic cell into another by the forced expression of defined transcription factors, is a…”
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Induction of Steatohepatitis and Liver Tumorigenesis by Enforced Snail Expression in Hepatocytes by Miura, Shizuka, Suzuki, Atsushi

“…Snail is a transcription factor that regulates many cellular events involved in development, homeostasis, and disease. In hepatocellular carcinoma (HCC), Snail…”
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Hepatocytes differentiate into intestinal epithelial cells through a hybrid epithelial/mesenchymal cell state in culture by Miura, Shizuka, Horisawa, Kenichi, Iwamori, Tokuko, Tsujino, Satoshi, Inoue, Kazuya, Karasawa, Satsuki, Yamamoto, Junpei, Ohkawa, Yasuyuki, Sekiya, Sayaka, Suzuki, Atsushi

“…Hepatocytes play important roles in the liver, but in culture, they immediately lose function and dedifferentiate into progenitor-like cells. Although this…”
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Brief summary of the current protocols for generating intestinal organoids by Miura, Shizuka, Suzuki, Atsushi

“…The intestine has fundamental functions for the maintenance of homeostasis, including food digestion and nutrient/water absorption. Although the lumen of the…”
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Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells by Inada, Hiroki, Udono, Miyako, Matsuda-Ito, Kanae, Horisawa, Kenichi, Ohkawa, Yasuyuki, Miura, Shizuka, Goya, Takeshi, Yamamoto, Junpei, Nagasaki, Masao, Ueno, Kazuko, Saitou, Daisuke, Suyama, Mikita, Maehara, Yoshihiko, Kumamaru, Wataru, Ogawa, Yoshihiro, Sekiya, Sayaka, Suzuki, Atsushi

“…Recent advances have enabled the direct induction of human tissue-specific stem and progenitor cells from differentiated somatic cells. However, it is not…”
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Suppression of lethal‐7b and miR‐125a/b Maturation by Lin28b Enables Maintenance of Stem Cell Properties in Hepatoblasts by Takashima, Yasuo, Terada, Maiko, Udono, Miyako, Miura, Shizuka, Yamamoto, Junpei, Suzuki, Atsushi

“…In liver development, hepatoblasts that act as hepatic stem/progenitor cells proliferate and differentiate into both hepatocytes and cholangiocytes to form…”
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Secretory GFP reconstitution labeling of neighboring cells interrogates cell–cell interactions in metastatic niches by Minegishi, Misa, Kuchimaru, Takahiro, Nishikawa, Kaori, Isagawa, Takayuki, Iwano, Satoshi, Iida, Kei, Hara, Hiromasa, Miura, Shizuka, Sato, Marika, Watanabe, Shigeaki, Shiomi, Akifumi, Mabuchi, Yo, Hamana, Hiroshi, Kishi, Hiroyuki, Sato, Tatsuyuki, Sawaki, Daigo, Sato, Shigeru, Hanazono, Yutaka, Suzuki, Atsushi, Kohro, Takahide, Kadonosono, Tetsuya, Shimogori, Tomomi, Miyawaki, Atsushi, Takeda, Norihiko, Shintaku, Hirofumi, Kizaka-Kondoh, Shinae, Nishimura, Satoshi

“…Cancer cells inevitably interact with neighboring host tissue-resident cells during the process of metastatic colonization, establishing a metastatic niche to…”
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Cell Aggregation Culture Induces Functional Differentiation of Induced Hepatocyte-like Cells through Activation of Hippo Signaling by Yamamoto, Junpei, Udono, Miyako, Miura, Shizuka, Sekiya, Sayaka, Suzuki, Atsushi

“…Recent progress in direct lineage reprogramming has enabled the generation of induced hepatocyte-like (iHep) cells and revealed their potential as an…”
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Kupffer cells induce Notch-mediated hepatocyte conversion in a common mouse model of intrahepatic cholangiocarcinoma by Terada, Maiko, Horisawa, Kenichi, Miura, Shizuka, Takashima, Yasuo, Ohkawa, Yasuyuki, Sekiya, Sayaka, Matsuda-Ito, Kanae, Suzuki, Atsushi

“…Intrahepatic cholangiocarcinoma (ICC) is a malignant epithelial neoplasm composed of cells resembling cholangiocytes that line the intrahepatic bile ducts in…”
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Myofibroblasts Derived from Hepatic Progenitor Cells Create the Tumor Microenvironment by Sekiya, Sayaka, Miura, Shizuka, Matsuda-Ito, Kanae, Suzuki, Atsushi

“…Hepatic progenitor cells (HPCs) appear in response to several types of chronic injury in the human and rodent liver that often develop into liver fibrosis,…”
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Acquisition of lipid metabolic capability in hepatocyte-like cells directly induced from mouse fibroblasts by Miura, Shizuka, Suzuki, Atsushi

“…Recently, the numbers of patients with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have increased worldwide. NAFLD and…”
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Direct Lineage Reprogramming of Mouse Fibroblasts to Acquire the Identity of Fetal Intestine-Derived Progenitor Cells by Miura, Shizuka, Suzuki, Atsushi

“…Intestinal organoids are useful models for studying the characteristics of intestinal diseases and their treatment. However, a major limiting factor in their…”
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