Search Results - "Miu, Jenny"

Discovery of [11C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases by Tong, Ling, Li, Wenping, Lo, Michael Man-Chu, Gao, Xiaolei, Wai, Jenny Miu-Chen, Rudd, Michael, Tellers, David, Joshi, Aniket, Zeng, Zhizhen, Miller, Patricia, Salinas, Cristian, Riffel, Kerry, Haley, Hyking, Purcell, Mona, Holahan, Marie, Gantert, Liza, Schubert, Jeffrey W, Jones, Kristen, Mulhearn, James, Egbertson, Melissa, Meng, Zhaoyang, Hanney, Barbara, Gomez, Robert, Harrison, Scott T, McQuade, Paul, Bueters, Tjerk, Uslaner, Jason, Morrow, John, Thomson, Fiona, Kong, Jongrock, Liao, Jing, Selyutin, Oleg, Bao, Jianming, Hastings, Nicholas B, Agrawal, Sony, Magliaro, Brian C, Monsma, Frederick J, Smith, Michelle D, Risso, Stefania, Hesk, David, Hostetler, Eric, Mazzola, Robert

“…The measurement of receptor occupancy (RO) using positron emission tomography (PET) has been instrumental in guiding discovery and development of CNS directed…”
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Discovery, Optimization, and Biological Characterization of 2,3,6-Trisubstituted Pyridine-Containing M 4 Positive Allosteric Modulators by Schubert, Jeffrey W, Harrison, Scott T, Mulhearn, James, Gomez, Robert, Tynebor, Robert, Jones, Kristen, Bunda, Jaime, Hanney, Barbara, Wai, Jenny Miu-Chen, Cox, Chris, McCauley, John A, Sanders, John M, Magliaro, Brian, O'Brien, Julie, Pajkovic, Natasa, Huszar Agrapides, Sarah L, Taylor, Anne, Gotter, Anthony, Smith, Sean M, Uslaner, Jason, Browne, Susan, Risso, Stefania, Egbertson, Melissa

“…Herein we describe the discovery and optimization of a new series of 2,3-disubstituted and 2,3,6-trisubstituted muscarinic acetylcholine receptor 4 (M )…”
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Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice by Ball, Helen J., Sanchez-Perez, Angeles, Weiser, Silvia, Austin, Christopher J.D., Astelbauer, Florian, Miu, Jenny, McQuillan, James A., Stocker, Roland, Jermiin, Lars S., Hunt, Nicholas H.

“…Indoleamine 2,3-dioxygenase (INDO) and tryptophan 2,3-dioxygenase (TDO) each catalyze the first step in the kynurenine pathway of tryptophan metabolism. We…”
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Discovery, Optimization, and Biological Characterization of 2,3,6‐Trisubstituted Pyridine‐Containing M4 Positive Allosteric Modulators by Schubert, Jeffrey W., Harrison, Scott T., Mulhearn, James, Gomez, Robert, Tynebor, Robert, Jones, Kristen, Bunda, Jaime, Hanney, Barbara, Wai, Jenny Miu‐Chen, Cox, Chris, McCauley, John A., Sanders, John M., Magliaro, Brian, O'Brien, Julie, Pajkovic, Natasa, Huszar Agrapides, Sarah L., Taylor, Anne, Gotter, Anthony, Smith, Sean M., Uslaner, Jason, Browne, Susan, Risso, Stefania, Egbertson, Melissa

“…Herein we describe the discovery and optimization of a new series of 2,3‐disubstituted and 2,3,6‐trisubstituted muscarinic acetylcholine receptor 4 (M4)…”
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Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator by Rudd, Michael T., Manley, Peter J., Hanney, Barbara, Meng, Zhaoyang, Shu, Youheng, de Leon, Pablo, Frie, Jessica L., Han, Yongxin, Wai, Jenny Miu-Chun, Yang, Zhi-Qiang, Perkins, James J., Hurzy, Danielle M., Manikowski, Jesse J., Zhu, Hong, Bungard, Christopher J., Converso, Antonella, Meissner, Robert S., Cosden, Mali L., Hayashi, Ikuo, Ma, Lei, O’Brien, Julie, Uebele, Victor N., Schachter, Joel B., Bhandari, Neetesh, Ward, Gwendolyn J., Fillgrove, Kerry L., Lu, Bing, Liang, Yuexia, Dubost, David C., Puri, Vanita, Eddins, Donnie M., Vardigan, Joshua D., Drolet, Robert E., Kern, Jonathan T., Uslaner, Jason M.

“…Glutamate plays a key role in cognition and mood, and it has been shown that inhibiting ionotropic glutamate receptors disrupts cognition, while enhancing…”
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Chemokine Gene Expression during Fatal Murine Cerebral Malaria and Protection Due to CXCR3 Deficiency by Miu, Jenny, Mitchell, Andrew J, Muller, Marcus, Carter, Sally L, Manders, Peter M, McQuillan, James A, Saunders, Bernadette M, Ball, Helen J, Lu, Bao, Campbell, Iain L, Hunt, Nicholas H

“…Cerebral malaria (CM) can be a fatal manifestation of Plasmodium falciparum infection. Using murine models of malaria, we found much greater up-regulation of a…”
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Factors associated with cognitive function in older adults in Mexico by Miu, Jenny, Negin, Joel, Salinas-Rodriguez, Aarón, Manrique-Espinoza, Betty, Sosa-Ortiz, Ana Luisa, Cumming, Robert, Kowal, Paul

“…As populations age, cognitive decline and dementia pose significant burdens for societies and health care systems, including low- and middle-income countries…”
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Globus pallidus internus deep brain stimulation as rescue therapy for refractory dyskinesias following effective subthalamic nucleus stimulation by Cook, Raymond J, Jones, Lyndsey, Fracchia, George, Anderson, Nathan, Miu, Jenny, Meagher, Linton J, Silburn, Peter A, Silberstein, Paul

“…Deep brain stimulation (DBS) at the subthalamic nucleus (STN) or globus pallidus internus (GPi) can effectively treat the motor symptoms of Parkinson's…”
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Predominance of Interferon-Related Responses in the Brain during Murine Malaria, as Identified by Microarray Analysis by Miu, Jenny, Hunt, Nicholas H, Ball, Helen J

“…Cerebral malaria (CM) can be a fatal manifestation of Plasmodium falciparum infection. We examined global gene expression patterns during fatal murine CM…”
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Regulating the adaptive immune response to blood-stage malaria: role of dendritic cells and CD4⁺Foxp3⁺ regulatory T cells by Stevenson, Mary M, Ing, Rebecca, Berretta, Floriana, Miu, Jenny

“…Although a clearer understanding of the underlying mechanisms involved in protection and immunopathology during blood-stage malaria has emerged, the mechanisms…”
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Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria by Miu, Jenny, Ball, Helen J., Mellor, Andrew L., Hunt, Nicholas H.

“…Cerebral malaria (CM) can be a fatal manifestation of Plasmodium falciparum infection. In this study, two different approaches were used to examine the role of…”
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Chemokines and Malaria Infection by Miu, Jenny, Mitchell, Andrew J, Ball, Helen J, Hunt, Nicholas H

“…Malaria is a devastating disease of the tropics, with an estimated 3.2 billion people exposed to the threat of malaria. There are 1-3 million deaths annually,…”
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Ladder‐related injuries in New South Wales by Miu, Jenny, Dinh, Michael M, Curtis, Kate, Balogh, Zsolt J

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Immunopathogenesis of cerebral malaria by Hunt, Nicholas H., Golenser, Jacob, Chan-Ling, Tailoi, Parekh, Sapan, Rae, Caroline, Potter, Sarah, Medana, Isabelle M., Miu, Jenny, Ball, Helen J.

“…Malaria is one of the most important global health problems, potentially affecting more than one third of the world's population. Cerebral malaria (CM) is a…”
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Caspase-12 Dampens the Immune Response to Malaria Independently of the Inflammasome by Targeting NF-κB Signaling by Labbé, Katherine, Miu, Jenny, Yeretssian, Garabet, Serghides, Lena, Tam, Mifong, Finney, Constance A., Erdman, Laura K., Goulet, Marie-Line, Kain, Kevin C., Stevenson, Mary M., Saleh, Maya

“…Abstract Pathogen sensing by the inflammasome activates inflammatory caspases that mediate inflammation and cell death. Caspase-12 antagonizes the inflammasome…”
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Caspase-12 deficiency results in hyperinflammatory responses to lethal malaria by Miu, Jenny, Saleh, Maya, Stevenson, Mary M.

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Interferon-γ synergises with tumour necrosis factor and lymphotoxin-α to enhance the mRNA and protein expression of adhesion molecules in mouse brain endothelial cells by Weiser, Silvia, Miu, Jenny, Ball, Helen J., Hunt, Nicholas H.

“…Changes to the cerebral microvasculature are evident during cerebral malaria (CM). Activation of the endothelium is likely to be due to the actions of…”
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55 Inflammatory caspases modulate host response to malaria by Labbé, Katherine, Miu, Jenny, Tam, Mifong, Stevenson, Mary, Saleh, Maya

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Factors associated with cognitive function in older adults in Mexico by Miu, Jenny, Negin, Joel, Salinas-Rodriguez, Aarón, Manrique-Espinoza, Betty, Sosa-Ortiz, Ana Luisa, Cumming, Robert, Kowal, Paul

“…Background As populations age, cognitive decline and dementia pose significant burdens for societies and health care systems, including low- and middle-income…”
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Increased expression of indoleamine 2,3-dioxygenase in murine malaria infection is predominantly localised to the vascular endothelium by Hansen, Anna M., Ball, Helen J., Mitchell, Andrew J., Miu, Jenny, Takikawa, Osamu, Hunt, Nicholas H.

“…Products of the kynurenine pathway of tryptophan metabolism have been implicated in the pathogenesis of murine and human cerebral malaria. Indoleamine…”
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