Search Results - "Mittler, S"

Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection by Bohannon, Caitlin, Powers, Ryan, Satyabhama, Lakshmipriyadarshini, Cui, Ang, Tipton, Christopher, Michaeli, Miri, Skountzou, Ioanna, Mittler, Robert S., Kleinstein, Steven H., Mehr, Ramit, Lee, Frances Eun-Yun, Sanz, Ignacio, Jacob, Joshy

“…Long-lived plasma cells are critical to humoral immunity as a lifelong source of protective antibodies. Antigen-activated B cells—with T-cell help—undergo…”
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Soluble CD137 Ameliorates Acute Type 1 Diabetes by Inducing T Cell Anergy by Itoh, Arata, Ortiz, Lorenzo, Kachapati, Kritika, Wu, Yuehong, Adams, David, Bednar, Kyle, Mukherjee, Shibabrata, Chougnet, Claire, Mittler, Robert S, Chen, Yi-Guang, Dolan, Laurence, Ridgway, William M

“…We show here that soluble CD137 (sCD137), the alternately spliced gene product of , effectively treats acute type 1 diabetes (T1D) in nonobese diabetic (NOD)…”
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Eradication of established tumors in mice by a combination antibody-based therapy by Takeda, Kazuyoshi, Uno, Tomoyasu, Kojima, Yuko, Yoshizawa, Hirohisa, Akiba, Hisaya, Mittler, Robert S, Gejyo, Fumitake, Okumura, Ko, Yagita, Hideo, Smyth, Mark J

“…Tumor-cell apoptosis is the basis of many cancer therapies, and tumor-specific T cells are the principal effectors of successful antitumor immunotherapies…”
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Cytokine-Mediated Disruption of Lymphocyte Trafficking, Hemopoiesis, and Induction of Lymphopenia, Anemia, and Thrombocytopenia in Anti-CD137-Treated Mice by Niu, Liguo, Strahotin, Simona, Hewes, Becker, Zhang, Benyue, Zhang, Yuanyuan, Archer, David, Spencer, Trent, Dillehay, Dirck, Kwon, Byoung, Chen, Lieping, Vella, Anthony T, Mittler, Robert S

“…CD137-mediated signals costimulate T cells and protect them from activation-induced apoptosis; they induce curative antitumor immunity and enhance antiviral…”
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Reverse signaling through the costimulatory ligand CD137L in epithelial cells is essential for natural killer cell-mediated acute tissue inflammation by Kim, Hye J., Lee, Jong S., Kim, Jung D., Cha, Hee J., Kim, Ahra, Lee, Sun K., Lee, Sang C., Kwon, Byoung S., Mittler, Robert S., Cho, Hong R., Kwon, Byungsuk

“…Renal ischemia-reperfusion injury (IRI) after kidney transplantation is a major cause of delayed graft function. Even though IRI is recognized as a highly…”
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Integrated control of Heterodera schachtii Schmidt in Central Europe by trap crop cultivation, sugar beet variety choice and nematicide application by Hauer, M., Koch, H.-J., Krüssel, S., Mittler, S., Märländer, B.

“…•Nematode resistant mustard did not reduce H. schachtii any better than straw mulch.•Highest nematode reduction was achieved by growing a resistant sugar beet…”
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TLR2 signaling in tubular epithelial cells regulates NK cell recruitment in kidney ischemia-reperfusion injury by Kim, Hye J, Lee, Jong S, Kim, Ahra, Koo, Sumi, Cha, Hee J, Han, Jae-A, Do, Yoonkyung, Kim, Kyung M, Kwon, Byoung S, Mittler, Robert S, Cho, Hong R, Kwon, Byungsuk

“…Damage-associated molecular patterns released from damaged kidney cells initiate postischemic inflammation, an essential step in the progression of kidney…”
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Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells by Lee, Seung-Woo, Croft, Michael, So, Takanori, Cheroutre, Hilde, Mittler, Robert S, Kwon, Byoung S, Park, Yunji

“…The TNF receptor 4-1BB functions as a costimulatory molecule in T cells. Croft and colleagues show that binding of 4-1BB to its ligand regulates the production…”
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Cutting Edge: 4-1BB Is a Bona Fide CD8 T Cell Survival Signal by Takahashi, Chikara, Mittler, Robert S, Vella, Anthony T

“…After recognition of Ag/MHC and ligation of a costimulatory molecule, resting T cells will clonally expand and then delete to very low levels. Previously, it…”
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Cutting Edge: Expression of Functional CD137 Receptor by Dendritic Cells by Wilcox, Ryan A, Chapoval, Andrei I, Gorski, Kevin S, Otsuji, Mizuto, Shin, Tahiro, Flies, Dallas B, Tamada, Koji, Mittler, Robert S, Tsuchiya, Haruo, Pardoll, Drew M, Chen, Lieping

“…Interaction between dendritic cells (DCs) and T cells is a prerequisite for the initiation of a T cell response. The molecular nature of this interaction…”
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A Three-Dose Intramuscular Injection Schedule of Anthrax Vaccine Adsorbed Generates Sustained Humoral and Cellular Immune Responses to Protective Antigen and Provides Long-Term Protection against Inhalation Anthrax in Rhesus Macaques by Quinn, Conrad P, Sabourin, Carol L, Niemuth, Nancy A, Li, Han, Semenova, Vera A, Rudge, Thomas L, Mayfield, Heather J, Schiffer, Jarad, Mittler, Robert S, Ibegbu, Chris C, Wrammert, Jens, Ahmed, Rafi, Brys, April M, Hunt, Robert E, Levesque, Denyse, Estep, James E, Barnewall, Roy E, Robinson, David M, Plikaytis, Brian D, Marano, Nina

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Intracellular Trafficking of CTLA-4 and Focal Localization Towards Sites of TCR Engagement by Linsley, Peter S, Bradshaw, Jeff, Greene, JoAnne, Peach, Robert, Bennett, Kelly L, Mittler, Robert S

“…T lymphocyte receptor CTLA-4 binds costimulatory molecules CD80 (B7-1) and CD86 (B7-2) with high avidity and negatively regulates T cell activation. CTLA-4…”
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CD137-mediated immunotherapy for allergic asthma by Polte, Tobias, Foell, Juergen, Werner, Christoph, Hoymann, Heinz-Gerd, Braun, Armin, Burdach, Stefan, Mittler, Robert S, Hansen, Gesine

“…The prevalence of asthma continues to increase. Asthma is caused by a Th2 cell-driven immune response. Its optimal treatment remains a challenge, and a…”
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Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors by Melero, Ignacio, Shuford, Walter W, Newby, Stephanie Ashe, Aruffo, Alejandro, Ledbetter, Jeffrey A, Hellström, Karl Erik, Mittler, Robert S, Chen, Lieping

“…The 4-1BB glycoprotein is a member of the tumor necrosis factor receptor superfamily and binds to a high-affinity ligand (4-1BBL) expressed on several…”
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Mechanisms involved in synergistic anticancer effects of anti-4-1BB and cyclophosphamide therapy by Kim, Young H, Choi, Beom K, Oh, Ho S, Kang, Woo J, Mittler, Robert S, Kwon, Byoung S

“…Chemotherapy can precondition for immunotherapy by creating an environment for homeostatic lymphoproliferation and eliminating some of the suppressive immune…”
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Modulating Protective and Pathogenic CD4+ Subsets via CD137 in Type 1 Diabetes by IRIE, Junichiro, YUEHONG WU, KACHAPATI, Kritika, MITTLER, Robert S, RIDGWAY, William M

“…Modulating Protective and Pathogenic CD4 + Subsets via CD137 in Type 1 Diabetes Junichiro Irie 1 , Yuehong Wu 1 , Kritika Kachapati 1 , Robert S. Mittler 2 and…”
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NK1.1 Cells Express 4-1BB (CDw137) Costimulatory Molecule and Are Required for Tumor Immunity Elicited by Anti-4-1BB Monoclonal Antibodies by Melero, Ignacio, Johnston, Janet V., Shufford, Walter W., Mittler, Robert S., Chen, Lieping

“…The 4-1BB (CDw137) T-cell molecule is a member of the TNF receptor family and triggering by either 4-1BB ligand or antibody ligation induces T-cell activation…”
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3-D FDTD Analysis of Gold-Nanoparticle-Based Photonic Crystal on Slab Waveguide by Hao Jiang, Sabarinathan, J., Manifar, T., Mittler, S.

“…In this paper, metallic photonic crystals (PC) based on 2-D periodic arrays of gold nanoparticles were investigated on indium tin oxide slab waveguides using…”
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Effector CD8 T Cells Possess Suppressor Function after 4-1BB and Toll-like Receptor Triggering by Myers, Lara, Takahashi, Chikara, Mittler, Robert S., Rossi, Robert J., Vella, Anthony T.

“…To better understand how innate and adaptive immune responses interact with each other, we combined 4-1BB T cell costimulation with specific adjuvants to…”
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Engagement of 4-1BB Inhibits the Development of Experimental Allergic Conjunctivitis in Mice by Fukushima, Atsuki, Yamaguchi, Tomoko, Ishida, Waka, Fukata, Kazuyo, Mittler, Robert S, Yagita, Hideo, Ueno, Hisayuki

“…The 4-1BB receptor acts as a costimulator in CD8(+) T cell activation. Agonistic stimulation through this molecule by treatment with anti-4-1BB Abs has been…”
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