Search Results - "Mittendorf, Kathleen F"

Tolerance to Changes in Membrane Lipid Composition as a Selected Trait of Membrane Proteins by Sanders, Charles R, Mittendorf, Kathleen F

“…Membrane lipid composition can vary dramatically across the three domains of life and even within single organisms. Here we review evidence that the…”
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Impact of Bilayer Lipid Composition on the Structure and Topology of the Transmembrane Amyloid Precursor C99 Protein by Song, Yuanli, Mittendorf, Kathleen F, Lu, Zhenwei, Sanders, Charles R

“…C99 (also known as β-CTF) is the 99 residue transmembrane C-terminal domain (residues 672–770) of the amyloid precursor protein and is the immediate precursor…”
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Conformational Stability and Pathogenic Misfolding of the Integral Membrane Protein PMP22 by Schlebach, Jonathan P, Narayan, Malathi, Alford, Catherine, Mittendorf, Kathleen F, Carter, Bruce D, Li, Jun, Sanders, Charles R

“…Despite broad biochemical relevance, our understanding of the physiochemical reactions that limit the assembly and cellular trafficking of integral membrane…”
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Longitudinal adherence to breast cancer surveillance following cancer genetic testing in an integrated health care system by Knerr, Sarah, Guo, Boya, Wernli, Karen J., Mittendorf, Kathleen F., Feigelson, Heather Spencer, Gilmore, Marian J., Jarvik, Gail P., Kauffman, Tia L., Keast, Erin, Liles, Elizabeth G., Lynch, Frances L., Muessig, Kristin R., Okuyama, Sonia, Veenstra, David L., Zepp, Jamilyn M., Wilfond, Benjamin S., Devine, Beth, Goddard, Katrina A. B.

“…Purpose Screening with mammography and breast magnetic resonance imaging (MRI) is an important risk management strategy for individuals with inherited…”
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The Homology Model of PMP22 Suggests Mutations Resulting in Peripheral Neuropathy Disrupt Transmembrane Helix Packing by Mittendorf, Kathleen F, Kroncke, Brett M, Meiler, Jens, Sanders, Charles R

“…Peripheral myelin protein 22 (PMP22) is a tetraspan membrane protein strongly expressed in myelinating Schwann cells of the peripheral nervous system. Myriad…”
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Peripheral myelin protein 22 alters membrane architecture by Mittendorf, Kathleen F, Marinko, Justin T, Hampton, Cheri M, Ke, Zunlong, Hadziselimovic, Arina, Schlebach, Jonathan P, Law, Cheryl L, Li, Jun, Wright, Elizabeth R, Sanders, Charles R, Ohi, Melanie D

“…Peripheral myelin protein 22 (PMP22) is highly expressed in myelinating Schwann cells of the peripheral nervous system. genetic alterations cause the most…”
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Literacy-adapted, electronic family history assessment for genetics referral in primary care: patient user insights from qualitative interviews by Mittendorf, Kathleen F, Lewis, Hannah S, Duenas, Devan M, Eubanks, Donna J, Gilmore, Marian J, Goddard, Katrina A B, Joseph, Galen, Kauffman, Tia L, Kraft, Stephanie A, Lindberg, Nangel M, Reyes, Ana A, Shuster, Elizabeth, Syngal, Sapna, Ukaegbu, Chinedu, Zepp, Jamilyn M, Wilfond, Benjamin S, Porter, Kathryn M

“…Risk assessment for hereditary cancer syndromes is recommended in primary care, but family history is rarely collected in enough detail to facilitate risk…”
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Risk management actions following genetic testing in the Cancer Health Assessments Reaching Many (CHARM) Study: A prospective cohort study by Guo, Boya, Knerr, Sarah, Kauffman, Tia L., Mittendorf, Kathleen F., Keast, Erin, Gilmore, Marian J., Feigelson, Heather Spencer, Lynch, Frances L., Muessig, Kristin R., Okuyama, Sonia, Zepp, Jamilyn M., Veenstra, David L., Hsu, Li, Phipps, Amanda I., Lindström, Sara, Leo, Michael C., Goddard, Katrina A. B., Wilfond, Benjamin S., Devine, Beth, Allen, Jake, Amendola, Laura M., Anderson, Katherine P., Angelo, Frank, Arnold, Briana L., Bellcross, Cecelia, Bendelow, Tiffany, Biesecker, Barbara B., Breslin, Kristin D., Bulkley, Joanna E., Booker, Kristina F., Caruncho, Mikaella, Davis, James V., Deutsch, Sonia, Dorschner, Michael O., Duenas, Devan M., Eubanks, Donna J., Freed, Amanda S., Gilmore, Marian J., Greaney, Clay, Gruß, Inga, Guerra, Claudia, Holup, Joan, Hunter, Jessica Ezzell, Ingphakorn, Chalinya L., Jackson, Paige, Jarvik, Gail P., Jenkins, Charisma L., Joseph, Galen, Karliner, Leah S., Koomas, Alyssa H., Kraft, Stephanie A., Lee, Mi H., Lee, Robin, Lee, Sandra Soo‐Jin, Lewis, Hannah S., Liles, Elizabeth G., Lindberg, Nangel M., McMullen, Carmit K., Medina, Elizabeth, Muessig, Kristin R., Okuyama, Sonia, Peterson, C. Samuel, Paolucci, Angela R., Perez, Rosse Rodriguez, Porter, Kathryn M., Ransom, Chelese L., Reyes, Ana, Riddle, Leslie S., Robinson, Sperry, Rolf, Bradley A., Rope, Alan F., Schield, Emily, Schneider, Jennifer L., Shipman, Kelly J., Shirts, Brian H, Shuster, Elizabeth, Syngal, Sapna, Torgrimson‐Ojerio, Britta N., Ukaegbu, Chinedu, Vandermeer, Meredith L., Varga, Alexandra M., Veenstra, David L., Whitebirch, W. Chris, White, Larissa Lee

“…Background Genetic testing can identify cancer risk early, enabling prevention and early detection. We describe use of risk management interventions following…”
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Lessons learned and recommendations for data coordination in collaborative research: The CSER consortium experience by Muenzen, Kathleen D., Amendola, Laura M., Kauffman, Tia L., Mittendorf, Kathleen F., Bensen, Jeannette T., Chen, Flavia, Green, Richard, Powell, Bradford C., Kvale, Mark, Angelo, Frank, Farnan, Laura, Fullerton, Stephanie M., Robinson, Jill O., Li, Tianran, Murali, Priyanka, Lawlor, James M.J., Ou, Jeffrey, Hindorff, Lucia A., Jarvik, Gail P., Crosslin, David R.

“…Integrating data across heterogeneous research environments is a key challenge in multi-site, collaborative research projects. While it is important to allow…”
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Protecting Privacy of Pregnant and LGBTQ+ Research Participants by Clayton, Ellen Wright, Bland, Harris T, Mittendorf, Kathleen F

“…This Viewpoint summarizes existing federal regulations aimed at protecting research data, describes the challenges of enforcing these regulations, and…”
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Recommended care and care adherence following a diagnosis of Lynch syndrome: a mixed-methods study by Mittendorf, Kathleen F, Hunter, Jessica Ezzell, Schneider, Jennifer L, Shuster, Elizabeth, Rope, Alan F, Zepp, Jamilyn, Gilmore, Marian J, Muessig, Kristin R, Davis, James V, Kauffman, Tia L, Bergen, Kellene M, Wiesner, Georgia L, Acheson, Louise S, Peterson, Susan K, Syngal, Sapna, Reiss, Jacob A, Goddard, Katrina A B

“…Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome. This study assesses trends in diagnosis of LS and adherence to recommended…”
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Primary Ovarian Insufficiency and Adolescent Vaccination by Naleway, Allison L, Mittendorf, Kathleen F, Irving, Stephanie A, Henninger, Michelle L, Crane, Bradley, Smith, Ning, Daley, Matthew F, Gee, Julianne

“…Published case series have suggested a potential association between human papillomavirus (HPV) vaccination and primary ovarian insufficiency (POI). We…”
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Incidence of Adolescent Syncope and Related Injuries Following Vaccination and Routine Venipuncture by Groom, Holly C., Brooks, Neon B., Weintraub, Eric S., Slaughter, Matthew T., Mittendorf, Kathleen F., Naleway, Allison L.

“…Vaccination is associated with syncope in adolescents. However, incidence of vaccine-associated syncope and resulting injury, and how it compares to syncope…”
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The My Cancer Genome clinical trial data model and trial curation workflow by Jain, Neha, Mittendorf, Kathleen F, Holt, Marilyn, Lenoue-Newton, Michele, Maurer, Ian, Miller, Clinton, Stachowiak, Matthew, Botyrius, Michelle, Cole, James, Micheel, Christine, Levy, Mia

“…Abstract Objective As clinical trials evolve in complexity, clinical trial data models that can capture relevant trial data in meaningful, structured…”
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Utilization of electronic health record data to evaluate the association of urban environment with systemic lupus erythematosus symptoms by Song, Janet, Forrest, Noah, Gordon, Adam, Kottyan, Leah, Mittendorf, Kathleen F, Wei, Wei-Qi, Ramsey-Goldman, Rosalind, Walunas, Theresa, Kho, Abel

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Participant-guided development of bilingual genomic educational infographics for Electronic Medical Records and Genomics Phase IV study by Casillan, Aimiel, Florido, Michelle E, Galarza-Cornejo, Jamie, Bakken, Suzanne, Lynch, John A, Chung, Wendy K, Mittendorf, Kathleen F, Berner, Eta S, Connolly, John J, Weng, Chunhua, Holm, Ingrid A, Khan, Atlas, Kiryluk, Krzysztof, Limdi, Nita A, Petukhova, Lynn, Sabatello, Maya, Wynn, Julia

“…Abstract Objective Developing targeted, culturally competent educational materials is critical for participant understanding of engagement in a large genomic…”
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While the revolution will not be crystallized, biochemistry reigns supreme by Takizawa, Yoshimasa, Binshtein, Elad, Erwin, Amanda L., Pyburn, Tasia M., Mittendorf, Kathleen F., Ohi, Melanie D.

“…Single‐particle cryo‐electron microscopy (EM) is currently gaining attention for the ability to calculate structures that reach sub‐5 Å resolutions; however,…”
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Risk‐reducing surgery in unaffected individuals receiving cancer genetic testing in an integrated health care system by Knerr, Sarah, Guo, Boya, Mittendorf, Kathleen F., Feigelson, Heather Spencer, Gilmore, Marian J., Jarvik, Gail P., Kauffman, Tia L., Keast, Erin, Lynch, Frances L., Muessig, Kristin R., Okuyama, Sonia, Veenstra, David L., Zepp, Jamilyn M., Goddard, Katrina A. B., Devine, Beth

“…Background Germline genetic testing enables primary cancer prevention, including through prophylactic surgery. We examined risk‐reducing surgeries in…”
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Bicelles Rich in both Sphingolipids and Cholesterol and Their Use in Studies of Membrane Proteins by Hutchison, James M, Shih, Kuo-Chih, Scheidt, Holger A, Fantin, Sarah M, Parson, Kristine F, Pantelopulos, George A, Harrington, Haley R, Mittendorf, Kathleen F, Qian, Shuo, Stein, Richard A, Collier, Scott E, Chambers, Melissa G, Katsaras, John, Voehler, Markus W, Ruotolo, Brandon T, Huster, Daniel, McFeeters, Robert L, Straub, John E, Nieh, Mu-Ping, Sanders, Charles R

“…How the distinctive lipid composition of mammalian plasma membranes impacts membrane protein structure is largely unexplored, partly because of the dearth of…”
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Cost-effectiveness frameworks for comparing genome and exome sequencing versus conventional diagnostic pathways: A scoping review and recommended methods by Ferket, Bart S., Baldwin, Zach, Murali, Priyanka, Pai, Akila, Mittendorf, Kathleen F., Russell, Heidi V., Chen, Flavia, Lynch, Frances L., Lich, Kristen Hassmiller, Hindorff, Lucia A., Savich, Renate, Slavotinek, Anne, Smith, Hadley Stevens, Gelb, Bruce D., Veenstra, David L.

“…Methodological challenges have limited economic evaluations of genome sequencing (GS) and exome sequencing (ES). Our objective was to develop conceptual…”
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