Search Results - "Mittenbühler, K."

Lipopeptide adjuvants in combination treatment by Bessler, Wolfgang G, Mittenbühler, K, Esche, U.v.d, Huber, M

“…Synthetic lipopeptides derived from the N-terminus of bacterial lipoprotein constitute potent immunoadjuvants for parenteral and mucosal immunization. When…”
Get full text

Modulation of the Th1/Th2 bias by an immunoglobulin histamine complex in the ovalbumin allergy mouse model by Ayoub, M., Lallouette, P., Sütterlin, B.W., Bessler, W.G., Huber, M., Mittenbühler, K.

“…Vaccination with the antiallergic drug Histaglobin is used to treat a broad range of human allergic diseases including bronchial asthma, allergic rhinitis, and…”
Get full text

Purification and characterization of acid trehalase from the yeast suc2 mutant by Mittenbühler, K, Holzer, H

“…Acid trehalase was purified from the yeast suc2 deletion mutant. After hydrophobic interaction chromatography, the enzyme could be purified to a single band or…”
Get full text

Lipopeptide adjuvants: monitoring and comparison of P3CSK4- and LPS-induced gene transcription by MÜLLER, M. R, WIESMÜLLER, K.-H, JUNG, G, LOOP, T, HUMAR, M, PFANNES, S. D. C, BESSLER, W. G, MITTENBÜHLER, K

“…Bacteria-derived synthetic lipoproteins constitute potent macrophage activators in vivo and are effective stimuli, enhancing the immune response especially…”
Get full text

Generation of antibodies directed against the low-immunogenic peptide-toxins microcystin-LR/RR and nodularin by Baier, W, Loleit, M, Fischer, B, Jung, G, Neumann, U, Weiß, M, Weckesser, J, Hoffmann, P, Bessler, W.G, Mittenbühler, K

“…The preparation of antibodies against the liver toxin microcystin, as described here, is of major importance for its detection and purification in food and…”
Get full text

Lipopeptides: adjuvanticity in conventional and genetic immunization by Mittenbühler, K., v.d. Esche, U., Heinevetter, L., Bessler, W.G., Huber, M.

“…Synthetic lipopeptides derived from the bacterial cell wall component lipoprotein activate B-lymphocytes and macrophages/monocytes in vitro. In vivo they…”
Get full text

Lipopeptide adjuvants: generation of lactate dehydrogenase isoenzyme-specific antibodies for immunochemical diagnosis by Gampp, T M, Moser, I, Jobst, G, Urban, G, Ayoub, M, Pfannes, S D, Hoffmann, P, Bessler, W G, Mittenbühler, K

“…Lactate dehydrogenase catalyzes the final step in glycolysis, the interconversion of pyruvate and lactate. The tetrameric enzyme is composed of one or two…”
Get more information

Immunostimulation by bacterial components: I. Activation of macrophages and enhancement of genetic immunization by the lipopeptide P3CSK4 by ESCHE, U. V. D, AYOUB, M, HOFFMANN, P, BESSLER, W. G, MITTENBÜHLER, K, PFANNES, S. D. C, MÜLLER, M. R, HUBER, M, WIESMÜLLER, K.-H, LOOP, T, HUMAR, M, FISCHBACH, K.-F, STRÜNKELNBERG, M

“…Synthetic lipopeptides derived from the N-terminus of bacterial lipoprotein constitute potent macrophage activators and polyclonal B-lymphocyte stimulators…”
Get full text

Immunostimulatory activity of the bacterial extract OM-8 by Huber, M, Ayoub, M, Pfannes, S D, Mittenbühler, K, Weis, K, Bessler, W G, Baier, W

“…The bacterial extract OM-89 used for the prevention and treatment of recurrent urinary tract infections constitutes an effective immunostimulant in vitro and…”
Get more information

Integrated Sample Preparation, Reaction, and Detection on a High-Frequency Centrifugal Microfluidic Platform by Steigert, J., Grumann, M., Brenner, T., Mittenbühler, K., Nann, T., Rühe, J., Moser, I., Haeberle, S., Riegger, L., Riegler, J., Bessler, W., Zengerle, R., Ducrée, J.

“…We extend the toolbox of lab procedures in life sciences by development of centrifugal microfluidics for high-level process integration. This is accomplished…”
Get full text

Bacterial cell wall components as immunomodulators—I. lipopeptides as adjuvants for parenteral and oral immunization by Bessler, W.G., Heinevetter, L., WiesmÜller, K.-H., Jung, G., Baier, W., Huber, M., Lorenz, A.R., Esche, U.V.D., Mittenbühler, K., Hoffmann, P.

“…We investigated the immunostimulatory properties of synthetically prepared lipopeptides derived from the cell wall of Gram negative bacteria. These compounds…”
Get full text

Characterization of different forms of yeast acid trehalase in the secretory pathway by Mittenbuhler, K, Holzer, H

“…The biosynthesis and processing of the vacuolar (lysosomal) acid trehalase (molecular mass about 220 kDa) was followed in vivo using mutants conditionally…”
Get full text

Drug specific antibodies: T-cell epitope-lipopeptide conjugates are potent adjuvants for small antigens in vivo and in vitro by Mittenbühler, Klaus, Loleit, Manuel, Baier, Wiltrud, Fischer, Bianca, Sedelmeier, Eva, Jung, Günther, Winkelmann, Günther, Jacobi, Clemens, Weckesser, Jürgen, Erhard, Michael H., Hofmann, Andrea, Bessler, Wolfgang, Hoffmann, Petra

“…To generate conventional or monoclonal antibodies for the serological detection of drugs, antibiotics, toxins and other low molecular mass substances, a…”
Get full text

Induction of an epitope-specific humoral immune response by lipopeptide–hapten conjugates: enhancement of the anti-melittin response by a synthetic T helper (T h)-cell epitope by Hoffmann, Petra, Loleit, Manuel, Mittenbühler, Klaus, Beck, Werner, Wiesmüller, Karl-Heinz, Jung, Günther, Bessler, Wolfgang G

“…Lipopeptides of bacterial origin constitute potent immunoadjuvants when combined with antigens. After the immunization with lipopeptides covalently coupled to…”
Get full text

Parallelization of chip-based fluorescence immuno-assays with quantum-dot labeled beads by Grumann, M., Riegger, L., Pastewka, L., Brenner, T., Zengerle, R., Ducree, J., Nann, T., Riegler, J., Ehlert, O., Mittenbuhler, K., Urban, G.

“…This paper presents an optical concept for the read-out of a parallel, bead-based fluorescence immunoassay conducted on a lab-on-a-disk platform. The reusable…”
Get full text

Immunostimulation by the synthetic lipopeptide P3CSK4: TLR4‐independent activation of the ERK1/2 signal transduction pathway in macrophages by Müller, Markus R., Pfannes, Silke D. C., Ayoub, Mohamed, Hoffmann, Petra, Bessler, Wolfgang G., Mittenbühler, Klaus

“…Summary Synthetic lipopeptides based on bacterial lipoprotein are efficient activators for monocytes/macrophages inducing the release of interleukin (IL)‐1,…”
Get full text

Lipopeptide adjuvants in combination treatment: Combination immunotherapy by BESSLER, Wolfgang G, MITTENBÜHLER, K, ESCHE, U. V. D, HUBER, M

Get full text

Lipopeptide adjuvants: monitoring and comparison of P 3CSK 4- and LPS-induced gene transcription by Müller, M.R, Wiesmüller, K.-H, Jung, G, Loop, T, Humar, M, Pfannes, S.D.C, Bessler, W.G, Mittenbühler, K

“…Bacteria-derived synthetic lipoproteins constitute potent macrophage activators in vivo and are effective stimuli, enhancing the immune response especially…”
Get full text

The anti-allergic drug histaglobin inhibits NF-kappaB nuclear translocation and down-regulates proinflammatory cytokines by Ayoub, M, Mittenbühler, K, Sütterlin, B W, Bessler, W G

“…The transcription factor NF-kappaB is the central regulator for the expression of various genes involved in inflammation, infection and immune response…”
Get full text

Immunostimulation by bacterial components: I. Activation of macrophages and enhancement of genetic immunization by the lipopeptide P 3CSK 4 by Esche, U.v.d, Ayoub, M, Pfannes, S.D.C, Müller, M.R, Huber, M, Wiesmüller, K.-H, Loop, T, Humar, M, Fischbach, K.-F, Strünkelnberg, M, Hoffmann, P, Bessler, W.G, Mittenbühler, K

“…Synthetic lipopeptides derived from the N-terminus of bacterial lipoprotein constitute potent macrophage activators and polyclonal B-lymphocyte stimulators…”
Get full text