Search Results - "Mittelstaedt, Roberta A"

Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay by Li, Yan, Chen, David H., Yan, Jian, Chen, Ying, Mittelstaedt, Roberta A., Zhang, Yongbin, Biris, Alexandru S., Heflich, Robert H., Chen, Tao

“…► Genotoxicity of AgNPs was assessed using the Ames test and micronucleus assay. ► The AgNPs are negative in the Ames test and positive in the micronucleus…”
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The Genotoxicity of Acrylamide and Glycidamide in Big Blue Rats by Mei, Nan, McDaniel, Lea P., Dobrovolsky, Vasily N., Guo, Xiaoqing, Shaddock, Joseph G., Mittelstaedt, Roberta A., Azuma, Mizuo, Shelton, Sharon D., McGarrity, Lynda J., Doerge, Daniel R., Heflich, Robert H.

“…Acrylamide (AA), a mutagen and rodent carcinogen, recently has been detected in fried and baked starchy foods, a finding that has prompted renewed interest in…”
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Comparative analysis of micronuclei and DNA damage induced by Ochratoxin A in two mammalian cell lines by Ali, Rahat, Mittelstaedt, Roberta A., Shaddock, Joseph G., Ding, Wei, Bhalli, Javed A., Khan, Qaiser M., Heflich, Robert H.

“…The fungal toxin, Ochratoxin A (OTA), is a common contaminant in human food and animal feed. The present study evaluated micronucleus (MN) induction by OTA in…”
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In vivo genotoxicity of furan in F344 rats at cancer bioassay doses by Ding, Wei, Petibone, Dayton M., Latendresse, John R., Pearce, Mason G., Muskhelishvili, Levan, White, Gene A., Chang, Ching-Wei, Mittelstaedt, Roberta A., Shaddock, Joseph G., McDaniel, Lea P., Doerge, Daniel R., Morris, Suzanne M., Bishop, Michelle E., Manjanatha, Mugimane G., Aidoo, Anane, Heflich, Robert H.

“…Furan, a potent rodent liver carcinogen, is found in many cooked food items and thus represents a human cancer risk. Mechanisms for furan carcinogenicity were…”
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Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adult gpt-delta transgenic mice by Cao, Xuefei, Mittelstaedt, Roberta A., Pearce, Mason G., Allen, Bruce C., Soeteman-Hernández, Lya G., Johnson, George E., Bigger, C. Anita H., Heflich, Robert H.

“…The assumption that mutagens have linear dose–responses recently has been challenged. In particular, ethyl methanesulfonate (EMS), a DNA‐reactive mutagen and…”
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Using ΦX174 DNA as an exogenous reference for measuring mitochondrial DNA copy number by Meagan B. Myers, Roberta A. Mittelstaedt, Robert H. Heflich

“…Quantitative real-time PCR has become a popular method to analyze and quantify changes in the copy number of mitochondrial DNA (mtDNA), and nuclear DNA (nDNA)…”
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Evaluation of Macaca mulatta as a model for genotoxicity studies by Dobrovolsky, Vasily N., Shaddock, Joseph G., Mittelstaedt, Roberta A., Manjanatha, Mugimane G., Miura, Daishiro, Uchikawa, Makoto, Mattison, Donald R., Morris, Suzanne M.

“…We have investigated the use of peripheral blood from the nonhuman primate (NHP) rhesus monkey ( Macaca mulatta) as a model system for mutation detection. The…”
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Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations by Wang, Yiying, Le, Yuan, Harris, Kelly L., Chen, Ying, Li, Xilin, Faske, Jennifer, Wynne, Rebecca A., Mittelstaedt, Roberta A., Cao, Xuefei, Miranda-Colon, Jaime, Elkins, Lana, Muskhelishvili, Levan, Davis, Kelly, Mei, Nan, Sun, Wei, Robison, Timothy W., Heflich, Robert H., Parsons, Barbara L.

“…The human in vitro organotypic air-liquid-interface (ALI) airway tissue model is structurally and functionally similar to the human large airway epithelium…”
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Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity by Mittelstaedt, Roberta A., Dad, Azra, Pearce, Mason G., Heflich, Robert H., Cao, Xuefei

“…In order to investigate the possibility that treatment age affects the genotoxic response to ethyl methane sulfonate (EMS) exposure, we dosed gpt‐delta…”
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Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays by Li, Xilin, Le, Yuan, Seo, Ji-Eun, Guo, Xiaoqing, Li, Yuxi, Chen, Si, Mittelstaedt, Roberta A., Moore, Nyosha, Guerrero, Sharon, Sims, Audrey, King, Sruthi T., Atrakchi, Aisar H., McGovern, Timothy J., Davis-Bruno, Karen L., Keire, David A., Elespuru, Rosalie K., Heflich, Robert H., Mei, Nan

“…Propranolol is a widely used β-blocker that can generate a nitrosated derivative, N-nitroso propranolol (NNP). NNP has been reported to be negative in the…”
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Genotoxicity of malachite green and leucomalachite green in female Big Blue B6C3F1 mice by MITTELSTAEDT, Roberta A, NAN MEI, HEFLICH, Robert H, WEBB, Peggy J, SHADDOCK, Joseph G, DOBROVOLSKY, Vasily N, MCGARRITY, Lynda J, MORRIS, Suzanne M, TAO CHEN, BELAND, Frederick A, GREENLEES, Kevin J

“…Malachite green, a triphenylmethane dye used in aquaculture as an antifungal agent, is rapidly reduced in vivo to leucomalachite green. Previous studies in…”
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The genetic toxicology of methylphenidate hydrochloride in non-human primates by Morris, Suzanne M., Dobrovolsky, Vasily N., Shaddock, Joseph G., Mittelstaedt, Roberta A., Bishop, Michelle E., Manjanatha, Mugimane G., Shelton, Sharon D., Doerge, Daniel R., Twaddle, Nathan C., Chen, James J., Lin, Chien-Ju, Paule, Merle G., Slikker, William, Hotchkiss, Charlotte E., Petibone, Dayton, Tucker, James D., Mattison, Donald R.

“…The studies presented in this work were designed to evaluate the genetic toxicity of methylphenidate hydrochloride (MPH) in non-human primates (NHP) using a…”
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Optimizing the detection of N-nitrosamine mutagenicity in the Ames test by Heflich, Robert H., Bishop, Michelle E., Mittelstaedt, Roberta A., Yan, Jian, Guerrero, Sharon K., Sims, Audrey M., Mitchell, Kamela, Moore, Nyosha, Li, Xilin, Mei, Nan, Elespuru, Rosalie K., King, Sruthi T., Keire, David A., Kruhlak, Naomi L., Dorsam, Robert T., Raw, Andre S., Davis Bruno, Karen L., McGovern, Timothy J., Atrakchi, Aisar H.

“…Accurately determining the mutagenicity of small-molecule N-nitrosamine drug impurities and nitrosamine drug substance-related impurities (NDSRIs) is critical…”
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Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing by Wang, Yiying, Mittelstaedt, Roberta A., Wynne, Rebecca, Chen, Ying, Cao, Xuefei, Muskhelishvili, Levan, Davis, Kelly, Robison, Timothy W., Sun, Wei, Schmidt, Elizabeth K., Smith, Thomas H., Norgaard, Zachary K., Valentine, Charles C., Yaplee, Jeffry, Williams, Lindsey N., Salk, Jesse J., Heflich, Robert H.

“…The organotypic human air‐liquid‐interface (ALI) airway tissue model has been used as an in vitro cell culture system for evaluating the toxicity of inhaled…”
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Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage by Hu, Shu-Chieh, Bryant, Matthew S, Sepehr, Estatira, Kang, Hyun-Ki, Trbojevich, Raul, Lagaud, Guy, Mehta, Darshan, Ding, Wei, Mittelstaedt, Roberta A, Pearce, Mason G, Bishop, Michelle E, Davis, Kelly J, Lewis, Sherry M, Chemerynski, Susan, Yee, Steven B, Coraggio, Melis, Rosenfeldt, Hans, Yeager, R Philip, Howard, Paul C, Tang, Yunan

“…Abstract The tobacco-specific nitrosamine NNK [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone] is found in tobacco products and tobacco smoke. NNK is a potent…”
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Confirmation of Pig-a mutation in flow cytometry-identified CD48-deficient T-lymphocytes from F344 rats by Revollo, Javier, Pearce, Mason G, Petibone, Dayton M, Mittelstaedt, Roberta A, Dobrovolsky, Vasily N

“…The Pig-a assay is used for monitoring somatic cell mutation in laboratory animals and humans. The assay detects haematopoietic cells deficient in…”
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Factors affecting the in vitro micronucleus assay for evaluation of nanomaterials by Li, Yan, Doak, Shareen H, Yan, Jian, Chen, David H, Zhou, Min, Mittelstaedt, Roberta A, Chen, Ying, Li, Chun, Chen, Tao

“…A number of in vitro methodologies have been used to assess the genotoxicity of different nanomaterials, including titanium dioxide nanoparticles (TiO NPs) and…”
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CD59‐deficient bone marrow erythroid cells from rats treated with procarbazine and propyl‐nitrosourea have mutations in the Pig‐a gene by Revollo, Javier R., Dad, Azra, Pearce, Mason G., Mittelstaedt, Roberta A., Casildo, Andrea, Lapidus, Rena G., Robison, Timothy W., Dobrovolsky, Vasily N.

“…Procarbazine (PCZ) and N‐propyl‐N‐nitrosourea (PNU) are rodent mutagens and carcinogens. Both induce GPI‐anchored marker‐deficient mutant‐phenotype red blood…”
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Pig-a mutations in bone marrow erythroblasts of rats treated with 7,12-dimethyl-benz[a]anthracene by Revollo, Javier R., Dad, Azra, Pearce, Mason G., Mittelstaedt, Roberta A., Robison, Timothy W., Dobrovolsky, Vasily N.

“…•Rats treated with DMBA show increased frequencies of CD59-deficient BMEs.•CD59-deficient BMEs from DMBA-treated rats have mutations in the Pig-a gene.•The…”
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Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes by Dobrovolsky, Vasily N, Shaddock, Joseph G, Mittelstaedt, Roberta A, Miura, Daishiro, Heflich, Robert H

“…Assays for in vivo mutation are used to identify genotoxic hazards and phenotypes prone to genomic instability and cancer. The hypoxanthine guanine…”
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