Search Results - "Mitsumori, Susumu"

Direct Asymmetric anti-Mannich-Type Reactions Catalyzed by a Designed Amino Acid by MITSUMORI, Susumu, ZHANG, Haile, HA-YEON CHEONG, Paul, HOUK, K. N., TANAKA, Fujie, BARBAS, Carlos F.

“…The development of catalysts for Mannich-type reactions that afford anti-products with excellent diastereo- and enantioselectivities under mild conditions and…”
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Recent progress in work on PGD2 antagonists for drugs targeting allergic diseases by Mitsumori, Susumu

“…Prostaglandin (PG) D(2), the major cyclooxygenase metabolite generated from immunologically stimulated mast cells, is thought to contribute to the pathogenesis…”
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Catalysis of 3-Pyrrolidinecarboxylic Acid and Related Pyrrolidine Derivatives in Enantioselective anti-Mannich-Type Reactions:  Importance of the 3-Acid Group on Pyrrolidine for Stereocontrol by Zhang, Haile, Mitsumori, Susumu, Utsumi, Naoto, Imai, Masanori, Garcia-Delgado, Noemi, Mifsud, Maria, Albertshofer, Klaus, Cheong, Paul Ha-Yeon, Houk, K. N, Tanaka, Fujie, Barbas, Carlos F

“…The development of enantioselective anti-selective Mannich-type reactions of aldehydes and ketones with imines catalyzed by 3-pyrrolidinecarboxylic acid and…”
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Dihydroxyacetone Variants in the Organocatalytic Construction of Carbohydrates:  Mimicking Tagatose and Fuculose Aldolases by Suri, Jeff T, Mitsumori, Susumu, Albertshofer, Klaus, Tanaka, Fujie, Barbas, Carlos F

“…Dihydroxyacetone variants have been explored as donors in organocatalytic aldol reactions with various aldehyde and ketone acceptors. The protected form of…”
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Synthesis and Biological Activity of Various Derivatives of a Novel Class of Potent, Selective, and Orally Active Prostaglandin D2 Receptor Antagonists. 2. 6,6-Dimethylbicyclo[3.1.1]heptane Derivatives by Mitsumori, Susumu, Tsuri, Tatsuo, Honma, Tsunetoshi, Hiramatsu, Yoshiharu, Okada, Toshihiko, Hashizume, Hiroshi, Kida, Shiro, Inagaki, Masanao, Arimura, Akinori, Yasui, Kiyoshi, Asanuma, Fujio, Kishino, Junji, Ohtani, Mitsuaki

“…In an earlier paper, we reported that novel prostaglandin D2 (PGD2) receptor antagonists having the bicyclo[2.2.1]heptane ring system as a prostaglandin…”
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Total Synthesis of Terprenin, a Highly Potent and Novel Immunoglobulin E Antibody Suppressant by Kawada, Kenji, Arimura, Akinori, Tsuri, Tatsuo, Fuji, Masahiro, Komurasaki, Tadafumi, Yonezawa, Shuji, Kugimiya, Akira, Haga, Nobuhiro, Mitsumori, Susumu, Inagaki, Masanao, Nakatani, Takuji, Tamura, Yoshinori, Takechi, Shozo, Taishi, Teruhiko, Kishino, Junji, Ohtani, Mitsuaki

“…Regioselective halogenations and Suzuki reactions ensure proper linkage of the aromatic rings in two total syntheses of terprenin (1). Both routes make it…”
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Discovery of S-777469: An orally available CB2 agonist as an antipruritic agent by Odan, Masahide, Ishizuka, Natsuki, Hiramatsu, Yoshiharu, Inagaki, Masanao, Hashizume, Hiroshi, Fujii, Yasuhiko, Mitsumori, Susumu, Morioka, Yasuhide, Soga, Masahiko, Deguchi, Masashi, Yasui, Kiyoshi, Arimura, Akinori

“…The discovery of novel CB2 ligands based on the 3-carbamoyl-2-pyridone derivatives by adjusting the size of side chain at 1-, 5- and 6-position is reported…”
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Discovery of S-444823, a potent CB1/CB2 dual agonist as an antipruritic agent by Odan, Masahide, Ishizuka, Natsuki, Hiramatsu, Yoshiharu, Inagaki, Masanao, Hashizume, Hiroshi, Fujii, Yasuhiko, Mitsumori, Susumu, Morioka, Yasuhide, Soga, Masahiko, Deguchi, Masashi, Yasui, Kiyoshi, Arimura, Akinori

“…The optimization of a series of 3-carbamoyl 2-pyridone derivatives as CB agonists is reported. These efforts resulted in the discovery of…”
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CB 1/2 dual agonists with 3-carbamoyl 2-pyridone derivatives as antipruritics: Reduction of CNS side effects by introducing polar functional groups by Odan, Masahide, Ishizuka, Natsuki, Hiramatsu, Yoshiharu, Inagaki, Masanao, Hashizume, Hiroshi, Fujii, Yasuhiko, Mitsumori, Susumu, Morioka, Yasuhide, Soga, Masahiko, Deguchi, Masashi, Yasui, Kiyoshi, Arimura, Akinori

“…Our lead compound 1 showed high affinity for both CB1 and CB2 receptors, suggesting the possibility of inducing psychoactive side effects through the CB1…”
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Practical Diastereoselective Synthesis and Scale-up Study of (+)-2-((1 R ,2 R ,3 R ,5 S )-2-Amino-6,6-dimethylbicyclo[3.1.1]hept-3-yl)ethanol: A Key Intermediate of the Novel Prostaglandin D 2 Receptor Antagonist S-5751 by Hida, Takemasa, Mitsumori, Susumu, Honma, Tsunetoshi, Hiramatsu, Yoshiharu, Hashizume, Hiroshi, Okada, Tetsuo, Kakinuma, Makoto, Kawata, Kyozo, Oda, Katsuo, Hasegawa, Aiko, Masui, Toshiaki, Nogusa, Hideo

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Practical Diastereoselective Synthesis and Scale-up Study of (+)-2-((1R,2R,3R,5S)-2-Amino-6,6-dimethylbicyclo[3.1.1]hept-3-yl)ethanol: A Key Intermediate of the Novel Prostaglandin D2 Receptor Antagonist S-5751 by Hida, Takemasa, Mitsumori, Susumu, Honma, Tsunetoshi, Hiramatsu, Yoshiharu, Hashizume, Hiroshi, Okada, Tetsuo, Kakinuma, Makoto, Kawata, Kyozo, Oda, Katsuo, Hasegawa, Aiko, Masui, Toshiaki, Nogusa, Hideo

“…A new synthetic process was developed for (+)-2-((1R,2R,3R,5S)-2-amino-6,6-dimethylbicyclo[3.1.1]hept-3-yl)ethanol, a key intermediate of S-5751…”
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Synthesis and Biological Activity of Various Derivatives of a Novel Class of Potent, Selective, and Orally Active Prostaglandin D 2 Receptor Antagonists. 2. 6,6-Dimethylbicyclo[3.1.1]heptane Derivatives by Mitsumori, Susumu, Tsuri, Tatsuo, Honma, Tsunetoshi, Hiramatsu, Yoshiharu, Okada, Toshihiko, Hashizume, Hiroshi, Kida, Shiro, Inagaki, Masanao, Arimura, Akinori, Yasui, Kiyoshi, Asanuma, Fujio, Kishino, Junji, Ohtani, Mitsuaki

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Synthesis and Biological Activity of Various Derivatives of a Novel Class of Potent, Selective, and Orally Active Prostaglandin D2 Receptor Antagonists. 1. Bicyclo[2.2.1]heptane Derivatives by Mitsumori, Susumu, Tsuri, Tatsuo, Honma, Tsunetoshi, Hiramatsu, Yoshiharu, Okada, Toshihiko, Hashizume, Hiroshi, Inagaki, Masanao, Arimura, Akinori, Yasui, Kiyoshi, Asanuma, Fujio, Kishino, Junji, Ohtani, Mitsuaki

“…Novel prostaglandin D2 (PGD2) receptor antagonists were synthesized as a potential new class of antiallergic agents having a bicyclo[2.2.1]heptane ring system…”
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Synthesis and Biological Activity of Various Derivatives of a Novel Class of Potent, Selective, and Orally Active Prostaglandin D 2 Receptor Antagonists. 1. Bicyclo[2.2.1]heptane Derivatives by Mitsumori, Susumu, Tsuri, Tatsuo, Honma, Tsunetoshi, Hiramatsu, Yoshiharu, Okada, Toshihiko, Hashizume, Hiroshi, Inagaki, Masanao, Arimura, Akinori, Yasui, Kiyoshi, Asanuma, Fujio, Kishino, Junji, Ohtani, Mitsuaki

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Direct Asymmetric a nti-Mannich-Type Reactions Catalyzed by a Designed Amino Acid by Mitsumori, Susumu, Zhang, Haile, Ha-Yeon Cheong, Paul, Houk, K. N, Tanaka, Fujie, Barbas, Carlos F

“…The development of catalysts for Mannich-type reactions that afford anti-products with excellent diastereo- and enantioselectivities under mild conditions and…”
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Total Synthesis of Terprenin, a Novel Immunosuppressive p-Terphenyl Derivative by Yonezawa, Shuji, Komurasaki, Tadafumi, Kawada, Kenji, Tsuri, Tatsuo, Fuji, Masahiro, Kugimiya, Akira, Haga, Nobuhiro, Mitsumori, Susumu, Inagaki, Masanao, Nakatani, Takuji, Tamura, Yoshinori, Takechi, Shozo, Taishi, Teruhiko, Ohtani, Mitsuaki

“…We achieved a total synthesis of terprenin, a novel potent immunoglobulin E antibody suppressant which was obtained from the fermentation broth of Aspergillus…”
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Bicyclo[2.2.1]heptane and 6,6-Dimethylbicyclo[3.1.1]heptane Derivatives:  Orally Active, Potent, and Selective Prostaglandin D 2 Receptor Antagonists by Tsuri, Tatsuo, Honma, Tsunetoshi, Hiramatsu, Yoshiharu, Okada, Toshihiko, Hashizume, Hiroshi, Mitsumori, Susumu, Inagaki, Masanao, Arimura, Akinori, Yasui, Kiyoshi, Asanuma, Fujio, Kishino, Junji, Ohtani, Mitsuaki

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Bicyclo[2.2.1]heptane and 6,6-Dimethylbicyclo[3.1.1]heptane Derivatives:  Orally Active, Potent, and Selective Prostaglandin D2 Receptor Antagonists by Tsuri, Tatsuo, Honma, Tsunetoshi, Hiramatsu, Yoshiharu, Okada, Toshihiko, Hashizume, Hiroshi, Mitsumori, Susumu, Inagaki, Masanao, Arimura, Akinori, Yasui, Kiyoshi, Asanuma, Fujio, Kishino, Junji, Ohtani, Mitsuaki

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Totalsynthese von Terprenin, einem hochwirksamen Immunglobulin‐E‐Suppressivum by Kawada, Kenji, Arimura, Akinori, Tsuri, Tatsuo, Fuji, Masahiro, Komurasaki, Tadafumi, Yonezawa, Shuji, Kugimiya, Akira, Haga, Nobuhiro, Mitsumori, Susumu, Inagaki, Masanao, Nakatani, Takuji, Tamura, Yoshinori, Takechi, Shozo, Taishi, Teruhiko, Kishino, Junji, Ohtani, Mitsuaki

“…Regioselektive Halogenierungen und Suzuki‐Reaktionen ermöglichen die richtige Verknüpfung der aromatischen Ringe in zwei Totalsynthesen von Terprenin 1. Durch…”
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Totalsynthese von Terprenin, einem hochwirksamen Immunglobulin-E-Suppressivum by Kawada, Kenji, Arimura, Akinori, Tsuri, Tatsuo, Fuji, Masahiro, Komurasaki, Tadafumi, Yonezawa, Shuji, Kugimiya, Akira, Haga, Nobuhiro, Mitsumori, Susumu, Inagaki, Masanao, Nakatani, Takuji, Tamura, Yoshinori, Takechi, Shozo, Taishi, Teruhiko, Kishino, Junji, Ohtani, Mitsuaki

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