Search Results - "Mitsuma, Norimasa"

The ciliopathies: an emerging class of human genetic disorders by Badano, Jose L, Mitsuma, Norimasa, Beales, Phil L, Katsanis, Nicholas

“…Cilia and flagella are ancient, evolutionarily conserved organelles that project from cell surfaces to perform diverse biological roles, including whole-cell…”
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Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia by Mizuno, Tetsuya, Kurotani, Tohru, Komatsu, Yukio, Kawanokuchi, Jun, Kato, Hideki, Mitsuma, Norimasa, Suzumura, Akio

“…The phosphodiesterase inhibitor, ibudilast, has many effects on lymphocytes, endothelial cells, and glial cells. We examined the neuroprotective role of…”
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Interferon-γ induces microglial-activation-induced cell death: A hypothetical mechanism of relapse and remission in multiple sclerosis by Takeuchi, Hideyuki, Wang, Jinyan, Kawanokuchi, Jun, Mitsuma, Norimasa, Mizuno, Tetsuya, Suzumura, Akio

“…Relapse and remission are characteristics of multiple sclerosis (MS). The underlying mechanisms, however, remain uncertain. Interferon-γ (IFN-γ) disturbs the…”
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Loss of Bardet-Biedl syndrome proteins causes defects in peripheral sensory innervation and function by Tan, Perciliz L, Barr, Travis, Inglis, Peter N, Mitsuma, Norimasa, Huang, Susan M, Garcia-Gonzalez, Miguel A, Bradley, Brian A, Coforio, Stephanie, Albrecht, Phillip J, Watnick, Terry, Germino, Gregory G, Beales, Philip L, Caterina, Michael J, Leroux, Michel R, Rice, Frank L, Katsanis, Nicholas

“…Reception and interpretation of environmental stimuli is critical for the survival of all organisms. Here, we show that the ablation of BBS1 and BBS4, two…”
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Aggregatibacter segnis endocarditis mimicking antineutrophil cytoplasmic antibody-associated vasculitis presenting with cerebral hemorrhage: a case report by Hirunagi, Tomoki, Kawanishi, Hiroshi, Mitsuma, Norimasa, Goto, Yoji, Mano, Kazuo

“…A 56-year-old man who underwent a tooth extraction in the previous year presented with weakness of the right upper extremity. Brain CT and MRI scans showed…”
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Pain-related Differential Expression of NGF, GDNF, IL-6, and Their Receptors in Human Vasculitic Neuropathies by YAMAMOTO, Masahiko, ITO, Yasuhiro, MITSUMA, Norimasa, HATTORI, Naoki, SOBUE, Gen

“…Objective Pain-related differential expressions of nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF) and interleukin-6 (IL-6), and…”
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Effects of interferon-β on microglial functions as inflammatory and antigen presenting cells in the central nervous system by Kawanokuchi, Jun, Mizuno, Tetsuya, Kato, Hideki, Mitsuma, Norimasa, Suzumura, Akio

“…Interferon-β (IFNβ) reduces exacerbations of the relapsing-remitting form of multiple sclerosis (MS), but the exact mechanisms by which it exerts its…”
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Morphological Purkinje cell changes in spinocerebellar ataxia type 6 by QING YANG, HASHIZUME, Y, YOSHIDA, M, YIN WANG, GOTO, Y, MITSUMA, N, ISHIKAWA, K, MIZUSAWA, H

“…Spinocerebellar ataxia type 6 (SCA6) was recently identified as a form of autosomal dominant spinocerebellar ataxia associated with a small CAG repeat…”
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Parallel expression of neurotrophic factors and their receptors in chronic inflammatory demyelinating polyneuropathy by Yamamoto, Masahiko, Ito, Yasuhiro, Mitsuma, Norimasa, Li, Mei, Hattori, Naoki, Sobue, Gen

“…The mRNA levels of nerve growth factor (NGF), glial cell line–derived neurotrophic factor (GDNF), ciliary neurotrophic factor (CNTF), leukemia inhibitory…”
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Preserved phosphorylation of RET receptor protein in spinal motor neurons of patients with amyotrophic lateral sclerosis: an immunohistochemical study by a phosphorylation-specific antibody at tyrosine 1062 by Yamamoto, Masahiko, Li, Mei, Mitsuma, Norimasa, Ito, Shinji, Kato, Masashi, Takahashi, Masahide, Sobue, Gen

“…Ret oncoprotein is a functional receptor for the glial cell line-derived neurotrophic factor (GDNF) family and it is expressed in motor neurons, playing an…”
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In vivo gene electroporation of glial cell line-derived neurotrophic factor (GDNF) into skeletal muscle of SOD1 mutant mice by YAMAMOTO, Masahiko, KOBAYASHI, Yasushi, MEI LI, NIWA, Hisayoshi, MITSUMA, Norimasa, ITO, Yasuhiro, MURAMATSU, Tatsuo, SOBUE, Gen

“…Motor neurons degenerate with intracellular vacuolar change and eventually disappear in spinal cords of SOD1 mutant mice, resembling human amyotrophic lateral…”
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Expression of mRNAs for ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and their receptors (CNTFRα, LIFRβ, IL-6Rα, and gp130) in human peripheral neuropathies by ITO, Yasuhiro, YAMAMOTO, Masahiko, MITSUMA, Norimasa, MEI LI, HATTORI, Naoki, SOBUE, Gen

“…The mRNA levels of neuropoietic cytokines, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and interleukin-6 (IL-6), and their receptor…”
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Pathology-related differential expression regulation of NGF, GDNF, CNTF, and IL-6 mRNAs in human vasculitic neuropathy by Yamamoto, Masahiko, Ito, Yasuhiro, Mitsuma, Norimasa, Li, Mei, Hattori, Naoki, Sobue, Gen

“…The mRNA levels of nerve growth factor (NGF), glial cell line–derived neurotrophic factor (GDNF), ciliary neurotrophic factor (CNTF), and interleukin‐6 (IL‐6)…”
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Expression of GDNF receptor (RET and GDNFR-α) mRNAs in the spinal cord of patients with amyotrophic lateral sclerosis by Mitsuma, Norimasa, Yamamoto, Masahiko, Li, Mei, Ito, Yasuhiro, Mitsuma, Terunori, Mutoh, Tatsuro, Takahashi, Masahide, Sobue, Gen

“…The mRNA levels of RET and GDNFR-α were studied in the spinal cord of patients with amyotrophic lateral sclerosis (ALS) by reverse transcription followed by…”
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Expression of GDNF and GDNFR-α mRNAs in muscles of patients with motor neuron diseases by YAMAMOTO, M, MITSUMA, N, INUKAI, A, ITO, Y, MEI LI, MITSUMA, T, SOBUE, G

“…The mRNA expression levels of GDNF, GDNFR-alpha and RET were examined in the muscles of amyotrophic lateral screlosis (ALS) and X-linked spinal and bulbar…”
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Two Novel Genes, Human neugrin and Mouse m-neugrin, Are Upregulated with Neuronal Differentiation in Neuroblastoma Cells by Ishigaki, Shinsuke, Niwa, Jun-ichi, Yoshihara, Tsuyoshi, Mitsuma, Norimasa, Doyu, Manabu, Sobue, Gen

“…We herein report two new genes, human neugrin and mouse homologue m-neugrin, found by screening the cDNA library for the human spinal cord. The neugrin mRNA…”
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Expression of GDNF and GDNFR-[alpha] mRNAs in muscles of patients with motor neuron diseases by Yamamoto, Masahiko, Mitsuma, Norimasa, Inukai, Akira, Ito, Yasuhiro

“…The mRNA expression levels of GDNF, GDNFR-alpha and RET were examined in the muscles of amyotrophic lateral screlosis (ALS) and X-linked spinal and bulbar…”
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Expression of glial cell line-derived neurotrophic factor and GDNFR-α mRNAs in human peripheral neuropathies by Yamamoto, Masahiko, Mitsuma, Norimasa, Ito, Yasuhiro, Hattori, Naoki, Nagamatsu, Masaaki, Li, Mei, Mitsuma, Terunori, Sobue, Gen

“…The steady-state mRNA levels of glial cell line-derived neurotrophic factor (GDNF), GDNFR-α and RET were examined in various human peripheral neuropathies to…”
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Temporal expression of mRNAs for neuropoietic cytokines, interleukin-11 (IL-11), oncostatin M (OSM), cardiotrophin-1 (CT-1) and their receptors (IL-11Rα and OSMRβ) in peripheral nerve injury by ITO, Yasuhiro, YAMAMOTO, Masahiko, MEI LI, MITSUMA, Norimasa, TANAKA, Fumiaki, DOYU, Manabu, SUZUMURA, Akio, MITSUMA, Terunori, SOBUE, Gen

“…The mRNA expression pattern of the neuropoietic cytokines, interleukin-11 (IL-11), oncostatin M (OSM) and cardiotrophin-1 (CT-1), and their receptor components…”
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Gene expression profile in Alzheimer’s brain screened by molecular indexing by Doyu, Manabu, Sawada, Ko-ichi, Mitsuma, Norimasa, Niwa, Jun-ichi, Yoshimoto, Makoto, Fujii, Yasuyuki, Sobue, Gen, Kato, Kikuya

“…Gene expression in the Alzheimer brain and normal brain was compared by molecular indexing, an advanced version of differential display. Using this technique,…”
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