Search Results - "Mitsui, Marina"

Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling by Kamimura, Hidetaka, Ito, Satoshi, Chijiwa, Hiroyuki, Okuzono, Takeshi, Ishiguro, Tomohiro, Yamamoto, Yosuke, Nishinoaki, Sho, Ninomiya, Shin-Ichi, Mitsui, Marina, Kalgutkar, Amit S., Yamazaki, Hiroshi, Suemizu, Hiroshi

“…1. The partial glucokinase activator N,N-dimethyl-5-((2-methyl-6-((5-methylpyrazin-2-yl)carbamoyl)benzofuran-4-yl)oxy)pyrimidine-2-carboxamide (PF-04937319) is…”
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Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity detected by human serum albumin RNA by Murayama, Norie, Suemizu, Hiroshi, Uehara, Shotaro, Kusama, Takashi, Mitsui, Marina, Kamiya, Yusuke, Shimizu, Makiko, Guengerich, F. Peter, Yamazaki, Hiroshi

“…Lenalidomide has been shown to be potentially teratogenic in thalidomide-sensitive animal species. Screening for thalidomide analogs devoid of…”
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Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology by Yamazaki, Hiroshi, Suemizu, Hiroshi, Mitsui, Marina, Shimizu, Makiko, Guengerich, F. Peter

“…Species differences exist in terms of drug oxidation activities, which are mediated mainly by cytochrome P450 (P450) enzymes. To overcome the problem of…”
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Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice by Shimizu, Makiko, Suemizu, Hiroshi, Mitsui, Marina, Shibata, Norio, Guengerich, F. Peter, Yamazaki, Hiroshi

“…1. Pomalidomide has been shown to be potentially teratogenic in thalidomide-sensitive animal species such as rabbits. Screening for thalidomide analogs devoid…”
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Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling by Utoh, Masahiro, Suemizu, Hiroshi, Mitsui, Marina, Kawano, Mirai, Toda, Akiko, Uehara, Shotaro, Uno, Yasuhiro, Shimizu, Makiko, Sasaki, Erika, Yamazaki, Hiroshi

“…1. The pharmacokinetic data of cytochrome P450 probes in humans can be extrapolated from corresponding data in cynomolgus monkeys, dogs and minipigs using…”
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Human plasma metabolic profiles of benzydamine, a flavin-containing monooxygenase probe substrate, simulated with pharmacokinetic data from control and humanized-liver mice by Yamazaki-Nishioka, Miho, Shimizu, Makiko, Suemizu, Hiroshi, Nishiwaki, Megumi, Mitsui, Marina, Yamazaki, Hiroshi

“…1. Benzydamine is used clinically as a nonsteroidal anti-inflammatory drug in oral rinses and is employed in preclinical research as a flavin-containing…”
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Pollination of soybean (Glycine max L. Merril) by honeybees (Apis mellifera L.) by Chiari, Wainer César, Toledo, Vagner de Alencar Arnaut de, Ruvolo-Takasusuki, Maria Claudia Colla, Oliveira, Arildo José Braz de, Sakaguti, Eduardo Shiguero, Attencia, Valeria Maria, Costa, Fabiana Martins, Mitsui, Marina Hitomi

“…This experiment was carried out to evaluate the effect of the honeybee pollination in the production and quality of soybean seeds (Glycine max L. Merril). Seed…”
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R-warfarin clearances from plasma associated with polymorphic cytochrome P450 2C19 and simulated by individual physiologically based pharmacokinetic models for 11 cynomolgus monkeys by Utoh, Masahiro, Kusama, Takashi, Miura, Tomonori, Mitsui, Marina, Kawano, Mirai, Hirano, Takahiro, Shimizu, Makiko, Uno, Yasuhiro, Yamazaki, Hiroshi

“…1. Cynomolgus monkey cytochrome P450 2C19 (formerly known as P450 2C75), homologous to human P450 2C19, has been identified as R-warfarin 7-hydroxylase. In…”
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Sugar content in nectar flowers of siratro (Macroptilium atropurpureum Urb.) - DOI: 10.4025/actascianimsci.v27i1.1248 by Vagner de Alencar Arnaut de Toledo, Arildo José Braz de Oliveira, Maria Claudia Colla Ruvolo-Takasusuki, Marina Hitumi Mitsui, Renata Eunice Vieira, Carolina Satie Kotaka, Wainer César Chiari, Lucílio Gobbi Filho, Yoko Terada

“…Siratro (Macroptilium atropurpureum Urb.) is a forager with high nutritional values and excellent palatability, and its phenology is almost unknown. Aiming at…”
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Biologia floral e polinização por abelhas em siratro (Macroptilium atropurpureum Urb.) by Renata Eunice Vieira, Carolina Satie Kotaka, Marina Himoti Mitsui, Ana Paula Taniguchi, Vagner de Alencar Arnaut de Toledo, Maria Claudia Colla Ruvolo-Takasusuki, Yoko Terada (in memorian), Silvia Helena Sofia, Fabiana Martins Costa

“…O objetivo deste trabalho foi realizar estudos sobre polinização em siratro, avaliando o período de antese, abelhas visitantes, viabilidade dos grãos de pólen…”
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