Search Results - "Mitsche, Matthew"

Hepatic deletion of Mboat7 (LPIAT1) causes activation of SREBP-1c and fatty liver by Xia, Mingfeng, Chandrasekaran, Preethi, Rong, Shunxing, Fu, Xiaorong, Mitsche, Matthew A.

“…Genetic variants that increase the risk of fatty liver disease and cirrhosis have recently been identified in the proximity of membrane-bound O-acyltransferase…”
Get full text

Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways by Mitsche, Matthew A, McDonald, Jeffrey G, Hobbs, Helen H, Cohen, Jonathan C

“…Two parallel pathways produce cholesterol: the Bloch and Kandutsch-Russell pathways. Here we used stable isotope labeling and isotopomer analysis to trace…”
Get full text

Relative roles of ABCG5/ABCG8 in liver and intestine[S] by Wang, Jin, Mitsche, Matthew A., Lütjohann, Dieter, Cohen, Jonathan C., Xie, Xiao-Song, Hobbs, Helen H.

“…ABCG5 (G5) and ABCG8 (G8) form a sterol transporter that acts in liver and intestine to prevent accumulation of dietary sterols. Mutations in either G5 or G8…”
Get full text

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport by Yang, Chendong, Ko, Bookyung, Hensley, Christopher T., Jiang, Lei, Wasti, Ajla T., Kim, Jiyeon, Sudderth, Jessica, Calvaruso, Maria Antonietta, Lumata, Lloyd, Mitsche, Matthew, Rutter, Jared, Merritt, Matthew E., DeBerardinis, Ralph J.

“…Alternative modes of metabolism enable cells to resist metabolic stress. Inhibiting these compensatory pathways may produce synthetic lethality. We previously…”
Get full text

Insights into lipid accumulation in skeletal muscle in dysferlin-deficient mice by Agarwal, Anil K., Tunison, Katie, Mitsche, Matthew A., McDonald, Jeffrey G., Garg, Abhimanyu

“…Loss of dysferlin (DYSF) protein in humans results in limb-girdle muscular dystrophy 2B, characterized by progressive loss of muscles in the distal limbs with…”
Get full text

Three-phase liquid extraction: a simple and fast method for lipidomic workflows[S] by Vale, Gonçalo, Martin, Sarah A., Mitsche, Matthew A., Thompson, Bonne M., Eckert, Kaitlyn M., McDonald, Jeffrey G.

“…An unbiased sample preparation free of interferents (i.e., competing analytes, detergents, plastics) is critical to any lipid MS workflow. Here we present a…”
Get full text

A Medicinal Chemistry-Driven Approach Identified the Sterol Isomerase EBP as the Molecular Target of TASIN Colorectal Cancer Toxins by Theodoropoulos, Panayotis C, Wang, Wentian, Budhipramono, Albert, Thompson, Bonne M, Madhusudhan, Nikhil, Mitsche, Matthew A, McDonald, Jeffrey G, De Brabander, Jef K, Nijhawan, Deepak

“…TASIN (Truncated APC-Selective Inhibitors) compounds are selectively toxic to colorectal cancer cells with APC mutations, although their mechanism of action…”
Get full text

Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis by Padanad, Mahesh S., Konstantinidou, Georgia, Venkateswaran, Niranjan, Melegari, Margherita, Rindhe, Smita, Mitsche, Matthew, Yang, Chendong, Batten, Kimberly, Huffman, Kenneth E., Liu, Jingwen, Tang, Ximing, Rodriguez-Canales, Jaime, Kalhor, Neda, Shay, Jerry W., Minna, John D., McDonald, Jeffrey, Wistuba, Ignacio I., DeBerardinis, Ralph J., Scaglioni, Pier Paolo

“…KRAS is one of the most commonly mutated oncogenes in human cancer. Mutant KRAS aberrantly regulates metabolic networks. However, the contribution of cellular…”
Get full text

Measurement of lipogenic flux by deuterium resolved mass spectrometry by Fu, Xiaorong, Deja, Stanisław, Fletcher, Justin A., Anderson, Norma N., Mizerska, Monika, Vale, Gonçalo, Browning, Jeffrey D., Horton, Jay D., McDonald, Jeffrey G., Mitsche, Matthew A., Burgess, Shawn C.

“…De novo lipogenesis (DNL) is disrupted in a wide range of human disease. Thus, quantification of DNL may provide insight into mechanisms and guide…”
Get full text

Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance[S] by Moon, Young-Ah, Ochoa, Courtney R., Mitsche, Matthew A., Hammer, Robert E., Horton, Jay D.

“…Elongation of very long chain fatty acid-like family member 6 (ELOVL6) is a fatty acyl elongase that performs the initial and rate-limiting condensing reaction…”
Get full text

Low MBOAT7 expression, a genetic risk for MASH, promotes a profibrotic pathway involving hepatocyte TAZ upregulation by Moore, Mary P., Wang, Xiaobo, Kennelly, John Paul, Shi, Hongxue, Ishino, Yuki, Kano, Kuniyuki, Aoki, Junken, Cherubini, Alessandro, Ronzoni, Luisa, Guo, Xiuqing, Chalasani, Naga P., Khalid, Shareef, Saleheen, Danish, Mitsche, Matthew A., Rotter, Jerome I., Yates, Katherine P., Valenti, Luca, Kono, Nozomu, Tontonoz, Peter, Tabas, Ira

“…Background and Aims: The common genetic variant rs641738 C>T is a risk factor for metabolic dysfunction–associated steatotic liver disease and metabolic…”
Get full text

Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition by Gao, Lu, Rabbitt, Elizabeth H, Condon, Jennifer C, Renthal, Nora E, Johnston, John M, Mitsche, Matthew A, Chambon, Pierre, Xu, Jianming, O'Malley, Bert W, Mendelson, Carole R

“…The precise mechanisms that lead to parturition are incompletely defined. Surfactant protein-A (SP-A), which is secreted by fetal lungs into amniotic fluid…”
Get full text

Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver by Hwang, Seonghwan, Hartman, Isamu Z., Calhoun, Leona N., Garland, Kristina, Young, Gennipher A., Mitsche, Matthew A., McDonald, Jeffrey, Xu, Fang, Engelking, Luke, DeBose-Boyd, Russell A.

“…Accumulation of sterols in endoplasmic reticulum membranes stimulates the ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), which…”
Get full text

Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets by Mitsche, Matthew A., Hobbs, Helen H., Cohen, Jonathan C.

“…Fatty liver disease (FLD) is a burgeoning health problem. A missense variant (I148M) in patatin-like phospholipase domain–containing protein 3 (PNPLA3) confers…”
Get full text

C-Terminus of Apolipoprotein A-I Removes Phospholipids from a Triolein/Phospholipids/Water Interface, but the N-Terminus Does Not: A Possible Mechanism for Nascent HDL Assembly by Mitsche, Matthew A., Small, Donald M.

“…Apolipoprotein A-I (ApoA-I) is the principle protein component of HDL, also known as “good cholesterol,” which is an inverse marker for cardiovascular disease…”
Get full text

Adsorption of Egg Phosphatidylcholine to an Air/Water and Triolein/Water Bubble Interface: Use of the 2-Dimensional Phase Rule To Estimate the Surface Composition of a Phospholipid/Triolein/Water Surface as a Function of Surface Pressure by Mitsche, Matthew A, Wang, Libo, Small, Donald M

“…Phospholipid monolayers play a critical role in the structure and stabilization of biological interfaces, including all membranes, the alveoli of the lungs,…”
Get full text

Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress by Chimalapati, Suneeta, de Souza Santos, Marcela, Lafrance, Alexander E, Ray, Ann, Lee, Wan-Ru, Rivera-Cancel, Giomar, Vale, Gonçalo, Pawlowski, Krzysztof, Mitsche, Matthew A, McDonald, Jeffrey G, Liou, Jen, Orth, Kim

“…Pathogens find diverse niches for survival including inside a host cell where replication occurs in a relatively protective environment. is a facultative…”
Get full text

Surface pressure-dependent conformation change of apolipoprotein-derived amphipathic α-helices by Mitsche, Matthew A., Small, Donald M.

“…Amphipathic α-helices (AαH) are the primary structural motif of exchangeable apolipoproteins. AαHs in exchangeable apolipoproteins adsorb, remodel, and desorb…”
Get full text

The adsorption of biological peptides and proteins at the oil/water interface. A potentially important but largely unexplored field by Small, Donald M., Wang, Libo, Mitsche, Matthew A.

“…This review focuses on some new techniques to study the behavior of peptides and proteins bound to oil droplets. We will show how model peptides e.g.,…”
Get full text

Surface Tensiometry of Apolipoprotein B Domains at Lipid Interfaces Suggests a New Model for the Initial Steps in Triglyceride-rich Lipoprotein Assembly by Mitsche, Matthew A., Packer, Laura E., Brown, Jeffrey W., Jiang, Z.Gordon, Small, Donald M., McKnight, C.James

“…Apolipoprotein B (apoB) is the principal protein component of triacylglyceride (TAG)-rich lipoproteins, including chylomicrons and very low density…”
Get full text