Search Results - "Mitrophanous, K"

Oviduct-specific expression of two therapeutic proteins in transgenic hens by Lillico, S.G, Sherman, A, McGrew, M.J, Robertson, C.D, Smith, J, Haslam, C, Barnard, P, Radcliffe, P.A, Mitrophanous, K.A, Elliot, E.A, Sang, H.M

“…Recent advances in avian transgenesis have led to the possibility of utilizing the laying hen as a production platform for the large-scale synthesis of…”
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Enhancing titres of therapeutic viral vectors using the transgene repression in vector production (TRiP) system by Maunder, H. E., Wright, J., Kolli, B. R., Vieira, C. R., Mkandawire, T. T., Tatoris, S., Kennedy, V., Iqball, S., Devarajan, G., Ellis, S., Lad, Y., Clarkson, N. G., Mitrophanous, K. A., Farley, D. C.

“…A key challenge in the field of therapeutic viral vector/vaccine manufacturing is maximizing production. For most vector platforms, the ‘benchmark’ vector…”
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Optogenetic Tractography for anatomo-functional characterization of cortico-subcortical neural circuits in non-human primates by Senova, S., Poupon, C., Dauguet, J., Stewart, H. J., Dugué, G. P., Jan, C., Hosomi, K., Ralph, G. S., Barnes, L., Drouot, X., Pouzat, C., Mangin, J. F., Pain, F., Doignon, I., Aron-Badin, R., Brouillet, E., Boyden, E. S., Mitrophanous, K. A., Hantraye, P., Palfi, S.

“…Dissecting neural circuitry in non-human primates (NHP) is crucial to identify potential neuromodulation anatomical targets for the treatment of…”
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Stable gene transfer to the nervous system using a non-primate lentiviral vector by MITROPHANOUS, K. A, YOON, S, ROHLL, J. B, PATIL, D, WILKES, F. J, KIM, V. N, KINGSMAN, S. M, KINGSMAN, A. J, MAZARAKIS, N. D

“…We have constructed a non-primate lentiviral vector system based on the equine infectious anaemia virus (EIAV). This system is able to transduce both dividing…”
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Hsp40 Molecules That Target to the Ubiquitin-proteasome System Decrease Inclusion Formation in Models of Polyglutamine Disease by Howarth, J L, Kelly, S, Keasey, M P, Glover, Cpj, Lee, Y-B, Mitrophanous, K, Chapple, J P, Gallo, J M, Cheetham, M E, Uney, J B

“…We studied the ability of heat shock, DnaJ-like-1 (HSJ1) proteins (which contain DnaJ and ubiquitin-interacting motifs) to reduce polyglutamine-mediated…”
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Gene transduction efficiency in cells of different species by HIV and EIAV vectors by IKEDA, Y, COLLINS, M. K. L, RADCLIFFE, P. A, MITROPHANOUS, K. A, TAKEUCHI, Y

“…The ability of human immunodeficiency virus (HIV)- and equine infectious anaemia virus (EIAV)-based vectors to transduce cell lines from a range of species was…”
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Hsp40 Molecules That Target to the Ubiquitin-proteasome System Decrease Inclusion Formation in Models of Polyglutamine Disease by Howarth, JL, Kelly, S, Keasey, MP, Glover, CPJ, Lee, Y-B, Mitrophanous, K, Chapple, JP, Gallo, JM, Cheetham, ME, Uney, JB

“…We studied the ability of heat shock, DnaJ-like-1 (HSJ1) proteins (which contain DnaJ and ubiquitin-interacting motifs) to reduce polyglutamine-mediated…”
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Potential oncogene activity of the woodchuck hepatitis post-transcriptional regulatory element (WPRE) by Kingsman, S M, Mitrophanous, K, Olsen, J C

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Development of inducible EIAV-based lentiviral vector packaging and producer cell lines by Stewart, H J, Leroux-Carlucci, M A, Sion, C J M, Mitrophanous, K A, Radcliffe, P A

“…Large-scale production of gene therapeutics comprising equine infectious anaemia virus (EIAV) -based lentiviral vectors (LVs) would benefit from the…”
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Analysis of factor VIII mediated suppression of lentiviral vector titres by Radcliffe, P A, Sion, C J M, Wilkes, F J, Custard, E J, Beard, G L, Kingsman, S M, Mitrophanous, K A

“…Effective gene therapy for haemophilia A necessitates a vector system that is not subject to a pre-existing immune response, has adequate coding capacity,…”
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Long-term transgene expression by administration of a lentivirus-based vector to the fetal circulation of immuno-competent mice by WADDINGTON, S. N, MITROPHANOUS, K. A, COUTELLE, C, THEMIS, M, ELLARD, F. M, BUCKLEY, S. M. K, NIVSARKAR, M, LAWRENCE, L, COOK, H. T, AL-ALLAF, F, BIGGER, B, KINGSMAN, S. M

“…Inefficient gene transfer, inaccessibility of stem cell compartments, transient gene expression, and adverse immune and inflammatory reactions to vector and…”
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Multiple gene products from a single vector: 'self-cleaving' 2A peptides by Radcliffe, PA, Mitrophanous, KA

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Highly efficient EIAV-mediated in utero gene transfer and expression in the major muscle groups affected by Duchenne muscular dystrophy by GREGORY, L. G, WADDINGTON, S. N, AL-ALLAF, F, KINGSMAN, S, COUTELLE, C, THEMIS, M, HOLDER, M. V, MITROPHANOUS, K. A, BUCKLEY, S. M. K, MOSLEY, K. L, BIGGER, B. W, ELLARD, F. M, WALMSLEY, L. E, LAWRENCE, L

“…Gene therapy for Duchenne muscular dystrophy has so far not been successful because of the difficulty in achieving efficient and permanent gene transfer to the…”
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Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery by MAZARAKIS, Nicholas D, AZZOUZ, Mimoun, KINGSMAN, Alan J, O'MALLEY, Karen, MITROPHANOUS, Kyriacos A, ROHLL, Jonathan B, ELLARD, Fiona M, WILKES, Fraser J, OLSEN, Anna L, CARTER, Emma E, BARBER, Robert D, BABAN, Dilair F, KINGSMAN, Susan M

“…In this report it is demonstrated for the first time that rabies-G envelope of the rabies virus is sufficient to confer retrograde axonal transport to a…”
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In vivo evaluation of an EIAV vector for the systemic genetic delivery of therapeutic antibodies by LAMIKANRA, A, MYERS, K. A, FERRIS, N, MITROPHANOUS, K. A, CARROLL, M. W

“…Lentiviral-based vectors hold great promise as gene delivery vehicles for the treatment of a wide variety of diseases. We have previously reported the…”
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A replication competent lentivirus (RCL) assay for equine infectious anaemia virus (EIAV)-based lentiviral vectors by MISKIN, J, CHIPCHASE, D, ROHLL, J, BEARD, G, WARDELL, T, ANGELL, D, ROEHL, H, JOLLY, D, KINGSMAN, S, MITROPHANOUS, K

“…Lentiviral vectors are being developed to satisfy a wide range of currently unmet medical needs. Vectors destined for clinical evaluation have been rendered…”
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A Rev-independent human immunodeficiency virus type 1 (HIV-1)-based vector that exploits a codon-optimized HIV-1 gag-pol gene by Kotsopoulou, E, Kim, V N, Kingsman, A J, Kingsman, S M, Mitrophanous, K A

“…The human immunodeficiency virus (HIV) genome is AU rich, and this imparts a codon bias that is quite different from the one used by human genes. The codon…”
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P2.205 A phase I/II clinical trial to evaluate the safety and efflcacy of ProSavin®, a gene therapy approach for Parkinson's disease by Jarraya, B, Lepetit, H, Ralph, S, Boulet, S, Jan, C, Bonvento, G, Miskin, J, Gurruchaga, J.-M, Vinti, M, Fenelon, G, Brugière, P, Kingsman, S, Hantraye, P, Remy, P, Mitrophanous, K, Palfl, S

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THE TETRAVECTA™ SYSTEM: A NEW TOOL KIT ENHANCING LENTIVIRAL VECTOR PRODUCTION FOR THE NEXT GENERATION OF GENE THERAPIES by Wright, J., Alberts, B., Mitrophanous, K., Clarkson, N., Farley, D., Kazarian, K., Hove, S.

“…The use of HIV-1 based lentiviral vectors (LVs) remains the most established and efficient means to deliver transgenes to non-/dividing cells, achieving…”
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Growth factor enhanced retroviral gene transfer to the adult central nervous system by KING, L. A, MITROPHANOUS, K. A, CLARK, L. A, KIM, V. N, ROHLL, J. B, KINGSMAN, A. J, COLELLO, R. J

“…The use of viral vectors for gene delivery into mammalian cells provides a new approach in the treatment of many human diseases. The first viral vector…”
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