Search Results - "Mitroka, J"

Disposition of Radiolabeled Ifetroban in Rats, Dogs, Monkeys, and Humans by DOCKENS, R. C, SANTONE, K. S, MITROKA, J. G, MORRISON, R. A, JEMAL, M, GREENE, D. S, BARBHAIYA, R. H

“…Ifetroban is a potent and selective thromboxane receptor antagonist. This study was conducted to characterize the pharmacokinetics, absolute bioavailability,…”
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Modeling the complexity of different, recently deglaciated soil landscapes as a function of map scale by Hupy, Christina M., Schaetzl, Randall J., Messina, Joseph P., Hupy, Joseph P., Delamater, Paul, Enander, Helen, Hughey, Brandi D., Boehm, Rebecca, Mitroka, Matthew J., Fashoway, Michael T.

“…The scale at which a soil landscape (soilscape) is viewed has a significant impact on soil pattern and interpretations made from those patterns. Recently…”
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Oral Bioavailability and Disposition of [14C]Omapatrilat in Healthy Subjects by Malhotra, Bimal K., Iyer, Ramaswamy A., Soucek, Kathy M., Behr, Douglas, Liao, Wei-chi, Mitroka, James G., Kaul, Sanjeev, Cohen, Marvin B., Knupp, Catherine A.

“…The objective of this study was to determine the absolute oral bioavailability and disposition of omapatrilat. This singledose, randomized, crossover study of…”
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Analysis of low level radioactive metabolites in biological fluids using high-performance liquid chromatography with microplate scintillation counting: Method validation and application by Zhu, Mingshe, Zhao, Weiping, Vazquez, Natasha, Mitroka, James G.

“…TopCount, a microplate scintillation counter (MSC), has been recently employed as an off-line liquid radiochromatographic detector for radioactive metabolite…”
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Oral Bioavailability and Anti-Simian Varicella Virus Efficacy of 1-β-D-Arabinofuranosyl-E-5-(2-Bromovinyl)Uracil (BV-araU) in Monkeys by Soike, K., Huang, J.-L., Tu, J.-I., Stouffer, B., Mitroka, J. G., Swerdel, M., Olsen, S., Bonner, D. P., Tuomari, A. V., Field, A. K.

“…BV-araU (1-β-D-arabinofuranosyl-E-5-[2-bromovinyl]uracil) has potent antiviral activity against varicella zoster virus in cell culture and is undergoing…”
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CYTOCHROME P450 3A-MEDIATED METABOLISM OF BUSPIRONE IN HUMAN LIVER MICROSOMES by Zhu, Mingshe, Zhao, Weiping, Jimenez, Humberto, Zhang, Donglu, Yeola, Suresh, Dai, Renke, Vachharajani, Nimish, Mitroka, James

“…This study was carried out to determine the metabolic pathways of buspirone and cytochrome P450 (P450) isoform(s) responsible for buspirone metabolism in human…”
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BMS-180448, a novel glyburide-reversible cardioprotective agent, enhances postischemic recovery of contractile function in dogs by Grover, G J, Parham, C S, Whigan, D B, Mitroka, J G

“…BMS-180448 has been found to retain the cardioprotective potency of its chemically related analog, cromakalim, although having significantly less peripheral…”
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METABOLISM, PHARMACOKINETICS, AND PROTEIN COVALENT BINDING OF RADIOLABELED MAXIPOST (BMS-204352) IN HUMANS by ZHANG, Donglu, KRISHNA, Rajesh, WANG, Lifei, ZENG, Jianing, MITROKA, James, DAI, Renke, NARASIMHAN, Narayanan, REEVES, Richard A, SRINIVAS, Nuggehally R, KLUNK, Lewis J

“…MaxiPost [(3 S )-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2 H -indole-2-one); BMS-204352] is an investigational maxi-K channel…”
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Rapid metabolic inactivation of tipredane, a structurally novel topical steroid by Lan, S J, Scanlan, L M, Mitroka, J, Weinstein, S H, Lutsky, B N, Free, C A, Wojnar, R J, Millonig, R C, Migdalof, B H

“…[3H]Tipredane ([3H]TP), [3H]triamcinolone acetonide ([ 3H]TAAC), [3H]hydrocortisone ([3H]HC), and [3H]betamethasone-17 alpha-valerate ([3H]BMV), each at a…”
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PROTEIN COVALENT BINDING OF MAXIPOST THROUGH A CYTOCHROME P450-MEDIATED ORTHO-QUINONE METHIDE INTERMEDIATE IN RATS by DONGLU ZHANG, OGAN, Marc, GEDAMKE, Richard, ROONGTA, Vikram, DAI, Renke, MINGSHE ZHU, RINEHART, J. Kent, KLUNK, Lewis, MITROKA, James

“…(3 S )-(+)-(5-Chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2 H -indole-2-one) (MaxiPost, BMS-204352) is a potent and specific opener for…”
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Cerebrospinal fluid retrieval in the conscious dog: a methods development study by Rockar, R A, Sandanaga, K K, Burkett, D E, Mitroka, J G, Bonner, R A, Weinstein, M J

“…A chronic cerebrospinal fluid access system is described for use in the conscious sling-restrained dog. In a pilot study of ten dogs, a fenestrated…”
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Comparative Biotransformation of Radiolabeled [14C]Omapatrilat and Stable-labeled [13C2]Omapatrilat after Oral Administration to Rats, Dogs, and Humans by Ramaswamy A. Iyer, Bimal Malhotra, Sanaullah Khan, James Mitroka, Samuel Bonacorsi, Jr, Stephen C. Waller, J. Kent Rinehart, Kishin Kripalani

“…Omapatrilat, a novel vasopeptidase inhibitor, is under development for the treatment of hypertension and congestive heart failure. This study describes the…”
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Metabolism of [14C]Omapatrilat, a Sulfhydryl-Containing Vasopeptidase Inhibitor in Humans by Ramaswamy A. Iyer, James Mitroka, Bimal Malhotra, Samuel Bonacorsi, Jr, Stephen C. Waller, J. Kent Rinehart, Vikram A. Roongta, Kishin Kripalani

“…Omapatrilat, a potent vasopeptidase inhibitor, is currently under development for the treatment of hypertension and congestive heart failure. This study…”
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AMIDE N-GLUCURONIDATION OF MAXIPOST CATALYZED BY UDP-GLUCURONOSYLTRANSFERASE 2B7 IN HUMANS by DONGLU ZHANG, WEIPING ZHAO, ROONGTA, Vikram A, MITROKA, James G, KLUNK, Lewis J, MINGSHE ZHU

“…MaxiPost [(3 S )-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2 H -indole-2-one), or BMS-204352)] is a potent and specific maxi-K…”
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Oral Bioavailability and Anti-Simian Varicella Virus Efficacy of 1- -D-Arabinofuranosyl-E-5-(2-Bromovinyl)Uracil (BV-araU) in Monkeys by Soike, K., Huang, J.- L., Tu, J.- I., Stouffer, B., Mitroka, J. G., Swerdel, M., Olsen, S., Bonner, D. P., Tuomari, A. V., Field, A. K.

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Strategy for Passing the Civil P.E. Exam by Everett, John G, Mitroka, James T

“…The Principles and Practice of Engineering examination is the final challenge in earning registration as a licensed professional engineer (P.E.). Many…”
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