Search Results - "Mitroi, Daniel N."

SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production by Mitroi, Daniel N., Karunakaran, Indulekha, Gräler, Markus, Saba, Julie D., Ehninger, Dan, Ledesma, María Dolores, van Echten-Deckert, Gerhild

“…Macroautophagy/autophagy defects have been identified as critical factors underlying the pathogenesis of neurodegenerative diseases. The roles of the bioactive…”
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Enhanced mGluR5 intracellular activity causes psychiatric alterations in Niemann Pick type C disease by Toledano-Zaragoza, Ana, Enriquez-Zarralanga, Violeta, Naya-Forcano, Sara, Briz, Víctor, Alfaro-Ruíz, Rocío, Parra-Martínez, Miguel, Mitroi, Daniel N., Luján, Rafael, Esteban, José A., Ledesma, María Dolores

“…Niemann-Pick disease Type C (NPC) is caused by mutations in the cholesterol transport protein NPC1 leading to the endolysosomal accumulation of the lipid and…”
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Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism by Mitroi, Daniel N., Deutschmann, André U., Raucamp, Maren, Karunakaran, Indulekha, Glebov, Konstantine, Hans, Michael, Walter, Jochen, Saba, Julie, Gräler, Markus, Ehninger, Dan, Sopova, Elena, Shupliakov, Oleg, Swandulla, Dieter, van Echten-Deckert, Gerhild

“…The bioactive lipid sphingosine 1-phosphate (S1P) is a degradation product of sphingolipids that are particularly abundant in neurons. We have shown previously…”
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Oxidative Stress and Histopathological Changes in Gills and Kidneys of Cyprinus carpio following Exposure to Benzethonium Chloride, a Cationic Surfactant by Gheorghe, Stefania, Stan, Miruna S, Mitroi, Daniel N, Staicu, Andrea C, Cicirma, Marius, Lucaciu, Irina E, Nita-Lazar, Mihai, Dinischiotu, Anca

“…One cationic surfactant with a wide spectrum of microbiocidal activity is benzethonium chloride (BEC). Despite being widely used, the toxicity data on…”
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Single‐nucleus transcriptome analysis reveals disease‐ and regeneration‐associated endothelial cells in white matter vascular dementia by Mitroi, Daniel N., Tian, Min, Kawaguchi, Riki, Lowry, William E., Carmichael, S. Thomas

“…Background Vascular dementia (VaD) is the accumulation of vascular lesions in the subcortical white matter of the brain. These lesions progress and there is no…”
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NPC1 enables cholesterol mobilization during long‐term potentiation that can be restored in Niemann–Pick disease type C by CYP46A1 activation by Mitroi, Daniel N, Pereyra‐Gómez, Guadalupe, Soto‐Huelin, Beatriz, Senovilla, Fernando, Kobayashi, Toshihide, Esteban, Jose A, Ledesma, María Dolores

“…NPC is a neurodegenerative disorder characterized by cholesterol accumulation in endolysosomal compartments. It is caused by mutations in the gene encoding…”
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Lipid‐induced lysosomal damage after demyelination corrupts microglia protective function in lysosomal storage disorders by Gabandé‐Rodríguez, Enrique, Pérez‐Cañamás, Azucena, Soto‐Huelin, Beatriz, Mitroi, Daniel N, Sánchez‐Redondo, Sara, Martínez‐Sáez, Elena, Venero, César, Peinado, Héctor, Ledesma, María Dolores

“…Neuropathic lysosomal storage disorders (LSDs) present with activated pro‐inflammatory microglia. However, anti‐inflammatory treatment failed to improve…”
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Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects by Kalinichenko, Liubov S., Mühle, Christiane, Jia, Tianye, Anderheiden, Felix, Datz, Maria, Eberle, Anna-Lisa, Eulenburg, Volker, Granzow, Jonas, Hofer, Martin, Hohenschild, Julia, Huber, Sabine E., Kämpf, Stefanie, Kogias, Georgios, Lacatusu, Laura, Lugmair, Charlotte, Taku, Stephen Mbu, Meixner, Doris, Tesch, Nina, Praetner, Marc, Rhein, Cosima, Sauer, Christina, Scholz, Jessica, Ulrich, Franziska, Valenta, Florian, Weigand, Esther, Werner, Markus, Tay, Nicole, Mc Veigh, Conor J., Haase, Jana, Wang, An-Li, Abdel-Hafiz, Laila, Huston, Joseph P., Smaga, Irena, Frankowska, Malgorzata, Filip, Malgorzata, Lourdusamy, Anbarasu, Kirchner, Philipp, Ekici, Arif B., Marx, Lena M., Suresh, Neeraja Puliparambil, Frischknecht, Renato, Fejtova, Anna, Saied, Essa M., Arenz, Christoph, Bozec, Aline, Wank, Isabel, Kreitz, Silke, Hess, Andreas, Bäuerle, Tobias, Ledesma, Maria Dolores, Mitroi, Daniel N., Miranda, André M., Oliveira, Tiago G., Gulbins, Erich, Lenz, Bernd, Schumann, Gunter, Kornhuber, Johannes, Müller, Christian P.

“…Mental disorders are highly comorbid and occur together with physical diseases, which are often considered to arise from separate pathogenic pathways. We…”
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Adult alcohol drinking and emotional tone are mediated by neutral sphingomyelinase during development in males by Kalinichenko, Liubov S, Mühle, Christiane, Jia, Tianye, Anderheiden, Felix, Datz, Maria, Eberle, Anna-Lisa, Eulenburg, Volker, Granzow, Jonas, Hofer, Martin, Hohenschild, Julia, Huber, Sabine E, Kämpf, Stefanie, Kogias, Georgios, Lacatusu, Laura, Lugmair, Charlotte, Taku, Stephen Mbu, Meixner, Doris, Sembritzki, Nina-Kristin, Praetner, Marc, Rhein, Cosima, Sauer, Christina, Scholz, Jessica, Ulrich, Franziska, Valenta, Florian, Weigand, Esther, Werner, Markus, Tay, Nicole, Mc Veigh, Conor J, Haase, Jana, Wang, An-Li, Abdel-Hafiz, Laila, Huston, Joseph P, Smaga, Irena, Frankowska, Malgorzata, Filip, Malgorzata, Lourdusamy, Anbarasu, Kirchner, Philipp, Ekici, Arif B, Marx, Lena M, Suresh, Neeraja Puliparambil, Frischknecht, Renato, Fejtova, Anna, Saied, Essa M, Arenz, Christoph, Bozec, Aline, Wank, Isabel, Kreitz, Silke, Hess, Andreas, Bäuerle, Tobias, Ledesma, Maria Dolores, Mitroi, Daniel N, Miranda, André M, Oliveira, Tiago Gil, Lenz, Bernd, Schumann, Gunter, Kornhuber, Johannes, Müller, Christian P

“…Alcohol use, abuse, and addiction, and resulting health hazards are highly sex-dependent with unknown mechanisms. Previously, strong links between the SMPD3…”
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Evaluation of Sub-Lethal Toxicity of Benzethonium Chloride in Cyprinus carpio Liver by Gheorghe, Stefania, Mitroi, Daniel N., Stan, Miruna S., Staicu, Cristina A., Cicirma, Marius, Lucaciu, Irina E., Nita-Lazar, Mihai, Dinischiotu, Anca

“…Benzenthonium chloride (BEC, Hyamine 1622) is a quaternary ammonium surfactant with cationic properties widely used in cleaning, sanitation, and medical…”
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NPC 1 enables cholesterol mobilization during long‐term potentiation that can be restored in Niemann–Pick disease type C by CYP 46A1 activation by Mitroi, Daniel N, Pereyra‐Gómez, Guadalupe, Soto‐Huelin, Beatriz, Senovilla, Fernando, Kobayashi, Toshihide, Esteban, Jose A, Ledesma, María Dolores

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Enhanced mGluR 5 intracellular activity causes psychiatric alterations in Niemann Pick type C disease by Toledano-Zaragoza, Ana, Enriquez-Zarralanga, Violeta, Naya-Forcano, Sara, Briz, Víctor, Alfaro-Ruíz, Rocío, Parra-Martínez, Miguel, Mitroi, Daniel N, Luján, Rafael, Esteban, José A, Ledesma, María Dolores

“…Niemann-Pick disease Type C (NPC) is caused by mutations in the cholesterol transport protein NPC1 leading to the endolysosomal accumulation of the lipid and…”
Get full text