Search Results - "Mitran, B."

Affibody-derived drug conjugates: Potent cytotoxic molecules for treatment of HER2 over-expressing tumors by Altai, Mohamed, Liu, Hao, Ding, Haozhong, Mitran, Bogdan, Edqvist, Per-Henrik, Tolmachev, Vladimir, Orlova, Anna, Gräslund, Torbjörn

“…Patients with HER2-positive tumors often suffer resistance to therapy, warranting development of novel treatment modalities. Affibody molecules are small…”
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Affibody-mediated PET imaging of HER3 expression in malignant tumours by Rosestedt, Maria, Andersson, Ken G., Mitran, Bogdan, Tolmachev, Vladimir, Löfblom, John, Orlova, Anna, Ståhl, Stefan

“…Human epidermal growth factor receptor 3 (HER3) is involved in the progression of various cancers and in resistance to therapies targeting the HER family. In…”
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Optimizing affibody-mediated PET imaging of HER3 expression using long-lived radiocobalt for the next day PET image by Rinne, S., Leitao, Charles Dahlsson, Mitran, B., Tolmachev, V., Ståhl, Stefan, Löfblom, John, Orlova, A.

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Comparative in vivo biodistribution and dosimetry in non-human primate of the fibroblast activation protein radiotracers [68Ga]Ga-FAPI-04, [68Ga]Ga-FAPI-46 and [18F]FAPI-74 by Tran, Thuy, Bolin, Martin, Dahl, Kenneth, Johnstrom, Peter, Mitran, Bogdan, Siikanen, Jonathan, Schou, Magnus

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Comparative Evaluation of Two DARPin Variants: Effect of Affinity, Size, and Label on Tumor Targeting Properties by Deyev, Sergey, Vorobyeva, Anzhelika, Schulga, Alexey, Proshkina, Galina, Güler, Rezan, Löfblom, John, Mitran, Bogdan, Garousi, Javad, Altai, Mohamed, Buijs, Jos, Chernov, Vladimir, Orlova, Anna, Tolmachev, Vladimir

“…Designed ankyrin repeat proteins (DARPins) are small engineered scaffold proteins that can be selected for binding to desirable molecular targets. High…”
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Noninvasive PET Detection of CD69-Positive Immune Cells Before Signs of Clinical Disease in Inflammatory Arthritis by Puuvuori, Emmi, Shen, Yunbing, Hulsart-Billström, Gry, Mitran, Bogdan, Zhang, Bo, Cheung, Pierre, Wegrzyniak, Olivia, Ingvast, Sofie, Persson, Jonas, Ståhl, Stefan, Korsgren, Olle, Löfblom, John, Wermeling, Fredrik, Eriksson, Olof

“…Rheumatoid arthritis (RA) is the most common inflammatory joint disease, and early diagnosis is key for effective disease management. CD69 is one of the…”
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PP#176 - Comparative evaluation of anti-EGFR affibody molecules labelled with gallium-68 and zirconium-89 using DFO chelator by Maryam, O., Javad, G., Andersson, K., Löfblom, J., Mitran, B., Orlova, A., Tolmachev, V.

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Comparative evaluation of anti-EGFR affibody molecules labelled with gallium-68 and zirconium-89 using DFO chelator by Maryam, O., Javad, G., Andersson, K., Löfblom, J., Mitran, B., Orlova, A., Tolmachev, V.

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A novel method for conjugation of PNA to antibodies for radionuclide based pretargeting: proof of principal by Altai, M., Vorobyeva, A., Westerlund, Kristina, Mitran, B., Orlova, A., Eriksson Karlström, Amelie, Tolmachev, V.

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Trastuzumab co-treatment improves survival of mice with PC-3 prostate cancer xenografts treated with [177Lu]Lu-DOTAGA-PEG2-RM26 GRPR antagonists by Mitran, B., Rinne, S., Vorobyeva, A., Altai, M., Konijnenberg, M., Maina, T., Nock, B., Tolmachev, V., Rosenström, U., Orlova, A.

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OP#55 - Trastuzumab co-treatment improves survival of mice with PC-3 prostate cancer xenografts treated with [177Lu]Lu-DOTAGA-PEG2-RM26 GRPR antagonists by Mitran, B., Rinne, S., Vorobyeva, A., Altai, M., Konijnenberg, M., Maina, T., Nock, B., Tolmachev, V., Rosenström, U., Orlova, A.

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Radionuclide tumor targeting using ADAPT scaffold proteins: aspects of label positioning and residualizing properties of the label by Garousi, J., Lindbo, Sarah, Mitran, B., Altai, M., Buijs, J., Orlova, A., Hober, Sophia, Tolmachev, V.

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Comparison Of Affibody- And Antibody Fragments-based Caix Imaging Probes In Mice Bearing Renal Cell Carcinoma Xenografts by Garousi, J., Huizing, F., Vorobyeva, A., Mitran, B., Andersson, Ken G., Leitao, Charles Dahlsson, Frejd, F., Löfblom, John, Bussink, J., Orlova, A., Heskamp, S., Tolmachev, V.

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Selection Of The Optimal Macrocyclic Chelators For Labelling With In-111 And Ga-68 Improves Contrast Of Her2 Imaging Using Engineered Scaffold Protein Adapt6 by Garousi, J., von Witting, Emma, Lindbo, Sarah, Vorobyeva, A., Altai, M., Oroujeni, M., Mitran, B., Orlova, A., Hober, Sophia, Tolmachev, V.

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Pretargeted radionuclide therapy of HER2-expressing SKOV-3 human xenografts using an Affibody molecule-based PNA-mediated pretargeting by Altai, M., Westerlund, Kristina, Konijnenberg, M., Mitran, B., Oroujeni, M., de Jong, M., Eriksson Karlström, Amelie, Orlova, A., Tolmachev, V.

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Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer—Optimization of the Affinity towards PSMA by Linker Modification in Murine Model by Lundmark, Fanny, Abouzayed, Ayman, Mitran, Bogdan, Rinne, Sara S., Varasteh, Zohreh, Larhed, Mats, Tolmachev, Vladimir, Rosenström, Ulrika, Orlova, Anna

“…Prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPR) are promising targets for molecular imaging of prostate cancer (PCa)…”
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Development of an optimal imaging strategy for selection of patients for affibody-based PNA-mediated radionuclide therapy by Vorobyeva, Anzhelika, Westerlund, Kristina, Mitran, Bogdan, Altai, Mohamed, Rinne, Sara, Sörensen, Jens, Orlova, Anna, Tolmachev, Vladimir, Karlström, Amelie Eriksson

“…Affibody molecules are engineered scaffold proteins, which demonstrated excellent binding to selected tumor-associated molecular abnormalities in vivo and…”
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Molecular Design of HER3-Targeting Affibody Molecules: Influence of Chelator and Presence of HEHEHE-Tag on Biodistribution of 68 Ga-Labeled Tracers by Dahlsson Leitao, Charles, Rinne, Sara S, Mitran, Bogdan, Vorobyeva, Anzhelika, Andersson, Ken G, Tolmachev, Vladimir, Ståhl, Stefan, Löfblom, John, Orlova, Anna

“…Affibody-based imaging of HER3 is a promising approach for patient stratification. We investigated the influence of a hydrophilic HEHEHE-tag ((HE)₃-tag) and…”
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Evaluation of a radiocobalt-labelled affibody molecule for imaging of human epidermal growth factor receptor 3 expression by Rosestedt, Maria, Andersson, Ken G, Mitran, Bogdan, Rinne, Sara S, Tolmachev, Vladimir, Löfblom, John, Orlova, Anna, Ståhl, Stefan

“…The human epidermal growth factor receptor 3 (HER3) is involved in the development of cancer resistance towards tyrosine kinase-targeted therapies. Several…”
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Evaluation of affibody molecule-based PNA-mediated radionuclide pretargeting: Development of an optimized conjugation protocol and 177Lu labeling by Altai, Mohamed, Westerlund, Kristina, Velletta, Justin, Mitran, Bogdan, Honarvar, Hadis, Karlström, Amelie Eriksson

“…We have previously developed a pretargeting approach for affibody-mediated cancer therapy based on PNA–PNA hybridization. In this article we have further…”
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