Search Results - "Mitra, Shamik"
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Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma
Published in Nature communications (23-11-2017)“…Adoptive T-cell therapy (ACT) is a highly intensive immunotherapy regime that has yielded remarkable response rates and many durable responses in clinical…”
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2
Tertiary lymphoid structures improve immunotherapy and survival in melanoma
Published in Nature (London) (23-01-2020)“…Checkpoint blockade therapies that reactivate tumour-associated T cells can induce durable tumour control and result in the long-term survival of patients with…”
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3
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
Published in Nature communications (27-07-2020)“…Homologous recombination deficiency (HRD) is a defining characteristic in BRCA -deficient breast tumors caused by genetic or epigenetic alterations in key…”
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4
Molecular analyses of triple-negative breast cancer in the young and elderly
Published in Breast cancer research : BCR (10-02-2021)“…Breast cancer in young adults has been implicated with a worse outcome. Analyses of genomic traits associated with age have been heterogenous, likely because…”
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Analysis of DNA methylation patterns in the tumor immune microenvironment of metastatic melanoma
Published in Molecular oncology (01-05-2020)“…The presence of immune cells in the tumor microenvironment has been associated with response to immunotherapies across several cancer types, including…”
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Author Correction: Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma
Published in Nature communications (01-04-2020)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Correction to: Molecular analyses of triple-negative breast cancer in the young and elderly
Published in Breast cancer research : BCR (24-02-2021)“…An amendment to this paper has been published and can be accessed via the original article…”
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Improved survival prognostication of node-positive malignant melanoma patients utilizing shotgun proteomics guided by histopathological characterization and genomic data
Published in Scientific reports (26-03-2019)“…Metastatic melanoma is one of the most common deadly cancers, and robust biomarkers are still needed, e.g. to predict survival and treatment efficiency. Here,…”
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MDM2 amplification in rod-shaped chromosomes provides clues to early stages of circularized gene amplification in liposarcoma
Published in Communications biology (20-05-2024)“…Well-differentiated liposarcoma (WDLS) displays amplification of genes on chromosome 12 (Chr12) in supernumerary ring or giant marker chromosomes. These…”
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DNA promoter hypermethylation of melanocyte lineage genes determines melanoma phenotype
Published in JCI insight (10-10-2022)“…Cellular stress contributes to the capacity of melanoma cells to undergo phenotype switching into highly migratory and drug-tolerant dedifferentiated states…”
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Insertion of the CXXC domain of KMT2A into YAP1: An unusual mechanism behind the formation of a chimeric oncogenic protein
Published in Genes chromosomes & cancer (01-11-2023)“…Most neoplasia-associated gene fusions are formed through the fusion of the 5'-part of one gene with the 3'-part of another. We here describe a unique…”
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The Role of PTEN Loss in Immune Escape, Melanoma Prognosis and Therapy Response
Published in Cancers (21-03-2020)“…Checkpoint blockade therapies have changed the clinical management of metastatic melanoma patients considerably, showing survival benefits. Despite the…”
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Transcriptomic profiles of myxofibrosarcoma and undifferentiated pleomorphic sarcoma correlate with clinical and genomic features
Published in The Journal of pathology (01-11-2024)“…Myxofibrosarcoma (MFS) and undifferentiated pleomorphic sarcoma (UPS) are two common and aggressive subtypes of soft tissue sarcoma. The aim of this study was…”
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Tumor genetic heterogeneity analysis of chronic sun‐damaged melanoma
Published in Pigment cell and melanoma research (01-05-2020)“…Chronic sun‐damaged (CSD) melanoma represents 10%–20% of cutaneous melanomas and is characterized by infrequent BRAF V600E mutations and high mutational load…”
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Amplification of ERBB2 (HER2) in embryonal rhabdomyosarcoma: A potential treatment target in rare cases?
Published in Genes chromosomes & cancer (01-01-2022)“…The ERBB2 gene encodes a receptor tyrosine kinase also known as HER2. The gene is amplified and overexpressed in one‐fifth of breast carcinomas; patients with…”
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Molecular analyses of triple-negative breast cancer in the young and elderly (vol 23, 20, 2021)
Published in BREAST CANCER RESEARCH (24-02-2021)Get full text
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Author Correction: Tertiary lymphoid structures improve immunotherapy and survival in melanoma
Published in Nature (London) (01-04-2020)“…An Amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Journal Article