Search Results - "Mitochondrion"

Mitochondria and microbiota dysfunction in COVID-19 pathogenesis by Saleh, Jumana, Peyssonnaux, Carole, Singh, Keshav K, Edeas, Marvin

“…•Mitochondria are the hub of cellular oxidative homeostasis.•Mitochondria are the major source of reactive oxygen species (ROS).•Extracellular mitochondria are…”
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Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling by Wu, Yuanbo, Chen, Meiqiao, Jiang, Jielong

“…Mitochondrial dysfunction is becoming one of the most emerging pathological process in the etiology of neurological disorders. Other common etiologies of the…”
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Thinking outside the nucleus: Mitochondrial DNA copy number in health and disease by Castellani, Christina A., Longchamps, Ryan J., Sun, Jing, Guallar, Eliseo, Arking, Dan E.

“…•mtDNA-CN, a proxy for mitochondrial function, is associated with chronic disease.•mtDNA-CN can be measured from pre-existing microarray and sequencing…”
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Mitochondrial β-oxidation of saturated fatty acids in humans by Adeva-Andany, María M, Carneiro-Freire, Natalia, Seco-Filgueira, Mónica, Fernández-Fernández, Carlos, Mouriño-Bayolo, David

“…Mitochondrial β-oxidation of fatty acids generates acetyl-coA, NADH and FADH . Acyl-coA synthetases catalyze the binding of fatty acids to coenzyme A to form…”
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The rise of mitochondria in medicine by Picard, Martin, Wallace, Douglas C, Burelle, Yan

“…Once considered exclusively the cell's powerhouse, mitochondria are now recognized to perform multiple essential functions beyond energy production, impacting…”
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Mitochondrial dynamics and their potential as a therapeutic target by Whitley, B.N., Engelhart, E.A., Hoppins, S.

“…Mitochondrial dynamics shape the mitochondrial network and contribute to mitochondrial function and quality control. Mitochondrial fusion and division are…”
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Blood mitochondrial DNA copy number: What are we counting? by Picard, Martin

“…•Different cell types contain vastly different numbers of mtDNA copies.•Blood mtDNAcn is confounded by cell type composition and platelet abundance.•mtDNAcn is…”
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Complex IV – The regulatory center of mitochondrial oxidative phosphorylation by Kadenbach, Bernhard

“…•Cytochrome oxidase (COX), the regulatory center of OXPHOS.•“ATP-inhibition” of COX prevents ROS formation.•Stress abolishes inhibition of COX by Ca2+…”
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Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases by Dela Cruz, Charles S, Kang, Min-Jong

“…Inflammation represents a comprehensive host response to external stimuli for the purpose of eliminating the offending agent, minimizing injury to host tissues…”
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Comprehensive review on lactate metabolism in human health by Adeva-Andany, M, López-Ojén, M, Funcasta-Calderón, R, Ameneiros-Rodríguez, E, Donapetry-García, C, Vila-Altesor, M, Rodríguez-Seijas, J

“…Metabolic pathways involved in lactate metabolism are important to understand the physiological response to exercise and the pathogenesis of prevalent diseases…”
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Stress and circulating cell-free mitochondrial DNA: A systematic review of human studies, physiological considerations, and technical recommendations by Trumpff, Caroline, Michelson, Jeremy, Lagranha, Claudia J., Taleon, Veronica, Karan, Kalpita R., Sturm, Gabriel, Lindqvist, Daniel, Fernström, Johan, Moser, Dirk, Kaufman, Brett A., Picard, Martin

“…Cell-free mitochondrial DNA (cf-mtDNA) is a marker of inflammatory disease and a predictor of mortality, but little is known about cf-mtDNA in relation to…”
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Mitochondrial dysfunction and oxidative stress in Alzheimer’s disease, and Parkinson’s disease, Huntington’s disease and Amyotrophic Lateral Sclerosis -An updated review by Alqahtani, Taha, Deore, Sharada L., Kide, Anjali A., Shende, Bhavana A., Sharma, Ritika, Dadarao Chakole, Rita, Nemade, Lalita S., Kishor Kale, Nikita, Borah, Sudarshana, Shrikant Deokar, Savita, Behera, Ashok, Dhawal Bhandari, Divya, Gaikwad, Nikita, Kalam Azad, Abul, Ghosh, Arabinda

“…[Display omitted] •Misfolded proteins cause oxidative damage in the central nervous system.•Early-stage neurodegenerative diseases often display mitochondrial…”
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Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction? by Malik, Afshan N, Czajka, Anna

“…Mitochondrial dysfunction is central to numerous diseases of oxidative stress. Changes in mitochondrial DNA (MtDNA) content, often measured as mitochondrial…”
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Photosynthesis, respiration and growth: A carbon and energy balancing act for alternative oxidase by Vanlerberghe, Greg C., Dahal, Keshav, Alber, Nicole A., Chadee, Avesh

“…•Mitochondrial alternative oxidase lowers the ATP yield of plant respiration.•Alternative oxidase optimizes photosynthetic energy (ATP, NADPH) and carbon…”
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Linking mitochondrial dynamics, cristae remodeling and supercomplex formation: How mitochondrial structure can regulate bioenergetics by Baker, Nicole, Patel, Jeel, Khacho, Mireille

“…The dynamic and fluid nature of mitochondria allows for modifications in mitochondrial shape, connectivity and cristae architecture. The precise balance of…”
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Redox homeostasis, oxidative stress and mitophagy by Garza-Lombó, Carla, Pappa, Aglaia, Panayiotidis, Mihalis I., Franco, Rodrigo

“…•Mitophagy is involved in cellular homeostasis, differentiation and aging.•Mitophagy prevents the accumulation of damaged mitochondria and ROS•A number of…”
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Mitochondria, spermatogenesis, and male infertility – An update by Vertika, Singh, Singh, Keshav K., Rajender, Singh

“…•mtDNA is reduced to 70–80 copies per sperm during spermatogenesis.•Mitochondria are critical to germ cell division, apoptosis and differentiation.•Sperm…”
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Regulation of mitochondrial biogenesis through TFAM-mitochondrial DNA interactions: Useful insights from aging and calorie restriction studies by Picca, Anna, Lezza, Angela Maria Serena

“…Mitochondrial biogenesis is regulated to adapt mitochondrial population to cell energy demands. Mitochondrial transcription factor A (TFAM) performs several…”
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The Oxidative Phosphorylation system of the mitochondria in plants by Braun, Hans-Peter

“…•Oxidative phosphorylation (OXPHOS) and photosynthesis are interdependent in plants.•OXPHOS modes vary along the daily light–dark cycle and diverse stress…”
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Variation in protein gene and intron content among land plant mitogenomes by Mower, Jeffrey P.

“…•Protein gene and intron content is compared among mitogenomes from 46 diverse land plants.•Protein gene content varies substantially among most land plant…”
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