Search Results - "Mitkin, Oleg D"

Synthesis, X-Ray Crystal Structure, Hirshfeld Surface Analysis, and Molecular Docking Study of Novel Hepatitis B (HBV) Inhibitor: 8-Fluoro-5-(4-fluorobenzyl)-3-(2-methoxybenzyl)-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one by Ivashchenko, Aleksandr V., Mitkin, Oleg D., Kravchenko, Dmitry V., Kuznetsova, Irina V., Kovalenko, Sergiy M., Bunyatyan, Natalya D., Langer, Thierry

“…A method for the synthesis of 8-fluoro-5-(4-fluorobenzyl)-3-(2-methoxybenzyl)-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one has been developed and the electronic…”
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Novel One-Pot Synthesis of Methyl 4-Hydroxy-2-thioxo-1,2-dihydroquinoline-3-carboxylate: Synthetic and Crystallographic Studies by Kovalenko, Sergiy M., Drushlyak, Oleksandr G., Konovalova, Irina S., Mariutsa, Illia O., Kravchenko, Dmitry V., Ivachtchenko, Alexandre V., Mitkin, Oleg D.

“…A new suitable method of synthesis of methyl 4-hydroxy-2-thioxo-1,2-dihydroquinoline-3-carboxylate by condensation of methyl 2-isothiocyanatobenzoate and…”
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Synthesis, X-ray crystal structure, Hirshfeld surface analysis, and molecular docking study of novel inhibitor of hepatitis B: methyl 4-fluoro-3-(morpholinosulfonyl)benzo[b]thiophene-2-carboxylate by Ivachtchenko, Alexandre V., Mitkin, Oleg D., Kravchenko, Dmitry V., Kovalenko, Sergiy M., Shishkina, Svitlana V., Bunyatyan, Natalya D., Konovalova, Irina S., Dmitrieva, Irina G., Ivanov, Vladimir V., Langer, Thierry

“…A method of 4-fluoro-3-(morpholinosulfonyl)benzo[b]thiophene-2-carboxylate synthesis has been developed and the electronic and spatial structure of a new…”
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Photoactive Barbiturate Receptors:  An Ultimate Lock-and-Key System in Which the Key Unlocks the Lock by Lakkakula, Suman, Mitkin, Oleg D, Valiulin, Roman A, Kutateladze, Andrei G

“…Conditional photofragmentation is achieved with binary systems incorporating the isophthaloyl bis-aminopyridine barbiturate recognition motif and dithiane- or…”
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Non-rigid Diarylmethyl Analogs of Baloxavir as Cap-Dependent Endonuclease Inhibitors of Influenza Viruses by Ivashchenko, Andrei A, Mitkin, Oleg D, Jones, Jeremy C, Nikitin, Alexander V, Koryakova, Angela G, Ryakhovskiy, Alexey, Karapetian, Ruben N, Kravchenko, Dmitry V, Aladinskiy, Vladimir, Leneva, Irina A, Falynskova, Irina N, Glubokova, Ekaterina A, Govorkova, Elena A, Ivachtchenko, Alexandre V

“…4-Substituted 2,4-dioxobutanoic acids inhibit influenza virus cap-dependent endonuclease (CEN) activity. Baloxavir marboxil, 4, is approved for treating…”
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Synthesis and Structure–Activity Relationship (SAR) of (5,7-Disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as Potent Serotonin 5-HT6 Receptor (5-HT6R) Antagonists by Ivachtchenko, Alexandre V, Golovina, Elena S, Kadieva, Madina G, Kysil, Volodymyr M, Mitkin, Oleg D, Tkachenko, Sergey E, Okun, Ilya M

“…Syntheses, biological evaluation as 5-HT6 receptor (5-HT6R) antagonists, and structure–activity relationships for a series of novel 5,7-disubstituted…”
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Synthesis, inhibitory activity and oral dosing formulation of AV5124, the structural analogue of influenza virus endonuclease inhibitor baloxavir by Ivashchenko, Andrei A, Mitkin, Oleg D, Jones, Jeremy C, Nikitin, Alexander V, Koryakova, Angela G, Karapetian, Ruben N, Kravchenko, Dmitry V, Mochalov, Stephan V, Ryakhovskiy, Alexey A, Aladinskiy, Vladimir, Leneva, Irina A, Falynskova, Irina N, Glubokova, Ekaterina A, Govorkova, Elena A, Ivachtchenko, Alexandre V

“…Abstract Background The development and clinical implementation of the cap-dependent endonuclease (CEN) inhibitor baloxavir marboxil was a breakthrough in…”
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Synthesis, biological evaluation and in silico modeling of novel integrase strand transfer inhibitors (INSTIs) by Ivashchenko, Andrey A., Ivanenkov, Yan A., Koryakova, Angela G., Karapetian, Ruben N., Mitkin, Oleg D., Aladinskiy, Vladimir A., Kravchenko, Dmitry V., Savchuk, Nikolai P., Ivashchenko, Alexander V.

“…Although a relatively wide range of therapeutic options is currently available for the treatment of HIV/AIDS, it is still among the most serious and virulent…”
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Synthesis, biological evaluation and in silico modeling of novel pan-genotypic NS5A inhibitors by Ivashchenko, Andrey A., Ivanenkov, Yan A., Aladinskiy, Vladimir A., Karapetian, Ruben N., Koryakova, Angela G., Ryakhovskiy, Alexey A., Mitkin, Oleg D., Kravchenko, Dmitry V., Savchuk, Nikolai P., Zagribelnyy, Bogdan A., Ivashchenko, Alexander V.

“…[Display omitted] •Novel picomolar pan-genotypic NS5A inhibitors.•Combinatorial synthesis, biological evaluation and in silico modeling.•Lead compound showed…”
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Safety and efficacy of aviandr in patients with generalized anxiety disorder: A multicenter, randomized, double-blind, placebo-controlled, dose-finding, pilot study by Ivashchenko, Andrey A., Morozova, Margarita A., Vostokova, Natalia V., Beniashvily, Allan G., Bukhanovskaya, Olga A., Burminskiy, Denis S., Egorova, Alina N., Gluskina, Lubov Y., Gorchakov, Dmitriy S., Karapetian, Ruben N., Kasimova, Lala N., Kravchenko, Dmitry V., Lepilkina, Taissia A., Merkulova, Elena A., Mitkin, Oleg D., Penchul, Nataliya A., Potanin, Sergey S., Rupchev, George E., Ivachtchenko, Alexandre V.

“…Generalized anxiety disorder (GAD) is associated with an imbalance in the functioning of the stimulating neurotransmitter systems in human's brain. We studied…”
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(3-Phenylsulfonylcycloalkano[e and d]pyrazolo[1,5-a]pyrimidin-2-yl)amines: Potent and Selective Antagonists of the Serotonin 5-HT6 Receptor by Ivachtchenko, Alexandre V, Dmitriev, Dmitri E, Golovina, Elena S, Kadieva, Madina G, Koryakova, Angela G, Kysil, Volodymyr M, Mitkin, Oleg D, Okun, Ilya M, Tkachenko, Sergey E, Vorobiev, Anton A

“…5-HT6 receptors are exclusively localized in the CNS and have high affinity with many psychotropic agents. Though the role of this receptor in many CNS…”
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Design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists by Ivachtchenko, Alexandre V., Ivanenkov, Yan A., Mitkin, Oleg D., Vorobiev, Anton A., Kuznetsova, Irina V., Shevkun, Natalia A., Koryakova, Angela G., Karapetian, Ruben N., Trifelenkov, Andrey S., Kravchenko, Dmitry V., Veselov, Mark S., Chufarova, Nina V.

“…A series of novel highly active androgen receptor (AR) antagonists containing…”
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Novel oral anti-influenza drug candidate AV5080 by Ivachtchenko, Alexandre V, Ivanenkov, Yan A, Mitkin, Oleg D, Yamanushkin, Pavel M, Bichko, Vadim V, Shevkun, Natalia A, Karapetian, Ruben N, Leneva, Irina A, Borisova, Olga V, Veselov, Mark S

“…Development of a novel drug candidate with improved potency against influenza virus neuraminidase compared with currently available therapeutics, and high…”
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Synthesis and SAR of 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines as potent serotonin 5-HT6 receptor antagonists by Ivachtchenko, Alexandre V., Golovina, Elena S., Kadieva, Madina G., Kysil, Volodymyr M., Mitkin, Oleg D., Tkachenko, Sergey E., Okun, Ilya

“…Syntheses of a series of novel 3-sulfonyl-pyrazolo[1,5-a]pyrimidines and their 5-HT6 receptor antagonistic structure–activity relationship are disclosed. The…”
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Antagonists of 5-HT6 receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidines—Synthesis and ‘structure–activity’ relationship by Ivachtchenko, Alexandre V., Golovina, Elena S., Kadieva, Madina G., Kysil, Volodymyr M., Mitkin, Oleg D., Vorobiev, Anton A., Okun, Ilya

“…Synthesis and biological evaluation of a new series of structurally unrestricted and intramolecular hydrogen bond restricted derivatives of…”
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Discovery of Novel Highly Potent Hepatitis C Virus NS5A Inhibitor (AV4025) by Ivachtchenko, Alexandre V, Mitkin, Oleg D, Yamanushkin, Pavel M, Kuznetsova, Irina V, Bulanova, Elena A, Shevkun, Natalia A, Koryakova, Angela G, Karapetian, Ruben N, Bichko, Vadim V, Trifelenkov, Andrey S, Kravchenko, Dmitry V, Vostokova, Natalia V, Veselov, Mark S, Chufarova, Nina V, Ivanenkov, Yan A

“…A series of next in class small-molecule hepatitis C virus (HCV) NS5A inhibitors with picomolar potency containing…”
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Crystal structure, Hirshfeld analysis and a molecular docking study of a new inhibitor of the Hepatitis B virus (HBV): ethyl 5-methyl-1,1-dioxo-2-{[5-(pentan-3-yl)-1,2,4-oxadiazol-3-yl]methyl}-2H-1,2,6-thiadiazine-4-carboxylate by Alexandre V. Ivachtchenko, Sergiy M. Kovalenko, Dmitry V. Kravchenko, Oleg D. Mitkin, Vladimir V. Ivanov, Thierry Langer

“…The title compound, C15H22N4O5S, was prepared via alkylation of 3-(chloromethyl)-5-(pentan-3-yl)-1,2,4-oxadiazole in anhydrous dioxane in the presence of…”
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2-Substituted 5,6-dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines: new series of highly potent and specific serotonin 5-HT6 receptor antagonists by Ivachtchenko, Alexandre V, Golovina, Elena S, Kadieva, Madina G, Koryakova, Angela G, Mitkin, Oleg D, Tkachenko, Sergey E, Kysil, Volodymyr M, Okun, Ilya

“…Syntheses, biological evaluation, and structure-activity relationships for a series of novel 2-substituted…”
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Crystal structure, Hirshfeld analysis and a mol-ecular docking study of a new inhibitor of the Hepatitis B virus (HBV): ethyl 5-methyl-1,1-dioxo-2-{[5-(pentan-3-yl)-1,2,4-oxa-diazol-3-yl]meth-yl}-2H-1,2,6-thia-diazine-4-carboxyl-ate by Ivachtchenko, Alexandre V, Kovalenko, Sergiy M, Kravchenko, Dmitry V, Mitkin, Oleg D, Ivanov, Vladimir V, Langer, Thierry

“…The title compound, C15H22N4O5S, was prepared via alkyl-ation of 3-(chloro-meth-yl)-5-(pentan-3-yl)-1,2,4-oxa-diazole in anhydrous dioxane in the presence of…”
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A novel influenza virus neuraminidase inhibitor AV5027 by Ivachtchenko, Alexandre V., Ivanenkov, Yan A., Mitkin, Oleg D., Yamanushkin, Pavel M., Bichko, Vadim V., Leneva, Irina A., Borisova, Olga V.

“…•Novel small-molecule neuraminidase inhibitors from a combinatorial approach.•One NA inhibitor revealed picomolar potency in enzymatic and cell-based…”
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