Search Results - "Mitkevich, V. A."

Anti-amyloid Therapy of Alzheimer’s Disease: Current State and Prospects by Kozin, S. A., Barykin, E. P., Mitkevich, V. A., Makarov, A. A.

“…Drug development for the treatment of Alzheimer’s disease (AD) has been for a long time focused on agents that were expected to support endogenous β-amyloid…”
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Amyloid-β with isomerized Asp7 cytotoxicity is coupled to protein phosphorylation by Zatsepina, O. G., Kechko, O. I., Mitkevich, V. A., Kozin, S. A., Yurinskaya, M. M., Vinokurov, M. G., Serebryakova, M. V., Rezvykh, A. P., Evgen’ev, M. B., Makarov, A. A.

“…Neuronal dysfunction and loss associated with the accumulation of amyloid-β (Aβ) in the form of extracellular amyloid plaques and hyperphosphorylated tau in…”
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Glutathionylation of Na,K-ATPase Alpha-Subunit Alters Enzyme Conformation and Sensitivity to Trypsinolysis by Dergousova, E. A., Poluektov, Y. M., Klimanova, E. A., Petrushanko, I. Y., Mitkevich, V. A., Makarov, A. A., Lopina, O. D.

“…We found earlier that Na,K-ATPase is purified from duck salt glands in partially glutathionylated state (up to 13 of the 23 cysteine residues of the…”
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Structure and functional studies of the ribonuclease binase Glu43Ala/Phe81Ala mutant by Mitkevich, V. A., Schulga, A. A., Trofimov, A. A., Dorovatovskii, P. V., Goncharuk, D. A., Tkach, E. N., Makarov, A. A., Polyakov, K. M.

“…Ribonuclease from Bacillus intermedius (binase) is a small basic protein with antitumour activity. The three‐dimensional structure of the binase mutant form…”
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Redox Status and Protein Glutathionylation in Binase-Treated HPV16-Positive SiHa Carcinoma Cells by Nadyrova, A. I., Petrushanko, I. Y., Mitkevich, V. A., Ilinskaya, O. N.

“…Human papillomavirus type 16 (HPV16) belongs to viruses of the high-risk type and is associated by overexpression of E6 and E7 oncoproteins, which determine…”
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S-glutathionylation of human glyceraldehyde-3-phosphate dehydrogenase and possible role of Cys152-Cys156 disulfide bridge in the active site of the protein by Barinova, K.V., Serebryakova, M.V., Eldarov, M.A., Kulikova, A.A., Mitkevich, V.A., Muronetz, V.I., Schmalhausen, E.V.

“…We previously showed that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is S-glutathionylated in the presence of H2O2 and GSH. S-glutathionylation was shown…”
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Blood–Brain Barrier Transwell Modeling by Petrovskaya, A. V., Barykin, E. P., Tverskoi, A. M., Varshavskaya, K. B., Mitkevich, V. A., Petrushanko, I. Yu, Makarov, A. A.

“…In vitro blood–brain barrier (BBB) modeling with the use of the brain endothelial cells grown on a transwell membrane is widely used to investigate BBB…”
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Combination of RNase Binase and AKT1/2 Kinase Inhibitor Blocks Two Alternative Survival Pathways in Kasumi-1 Cells by Mitkevich, V. A., Petrushanko, I. Yu, Engelhardt, M. G., Kechko, O. I., Makarov, A. A.

“…Treatment of malignant neoplasms often requires the use of combinations of chemotherapeutic agents. However, in order to select combinations that are effective…”
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Metabolic Stress of Red Blood Cells Induces Hemoglobin Glutathionylation by Zaripov, P. I., Kuleshova, Yu. D., Poluektov, Yu. M., Sidorenko, S. V., Kvan, O. K., Maksimov, G. V., Mitkevich, V. A., Makarov, A. A., Petrushanko, I. Yu

“…—Metabolic stress caused by a lack of glucose significantly affects the state of red blood cells, where glycolysis is the main pathway for the production of…”
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Low-Molecular Thiols as a Factor Improving the Sensitivity of Escherichia coli Mutants with Impaired ADP–Heptose Synthesis to Antibiotics by Seregina, T. A., Petrushanko, I. Yu, Zaripov, P. I., Kuleshova, Yu. D., Lobanov, K. V., Shakulov, R. S., Mitkevich, V. A., Makarov, A. A., Mironov, A. S.

“…—Low molecular-weight thiols as glutathione and cysteine are an important part of the cell’s redox regulation system. Previously, we have shown that…”
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HSP70 protects human neuroblastoma cells from apoptosis and oxidative stress induced by amyloid peptide isoAsp7-Aβ(1–42) by Yurinskaya, M M, Mitkevich, V A, Kozin, S A, Evgen'ev, M B, Makarov, A A, Vinokurov, M G

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Isomerization of Asp7 leads to increased toxic effect of amyloid- beta 42 on human neuronal cells by Mitkevich, V A, Petrushanko, I Y, Yegorov, Y E, Simonenko, O V, Vishnyakova, K S, Kulikova, A A, Tsvetkov, P O, Makarov, A A, Kozin, S A

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X-ray diffraction and biochemical studies of W34F mutant ribonuclease binase by Polyakov, K. M, Goncharuk, D. A, Trofimov, A. A, Safonova, T. N, Mitkevich, V. A, Tkach, E. N, Makarov, A. A, Shulga, A. A

“…The structures of two crystal modifications of the W34F mutant ribonuclease from the bacterium Bacillus intermedius (binase) were solved and refined at 1.7 and…”
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Effects of the H6R and D7H Mutations on the Heparin-Dependent Modulation of Zinc-Induced Aggregation of Amyloid β by Radko, S. P., Khmeleva, S. A., Kiseleva, Y. Y., Kozin, S. A., Mitkevich, V. A., Makarov, A. A.

“…Zinc ions and glycosaminoglycans (GAGs) are found in amyloid deposits and are known to modulate the β-amyloid peptide (Аβ) aggregation, which is thought to be…”
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Direct Molecular Fishing of Zinc-Dependent Protein Partners of Amyloid-beta 1–16 with the Taiwan (D7H) Mutation and Phosphorylated Ser8 Residue by Ershov, P. V., Mezentsev, Yu. V., Yablokov, E. O., Kaluzgskiy, L. A., Ivanov, A. S., Gnuchev, N. V., Mitkevich, V. A., Makarov, A. A., Kozin, S. A.

“…We previously showed that the metal-binding domain 1–16 of intact amyloid-beta (Aβ) is involved in interactions with a number of proteins from the cytosolic…”
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Effects of the H6R and D7H Mutations on the Heparin-Dependent Modulation of Zinc-Induced Aggregation of Amyloid β by Radko, S P, Khmeleva, S A, Kiseleva, Y Y, Kozin, S A, Mitkevich, V A, Makarov, A A

“…Zinc ions and glycosaminoglycans (GAGs) are found in amyloid deposits and are known to modulate the β-amyloid peptide (Aβ) aggregation, which is thought to be…”
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Bacillus pumilus Ribonuclease Inhibits Migration of Human Duodenum Adenocarcinoma HuTu 80 Cells by Zelenikhin, P. V., Ead Mohamed, I. S., Nadyrova, A. I., Sirotkina, A. A., Ulyanova, V. V., Mironova, N. L., Mitkevich, V. A., Makarov, A. A., Zenkova, M. A., Ilinskaya, O. N.

“…Migration of cancer cells from the primary tumor site to nearby tissues is the starting point of the metastatic process. The invasive properties of cells are…”
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Direct Molecular Fishing of Zinc-Dependent Protein Partners of Amyloid-beta 1-16 with the Taiwan (D7H) Mutation and Phosphorylated Ser8 Residue by Ershov, P V, Mezentsev, Yu V, Yablokov, E O, Kaluzgskiy, L A, Ivanov, A S, Gnuchev, N V, Mitkevich, V A, Makarov, A A, Kozin, S A

“…We previously showed that the metal-binding domain 1-16 of intact amyloid-beta (Aβ) is involved in interactions with a number of proteins from the cytosolic…”
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Enalaprilat Inhibits Zinc-Dependent Oligomerization of Metal-Binding Domain of Amyloid-beta Isoforms and Protects Human Neuroblastoma Cells from Toxic Action of these Isoforms by Kozin, S. A., Polshakov, V. I., Mezentsev, Y. V., Ivanov, A. S., Zhokhov, S. S., Yurinskaya, M. M., Vinokurov, M. G., Makarov, A. A., Mitkevich, V. A.

“…Intact amyloid-β peptides (Aβ) may undergo prion-like aggregation when they interact with chemically or structurally modified variants of Aβ present in…”
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Ribonuclease binase decreases destructive changes of the liver and restores its regeneration potential in mouse lung carcinoma model by Sen'kova, A.V., Mironova, N.L., Patutina, O.A., Mitkevich, V.A., Markov, O.V., Petrushanko, I.Y., Burnysheva, K.M., Zenkova, M.A., Makarov, A.A.

“…The successful application of exogenous ribonucleases of different origin to suppress tumor growth allows one to consider them as perspective therapeutics for…”
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