Search Results - "Mitic, L L"

A role for autophagy in the extension of lifespan by dietary restriction in C. elegans by Hansen, Malene, Chandra, Abha, Mitic, Laura L, Onken, Brian, Driscoll, Monica, Kenyon, Cynthia

“…In many organisms, dietary restriction appears to extend lifespan, at least in part, by down-regulating the nutrient-sensor TOR (Target Of Rapamycin). TOR…”
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Molecular architecture of tight junctions by Mitic, L L, Anderson, J M

“…The tight junction creates a regulated barrier in the paracellular pathway and, together with the actin-rich adherens junction, forms a functional unit called…”
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Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut by Rahner, Christoph, Mitic, Laura L., Anderson, James M.

“…Background & Aims: Paracellular transport varies widely among epithelia of the gastrointestinal tract. We determined whether members of the claudin family of…”
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Progranulin: at the interface of neurodegenerative and metabolic diseases by Nguyen, Andrew D, Nguyen, Thi A, Martens, Lauren Herl, Mitic, Laura L, Farese, Robert V

“…Highlights • Progranulin is a secreted glycoprotein found in plasma and CSF. • Progranulin has growth factor-like and inflammation-related properties. •…”
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Claudin-2 Forms Homodimers and Is a Component of a High Molecular Weight Protein Complex by Van Itallie, Christina M., Mitic, Laura L., Anderson, James M.

“…Tight junctions are multiprotein complexes that form the fundamental physiologic and anatomic barrier between epithelial and endothelial cells, yet little…”
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Molecular physiology and pathophysiology of tight junctions I. Tight junction structure and function: lessons from mutant animals and proteins by Mitic, L L, Van Itallie, C M, Anderson, J M

“…Tight junctions form the major paracellular barrier in epithelial tissues. Barrier-sealing properties are quite variable among cell types in terms of…”
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SUMOylation of claudin-2 by Van Itallie, Christina M., Mitic, Laura L., Anderson, James M.

“…The C‐terminal cytoplasmic tails of claudins are likely sites for interaction with proteins that regulate their function. We performed a yeast two‐hybrid…”
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Transmembrane proteins in the tight junction barrier by FANNING, A. S, MITIC, L. L, ANDERSON, J. M

“…Three types of transmembrane proteins have been identified within the tight junction, but it remains to be determined how they provide the molecular basis for…”
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Expression, solubilization, and biochemical characterization of the tight junction transmembrane protein claudin‐4 by Mitic, Laura L., Unger, Vinzenz M., Anderson, James Melvin

“…The tight junction tetraspan protein claudin‐4 creates a charge‐selective pore in the paracellular pathway across epithelia. The structure of the pore is…”
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Connexin-Occludin Chimeras Containing the ZO-Binding Domain of Occludin Localize at MDCK Tight Junctions and NRK Cell Contacts by Mitic, Laura L., Schneeberger, Eveline E., Fanning, Alan S., Anderson, James Melvin

“…Occludin is a transmembrane protein of the tight junction that functions in creating both an intercellular permeability barrier and an intramembrane diffusion…”
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CaCo-2 cells treated with Clostridium perfringens enterotoxin form multiple large complex species, one of which contains the tight junction protein occludin by Singh, U, Van Itallie, C M, Mitic, L L, Anderson, J M, McClane, B A

“…The previous model for the action of Clostridium perfringens enterotoxin (CPE) proposed that (i) CPE binds to host cell receptor(s), forming a small (…”
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Comparative biochemical and immunocytochemical studies reveal differences in the effects of Clostridium perfringens enterotoxin on polarized CaCo-2 cells versus Vero cells by Singh, U, Mitic, L L, Wieckowski, E U, Anderson, J M, McClane, B A

“…Since most in vitro studies exploring the action of Clostridium perfringens enterotoxin (CPE) utilize either Vero or CaCo-2 cells, the current study directly…”
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Occludin localization at the tight junction requires the second extracellular loop by Medina, R, Rahner, C, Mitic, L L, Anderson, J M, Van Itallie, C M

“…Occludin is a transmembrane protein of the tight junction with two extracellular loops. Our previous demonstration that the extracellular loops are adhesive…”
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An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations by Sha, Sharon J., Miller, Zachary A., Min, Sang-won, Zhou, Yungui, Brown, Jesse, Mitic, Laura L., Karydas, Anna, Koestler, Mary, Tsai, Richard, Corbetta-Rastelli, Chiara, Lin, Sophie, Hare, Emma, Fields, Scott, Fleischmann, Kirsten E., Powers, Ryan, Fitch, Ryan, Martens, Lauren Herl, Shamloo, Mehrdad, Fagan, Anne M., Farese, Robert V., Pearlman, Rodney, Seeley, William, Miller, Bruce L., Gan, Li, Boxer, Adam L.

“…Frontotemporal lobar degeneration–causing mutations in the progranulin (GRN) gene reduce progranulin protein (PGRN) levels, suggesting that restoring PGRN in…”
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The role of neurofilament light in genetic frontotemporal lobar degeneration by Zetterberg, Henrik, Teunissen, Charlotte, van Swieten, John, Kuhle, Jens, Boxer, Adam, Rohrer, Jonathan D, Mitic, Laura, Nicholson, Alexandra M, Pearlman, Rodney, McCaughey, Stella Mayo, Tatton, Nadine

“…Abstract Genetic frontotemporal lobar degeneration caused by autosomal dominant gene mutations provides an opportunity for targeted drug development in a…”
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Comparative Biochemical and Immunocytochemical Studies Reveal Differences in the Effects of Clostridium perfringens Enterotoxin on Polarized CaCo-2 CellsVersus Vero Cells by Singh, Usha, Mitic, Laura L., Wieckowski, Eva U., Anderson, James M., McClane, Bruce A.

“…Since most in vitrostudies exploring the action of Clostridium perfringensenterotoxin (CPE) utilize either Vero or CaCo-2 cells, the current study directly…”
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CaCo-2 Cells Treated with Clostridium perfringensEnterotoxin Form Multiple Large Complex Species, One of Which Contains the Tight Junction Protein Occludin by Singh, Usha, Van Itallie, Christina M., Mitic, Laura L., Anderson, James M., McClane, Bruce A.

“…The previous model for the action ofClostridium perfringens enterotoxin (CPE) proposed that (i) CPE binds to host cell receptor(s), forming a small (∼90 kDa)…”
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The Neurofilament Surveillance Project (NSP): A biomarker study to sample blood quarterly in familial frontotemporal lobar degeneration by Acuna‐Narvaez, Rachel, Heuer, Hilary W., Forsberg, Leah K., Alward, Anne, Graham, Danielle, Fishman, Ann, Nelson, Kevin M, Kolander, Tyler, Fillit, Howard M, Galpern, Wendy R, Hung, Serena, Mason, Chris, Mignon, Laurence, Ni, Yan G, Simen, Arthur, Tesseur, Ina, Tsai, Richard, Yeh, Felix L, Mester, Carly T., Ljubenkov, Peter A., Rosen, Howard J., Boeve, Bradley F., Boxer, Adam L., Pearlman, Rodney, Mitic, Laura L

“…Background In familial frontotemporal lobar degeneration (f‐FTLD), plasma levels of neurofilament light (NfL) are elevated at least two years prior to symptom…”
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A Role for Autophagy Genes in the Extension of Lifespan by Dietary Restriction in C. elegans by Hansen, Malene, Chandra, Abha, Mitic, Laura L., Onken, Brian, Driscoll, Monica, Kenyon, Cynthia

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Biosorptive removal of Pb2+, Cd2+ and Zn2+ ions from water by agenaria vulgaris shell by Mitic-Stojanovic, D-L, Zarubica, A, Purenovic, M, Bojic, D, Andjelkovic, T, Bojic, ÀL

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