Search Results - "Mithal, Divakar"

Localized CCR2 Activation in the Bone Marrow Niche Mobilizes Monocytes by Desensitizing CXCR4 by Jung, Hosung, Mithal, Divakar S, Park, Jeong Eun, Miller, Richard J

“…Inflammatory (classical) monocytes residing in the bone marrow must enter the bloodstream in order to combat microbe infection. These monocytes express high…”
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NAD+ Regeneration Rescues Lifespan, but Not Ataxia, in a Mouse Model of Brain Mitochondrial Complex I Dysfunction by McElroy, Gregory S., Reczek, Colleen R., Reyfman, Paul A., Mithal, Divakar S., Horbinski, Craig M., Chandel, Navdeep S.

“…Mitochondrial complex I regenerates NAD+ and proton pumps for TCA cycle function and ATP production, respectively. Mitochondrial complex I dysfunction has been…”
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Factors Associated with Pathway-Concordant Neuroimaging for Pediatric Ischemic Stroke by Gorski, Jillian K., Mithal, Divakar S., Mills, Michele G., Ramgopal, Sriram

“…To determine factors associated with magnetic resonance imaging (MRI) and noninvasive diagnostic angiography among children presenting to the emergency…”
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The Gro3p factor: Restoring NAD+/NADH homeostasis to ameliorate mitochondrial disease by Mithal, Divakar S., Chandel, Navdeep S.

“…Leigh syndrome, a mitochondrial disease, can be modeled in mice with a deficiency in mitochondrial complex I that results in a decreased NAD+/NADH ratio. In…”
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Mitochondrial Dysfunction in Fragile-X Syndrome: Plugging the Leak May Save the Ship by Mithal, Divakar S., Chandel, Navdeep S.

“…Recent work by Licznerski et al. suggests that mutant FMRP linked to Fragile-X syndrome elevates the inner mitochondrial membrane proton leak, leading to…”
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Dexamethasone after early-life seizures attenuates increased susceptibility to seizures, seizure-induced microglia activation and neuronal injury later in life by Fox, Patrick, Mithal, Divakar S., Somogyi, Jason R., Vien, Albert C., Sanchez, Russell M., Koh, Sookyong

“…•KA-SZ in P25 rat increased seizure severity, injury, and activated microglia at P39.•Short course (2-day) dexamethasone after KA-SZ decreased acute microglia…”
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Axonal polyneuropathy and ataxia in children: consider Perrault Syndrome, a case report by Munson, Hannah E, De Simone, Lenika, Schwaede, Abigail, Bhatia, Avanti, Mithal, Divakar S, Young, Nancy, Kuntz, Nancy, Rao, Vamshi K

“…Abstract Background Perrault Syndrome (PRLTS) is a rare, autosomal recessive disorder that presents with bilateral sensorineural hearing loss in all patients…”
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Teaching NeuroImages: Abnormal cervical and cerebral vasculature in 22q11 deletion syndrome by Mithal, Divakar S, Kurz, Jonathan E

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Teaching Neuro Images : Abnormal cervical and cerebral vasculature in 22q11 deletion syndrome by Mithal, Divakar S, Kurz, Jonathan E

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DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting by Yuskaitis, Christopher J., Modasia, Jinita B., Schrötter, Sandra, Rossitto, Leigh-Ana, Groff, Karenna J., Morici, Christopher, Mithal, Divakar S., Chakrabarty, Ram P., Chandel, Navdeep S., Manning, Brendan D., Sahin, Mustafa

“…Caloric restriction and acute fasting are known to reduce seizures but through unclear mechanisms. mTOR signaling has been suggested as a potential mechanism…”
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CXCR4 signaling regulates radial glial morphology and cell fate during embryonic spinal cord development by Mithal, Divakar S., Ren, Dongjun, Miller, Richard J.

“…Embryonic meninges secrete the chemokine SDF‐1/CXCL12 as a chemotactic guide for migrating neural stem cells, but SDF‐1 is not known to directly regulate the…”
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mTORC1 functional assay reveals SZT2 loss-of-function variants and a founder in-frame deletion by Calhoun, Jeffrey D, Aziz, Miriam C, Happ, Hannah C, Gunti, Jonathan, Gleason, Colleen, Mohamed, Najma, Zeng, Kristy, Hiller, Meredith, Bryant, Emily, Mithal, Divakar S, Bellinski, Irena, Kinsley, Lisa, Grimmel, Mona, Schwaibold, Eva M C, Smith-Hicks, Constance, Chassevent, Anna, Scala, Marcello, Accogli, Andrea, Torella, Annalaura, Striano, Pasquale, Capra, Valeria, Bird, Lynne M, Ben-Sahra, Issam, Ekhilevich, Nina, Hershkovitz, Tova, Weiss, Karin, Millichap, John, Gerard, Elizabeth E, Carvill, Gemma L

“…Biallelic pathogenic variants in SZT2 result in a neurodevelopmental disorder with shared features, including early-onset epilepsy, developmental delay,…”
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CXCL12 Signaling in the Development of the Nervous System by Mithal, Divakar S., Banisadr, Ghazal, Miller, Richard J.

“…Chemokines are small, secreted proteins that have been shown to be important regulators of leukocyte trafficking and inflammation. All the known effects of…”
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SDF1 in the dorsal corticospinal tract promotes CXCR4+ cell migration after spinal cord injury by Tysseling, Vicki M, Mithal, Divakar S, Sahni, Vibhu, Birch, Derin, Jung, Hosung, Belmadani, Abdelhak, Miller, Richard J, Kessler, John A

“…Stromal cell-derived factor-1 (SDF1) and its major signaling receptor, CXCR4, were initially described in the immune system; however, they are also expressed…”
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Foxc1 dependent mesenchymal signalling drives embryonic cerebellar growth by Haldipur, Parthiv, Gillies, Gwendolyn S, Janson, Olivia K, Chizhikov, Victor V, Mithal, Divakar S, Miller, Richard J, Millen, Kathleen J

“…Loss of Foxc1 is associated with Dandy-Walker malformation, the most common human cerebellar malformation characterized by cerebellar hypoplasia and an…”
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Treating mitochondrial diseases with antibiotics by Mithal, Divakar S., Chandel, Navdeep S.

“…Mitochondrial diseases are caused by genetic variants in either nuclear or mitochondrial DNA, and they have no known treatments. A new study by Perry et al. in…”
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Fenfluramine: New Treatment for Seizures in Dravet Syndrome by Pierce, Joanna Garcia, Mithal, Divakar S

“…Investigators for the FAiRE DS Study Group assessed the efficacy and safety of Fenfluramine for treating seizures in patients less than 18 y.o. with Dravet…”
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P567: Innovations in education: Empowering child neurology residents with basic concepts in genomic testing through a national curriculum by Sen, Kuntal, Ananth, Amitha, Gottlieb-Smith, Rachel, Calalme, Daniel, Strelzik, Jeffrey, Baranano, Kristin, Emrick, Lisa, Ziobro, Julie, Habela, Christa, Ream, Margie, Mithal, Divakar, Gropman, Andrea, Dang, Louis

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MRI of 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency by Casano, Kelsey R., Ryan, Maura E., Bicknese, Alma R., Mithal, Divakar S.

“…3-Hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency is a rare mitochondrial disorder of valine metabolism which may present with motor delay, hypotonia,…”
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A Promising Small Molecule for Vanishing White Matter Disease by Mithal, Divakar S, Rubin, Jennifer P

“…Investigators from Calico Life Sciences LLC and AbbVie report the effects of a novel drug targeting the genetic basis of Vanishing White Matter Disease (VWMD)…”
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