Search Results - "Mitchison, N A"

T-cell-B-cell cooperation by Mitchison, N. A

“…The discovery that T cells cooperate with B cells in the induction of antibody production marked a milestone in the study of immunology. Together with…”
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J. B. S. Haldane, as I knew him by Mitchison, N. A.

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Aqueous Humor Alloreactive Cell Phenotypes, Cytokines and Chemokines in Corneal Allograft Rejection by Flynn, T. H., Mitchison, N. A., Ono, S. J., Larkin, D. F. P.

“…As biopsies are not taken at the time of human corneal allograft rejection, most information on the early cellular changes in rejection is from animal models…”
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Inflammation at the interface of Innate and Acquired Immunity by Lukic, M.L., Arsenijevic, N., Mitchison, N.A.

“…This is the short summary of the presentation at the 2nd Belgrade Meeting on Immunoregulation entitled “ Inflammation at the interface of Innate and Acquired…”
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Crystal‐ball gazing − the future of immunological research viewed from the cutting edge by Brent, L., Cohen, I. R., Doherty, P. C., Feldmann, M., Matzinger, P., Holgate, S. T., Lachmann, P., Mitchison, N. A., Nossal, G., Rose, N. R., Zinkernagel, R.

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B Cells in Autoimmunity by Mitchison, N. A., Wedderburn, L. R.

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Immunology of Reactive Arthritides by Burmester, G. R, Daser, A, Kamradt, T, Krause, A, Mitchison, N. A, Sieper, J, Wolf, N

“…Reactive arthritis (ReA) and Lyme arthritis together comprise a pair of chronic inflammatory diseases of the joints. Although differing in detail, these…”
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Bystander suppression of murine collagen‐induced arthritis by long‐term nasal administration of a self type II collagen peptide by Bayrak, Ş., Mitchison, N. A.

“…Oral and more recently nasal tolerance have attracted attention as potential treatments of autoimmune disease. Arthritis induced by bovine type II collagen…”
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Specialization, Tolerance, Memory, Competition, Latency, and Strife among T Cells by Mitchison, N. A

“…Over the last four decades much insight has been gained into the working of T cells. This survey offers an interpretation of regulatory T-cell function in…”
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Thalidomide therapy of established collagen‐induced arthritis (CIA) not accompanied by an evident Th2 shift by HAUSCHILD, A., KROEGER, H., MITCHISON, N. A., UGRINOVIC, S., ZWINGENBERGER, K.

“…Thalidomide, a drug likely to affect the cytokine pattern, was administered orally to mice at various stages of CIA. Treatment (150mg/kg per day by gavage, 5…”
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Conditional haploinsufficiency of NCF1 (encoding p47 phox ), a signaling gene with a heterozygous phenotype potentially subject to natural selection by Mitchison, N.A., Harbord, M., Hankin, A., Roes, J.

“…Even a minor degree of haploinsufficiency could eventually reduce the frequency of an autosomal immunodeficiency disease. Searching for such a condition, we…”
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The immunological synapse by Creusot, R.J., Mitchison, N.A., Terazzini, N.M.

“…The immunological synapse plays a central role in organising the immune system. Through their synaptic activity both T and B cells usually, but not always,…”
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Does the polymorphism of MHC class II promoters matter? by Mitchison, N.A., Ono, S.J., Stephens, H.A.

“…The promoters of genes of the major histocompatibility complex vary not only because of linkage disequilibrium with their coding sequences but also, we argue,…”
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Relapsing Arthritis Induced by Cell Transfer from Collagen-Immunised Mice by Hesse, Matthias, Mitchison, Nicholas a.

“…Collagen-induced arthritis is a well-established model of chronic inflammatory arthritis. We here introduce a development of this model which combines the…”
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Genetic variation in the MHC II promoter: lessons for regulation and for comparative genomics by Mitchison, N A

“…Sequence data have been accumulating that reveal variation in gene promoters of the immune system, notably in MHC class II, cytokines and chemokines. The…”
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Type II collagen serology : a guide to clinical responsiveness to oral tolerance ? by GIMSA, U, SIEPER, J, BRAUN, J, MITCHISON, N. A

“…A double-blind placebo-controlled randomized trial of oral collagen type II (CII) treatment in rheumatoid arthritis was completed in Berlin. Anti-CII antibody…”
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Immune suppression genes by OLIVEIRA, D. B. G, MITCHISON, N. A

“…Immune suppression (Is) genes may be defined simple by analogy with immune response (Ir) genes: they are genes which determine whether and to what extent an…”
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Can unresolved infection precipitate autoimmune disease? by Marks, D J B, Mitchison, N A, Segal, A W, Sieper, J

“…Autoimmune diseases are frequently postulated to arise as post-infectious phenomena. Here we survey the evidence supporting these theories, with particular…”
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Where are peptides taking us in T-cell biology? by Mitchison, N A

“…T-cell epitopes are now well understood as amino-acid nonamers binding to major histocompatibility complex molecules. Powerful methods have been developed for…”
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Self/nonself discrimination among immunoregulatory (CD4) T cells by Mitchison, N.A., Katz, D.R., Chain, B.

“…This review covers work on immunological tolerance from 1962 up to the present, focusing on the Th, CD4+compartment of the immune system. The principle…”
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