Search Results - "Mitcheson, John S"

hERG Potassium Channels and the Structural Basis of Drug-Induced Arrhythmias by Mitcheson, John S

“…hERG potassium channels have a critical role in the normal electrical activity of the heart. The block of hERG channels can cause the drug-induced form of long…”
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A mechanism for CO regulation of ion channels by Kapetanaki, Sofia M., Burton, Mark J., Basran, Jaswir, Uragami, Chiasa, Moody, Peter C. E., Mitcheson, John S., Schmid, Ralf, Davies, Noel W., Dorlet, Pierre, Vos, Marten H., Storey, Nina M., Raven, Emma

“…Despite being highly toxic, carbon monoxide (CO) is also an essential intracellular signalling molecule. The mechanisms of CO-dependent cell signalling are…”
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A heme-binding domain controls regulation of ATP-dependent potassium channels by Burton, Mark J., Kapetanaki, Sofia M., Chernova, Tatyana, Jamieson, Andrew G., Dorlet, Pierre, Santolini, Jérôme, Moody, Peter C. E., Mitcheson, John S., Davies, Noel W., Schmid, Ralf, Raven, Emma L., Storey, Nina M.

“…Heme iron has many and varied roles in biology. Most commonly it binds as a prosthetic group to proteins, and it has been widely supposed and amply…”
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Molecular determinants of HERG channel block by Kamiya, Kaichiro, Niwa, Ryoko, Mitcheson, John S, Sanguinetti, Michael C

“…Drug-induced block of cardiac hERG K+ channels causes acquired long QT syndrome. Here, we characterized the molecular mechanism of hERG block by two…”
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hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine by Melgari, Dario, Brack, Kieran E, Zhang, Chuan, Zhang, Yihong, El Harchi, Aziza, Mitcheson, John S, Dempsey, Christopher E, Ng, G André, Hancox, Jules C

“…Ivabradine is a specific bradycardic agent used in coronary artery disease and heart failure, lowering heart rate through inhibition of sinoatrial nodal…”
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A Structural Basis for Drug-Induced Long QT Syndrome by Mitcheson, John S., Chen, Jun, Lin, Monica, Culberson, Chris, Sanguinetti, Michael C.

“…Mutations in the HERG K+channel gene cause inherited long QT syndrome (LQT), a disorder of cardiac repolarization that predisposes affected individuals to…”
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Drug block of the hERG potassium channel: Insight from modeling by Stansfeld, Phillip J., Gedeck, Peter, Gosling, Martin, Cox, Brian, Mitcheson, John S., Sutcliffe, Michael J.

“…Many commonly used, structurally diverse, drugs block the human ether‐a‐go‐go‐related gene (hERG) K+ channel to cause acquired long QT syndrome, which can lead…”
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Author Correction: A mechanism for CO regulation of ion channels by Kapetanaki, Sofia M., Burton, Mark J., Basran, Jaswir, Uragami, Chiasa, Moody, Peter C. E., Mitcheson, John S., Schmid, Ralf, Davies, Noel W., Dorlet, Pierre, Vos, Marten H., Storey, Nina M., Raven, Emma

“…The originally published version of this article contained an error in the subheading ‘Heme is required for CO-dependent channel activation’, which was…”
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Drug binding to HERG channels: evidence for a ‘non‐aromatic’ binding site for fluvoxamine by Mitcheson, John S

“…British Journal of Pharmacology (2003) 139, 883–884. doi:10.1038/sj.bjp.0705336…”
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Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs by Perry, Matthew, Stansfeld, Phillip J, Leaney, Joanne, Wood, Claire, de Groot, Marcel J, Leishman, Derek, Sutcliffe, Michael J, Mitcheson, John S

“…Block of human ether-a-go-go related gene (hERG) K(+) channels by otherwise useful drugs is the most common cause of long QT syndrome, a disorder of cardiac…”
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Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate by Mitcheson, J S, Chen, J, Sanguinetti, M C

“…Deactivation of voltage-gated potassium (K(+)) channels can slow or prevent the recovery from block by charged organic compounds, a phenomenon attributed to…”
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The S4-S5 Linker Couples Voltage Sensing and Activation of Pacemaker Channels by Chen, Jun, Mitcheson, John S., Tristani-Firouzi, Martin, Lin, Monica, Sanguinetti, Michael C.

“…Voltage-gated channels are normally opened by depolarization and closed by repolarization of the membrane. Despite sharing significant sequence homology with…”
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Modulation of hERG potassium channels by a novel small molecule activator by Mitcheson, John S, Hancox, Jules C

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Mechanistic Insight into Human ether-à-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG Domain by Muskett, Frederick W., Thouta, Samrat, Thomson, Steven J., Bowen, Alexander, Stansfeld, Phillip J., Mitcheson, John S.

“…Human ether-à-go-go-related gene (hERG) K+ channels have a critical role in cardiac repolarization. hERG channels close (deactivate) very slowly, and this is…”
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Predicting drug–hERG channel interactions that cause acquired long QT syndrome by Sanguinetti, Michael C., Mitcheson, John S.

“…Avoiding drug-induced cardiac arrhythmia is recognized as a major hurdle in the successful development of new drugs. The most common problem is acquired long…”
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Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel by Burton, Mark J., Cresser-Brown, Joel, Thomas, Morgan, Portolano, Nicola, Basran, Jaswir, Freeman, Samuel L., Kwon, Hanna, Bottrill, Andrew R., Llansola-Portoles, Manuel J., Pascal, Andrew A., Jukes-Jones, Rebekah, Chernova, Tatyana, Schmid, Ralf, Davies, Noel W., Storey, Nina M., Dorlet, Pierre, Moody, Peter C.E., Mitcheson, John S., Raven, Emma L.

“…The EAG (ether-à-go-go) family of voltage-gated K+ channels are important regulators of neuronal and cardiac action potential firing (excitability) and have…”
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A Novel Mechanism for Calmodulin-Dependent Inactivation of Transient Receptor Potential Vanilloid 6 by Bate, Neil, Caves, Rachel E, Skinner, Simon P, Goult, Benjamin T, Basran, Jaswir, Mitcheson, John S, Vuister, Geerten W

“…The paralogues TRPV5 and TRPV6 belong to the vanilloid subfamily of the transient receptor potential (TRP) superfamily of ion channels, and both play an…”
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Correction: Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel by Burton, Mark J., Cresser-Brown, Joel, Thomas, Morgan, Portolano, Nicola, Basran, Jaswir, Freeman, Samuel L., Kwon, Hanna, Bottrill, Andrew R., Llansola-Portoles, Manuel J., Pascal, Andrew A., Jukes-Jones, Rebekah, Chernova, Tatyana, Schmid, Ralf, Davies, Noel W., Storey, Nina M., Dorlet, Pierre, Moody, Peter C.E., Mitcheson, John S., Raven, Emma L.

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New pyrimido-indole compound CD-160130 preferentially inhibits the KV11.1B isoform and produces antileukemic effects without cardiotoxicity by Gasparoli, Luca, D'Amico, Massimo, Masselli, Marika, Pillozzi, Serena, Caves, Rachel, Khuwaileh, Rawan, Tiedke, Wolfgang, Mugridge, Kenneth, Pratesi, Alessandro, Mitcheson, John S, Basso, Giuseppe, Becchetti, Andrea, Arcangeli, Annarosa

“…KV11.1 (hERG1) channels are often overexpressed in human cancers. In leukemias, KV11.1 regulates pro-survival signals that promote resistance to chemotherapy,…”
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Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain by Lörinczi, Eva, Helliwell, Matthew, Finch, Alina, Stansfeld, Phillip J., Davies, Noel W., Mahaut-Smith, Martyn, Muskett, Frederick W., Mitcheson, John S.

“…The ether à go-go family of voltage-gated potassium channels is structurally distinct. The N terminus contains an eag domain (eagD) that contains a…”
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