Search Results - "Mitchell, Todd W."

Advances in mass spectrometry for lipidomics by Blanksby, Stephen J, Mitchell, Todd W

“…Recent expansion in research in the field of lipidomics has been driven by the development of new mass spectrometric tools and protocols for the identification…”
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Differentiation of Complex Lipid Isomers by Radical-Directed Dissociation Mass Spectrometry by Pham, Huong T, Ly, Tony, Trevitt, Adam J, Mitchell, Todd W, Blanksby, Stephen J

“…Contemporary lipidomics protocols are dependent on conventional tandem mass spectrometry for lipid identification. This approach is extremely powerful for…”
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High-Pressure Ozone-Induced Dissociation for Lipid Structure Elucidation on Fast Chromatographic Timescales by Poad, Berwyck L. J, Green, Martin R, Kirk, Jayne M, Tomczyk, Nick, Mitchell, Todd W, Blanksby, Stephen J

“…Ozone-induced dissociation (OzID) is a novel ion activation technology that exploits the gas-phase reaction between mass-selected ions and ozone inside a mass…”
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A Lipidomic Analysis of Placenta in Preeclampsia: Evidence for Lipid Storage by Brown, Simon H J, Eather, Samuel R, Freeman, Dilys J, Meyer, Barbara J, Mitchell, Todd W

“…In preeclampsia, maternal insulin resistance leads to defective expansion of adipocytes, enhanced adipocyte lipolysis, up-regulation of very low density…”
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Characterization of acyl chain position in unsaturated phosphatidylcholines using differential mobility-mass spectrometry[S] by Maccarone, Alan T., Duldig, Jackson, Mitchell, Todd W., Blanksby, Stephen J., Duchoslav, Eva, Campbell, J. Larry

“…Glycerophospholipids (GPs) that differ in the relative position of the two fatty acyl chains on the glycerol backbone (i.e., sn-positional isomers) can have…”
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Structural characterization of glycerophospholipids by combinations of ozone- and collision-induced dissociation mass spectrometry: the next step towards "top-down" lipidomics by Pham, Huong T, Maccarone, Alan T, Thomas, Michael C, Campbell, J Larry, Mitchell, Todd W, Blanksby, Stephen J

“…The complete structural elucidation of complex lipids, including glycerophospholipids, using only mass spectrometry represents a major challenge to…”
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Lipid pathway alterations in Parkinson's disease primary visual cortex by Cheng, Danni, Jenner, Andrew M, Shui, Guanghou, Cheong, Wei Fun, Mitchell, Todd W, Nealon, Jessica R, Kim, Woojin S, McCann, Heather, Wenk, Markus R, Halliday, Glenda M, Garner, Brett

“…We present a lipidomics analysis of human Parkinson's disease tissues. We have focused on the primary visual cortex, a region that is devoid of pathological…”
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Analysis of unsaturated lipids by ozone-induced dissociation by Brown, Simon H.J., Mitchell, Todd W., Blanksby, Stephen J.

“…Recent developments in analytical technologies have driven significant advances in lipid science. The sensitivity and selectivity of modern mass spectrometers…”
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A comparison of patient matched meibum and tear lipidomes by Brown, Simon H J, Kunnen, Carolina M E, Duchoslav, Eva, Dolla, Naveen K, Kelso, Michael J, Papas, Eric B, Lazon de la Jara, Percy, Willcox, Mark D P, Blanksby, Stephen J, Mitchell, Todd W

“…To quantify the molecular lipid composition of patient-matched tear and meibum samples and compare tear and meibum lipid molecular profiles. Lipids were…”
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Ozone-Induced Dissociation:  Elucidation of Double Bond Position within Mass-Selected Lipid Ions by Thomas, Michael C, Mitchell, Todd W, Harman, David G, Deeley, Jane M, Nealon, Jessica R, Blanksby, Stephen J

“…Ions formed from lipids during electrospray ionization of crude lipid extracts have been mass-selected within a quadrupole linear ion trap mass spectrometer…”
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Contrasting metabolic effects of medium- versus long-chain fatty acids in skeletal muscle[S] by Montgomery, Magdalene K., Osborne, Brenna, Brown, Simon H.J., Small, Lewin, Mitchell, Todd W., Cooney, Gregory J., Turner, Nigel

“…Dietary intake of long-chain fatty acids (LCFAs) plays a causative role in insulin resistance and risk of diabetes. Whereas LCFAs promote lipid accumulation…”
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Sequential Collision- and Ozone-Induced Dissociation Enables Assignment of Relative Acyl Chain Position in Triacylglycerols by Marshall, David L, Pham, Huong T, Bhujel, Mahendra, Chin, Jacqueline S. R, Yew, Joanne Y, Mori, Kenji, Mitchell, Todd W, Blanksby, Stephen J

“…Unambiguous identification of isomeric lipids by mass spectrometry represents a significant analytical challenge in contemporary lipidomics. Herein, the…”
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Regulation of mitochondrial metabolism in murine skeletal muscle by the medium‐chain fatty acid receptor Gpr84 by Montgomery, Magdalene K., Osborne, Brenna, Brandon, Amanda E., O'Reilly, Liam, Fiveash, Corrine E., Brown, Simon H. J., Wilkins, Brendan P., Samsudeen, Azrah, Yu, Josephine, Devanapalli, Beena, Hertzog, Ashley, Tolun, Adviye A., Kavanagh, Tomas, Cooper, Antony A., Mitchell, Todd W., Biden, Trevor J., Smith, Nicola J., Cooney, Gregory J., Turner, Nigel

“…Fatty acid receptors have been recognized as important players in glycaemic control. This study is the first to describe a role for the medium‐chain fatty acid…”
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Changes in lipid composition during sexual development of the malaria parasite Plasmodium falciparum by Tran, Phuong N, Brown, Simon H J, Rug, Melanie, Ridgway, Melanie C, Mitchell, Todd W, Maier, Alexander G

“…The development of differentiated sexual stages (gametocytes) within human red blood cells is essential for the propagation of the malaria parasite, since only…”
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Surface analysis of lipids by mass spectrometry: More than just imaging by Ellis, Shane R., Brown, Simon H., in het Panhuis, Marc, Blanksby, Stephen J., Mitchell, Todd W.

“…Mass spectrometry is now an indispensable tool for lipid analysis and is arguably the driving force in the renaissance of lipid research. In its various forms,…”
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Rapid differentiation of isomeric lipids by photodissociation mass spectrometry of fatty acid derivatives by Pham, Huong T., Trevitt, Adam J., Mitchell, Todd W., Blanksby, Stephen J.

“…RATIONALE Both traditional electron ionization and electrospray ionization tandem mass spectrometry have demonstrated limitations in the unambiguous…”
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Cholesteryl ester levels are elevated in the caudate and putamen of Huntington’s disease patients by Phillips, Gabrielle R., Hancock, Sarah E., Brown, Simon H. J., Jenner, Andrew M., Kreilaus, Fabian, Newell, Kelly A., Mitchell, Todd W.

“…Huntington’s disease (HD) is an autosomal dominant neurodegenerative illness caused by a mutation in the huntingtin gene (HTT) and subsequent protein (mhtt),…”
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Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids by Hancock, Sarah E., Ailuri, Ramesh, Marshall, David L., Brown, SimonH.J., Saville, Jennifer T., Narreddula, Venkateswara R., Boase, Nathan R., Poad, BerwyckL.J., Trevitt, Adam J., Willcox, MarkD.P., Kelso, Michael J., Mitchell, Todd W., Blanksby, Stephen J.

“…The (O-acyl)-ω-hydroxy FAs (OAHFAs) comprise an unusual lipid subclass present in the skin, vernix caseosa, and meibomian gland secretions. Although they are…”
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Tau Is Truncated in Five Regions of the Normal Adult Human Brain by Friedrich, Michael G, Skora, Amanda, Hancock, Sarah E, Mitchell, Todd W, Else, Paul L, Truscott, Roger J W

“…The truncation of Tau is thought to be important in promoting aggregation, with this feature characterising the pathology of dementias such as Alzheimer…”
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Human prefrontal cortex phospholipids containing docosahexaenoic acid increase during normal adult aging, whereas those containing arachidonic acid decrease by Norris, Sarah E, Friedrich, Michael G, Mitchell, Todd W, Truscott, Roger J.W, Else, Paul L

“…Abstract Membrane phospholipids make up a substantial portion of the human brain, and changes in their amount and composition are thought to play a role in the…”
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