Search Results - "Mitchell, Stephen N."

Selective action of (−)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268), a group II metabotropic glutamate receptor agonist, on basal and phencyclidine-induced dopamine release in the nucleus accumbens shell by Greenslade, Robert G., Mitchell, Stephen N.

“…The effect of the group II metabotropic receptor agonist (−)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268), on basal and phencyclidine-induced…”
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Fornix deep brain stimulation enhances acetylcholine levels in the hippocampus by Hescham, Sarah, Jahanshahi, Ali, Schweimer, Judith V., Mitchell, Stephen N., Carter, Guy, Blokland, Arjan, Sharp, Trevor, Temel, Yasin

“…Deep brain stimulation (DBS) of the fornix has gained interest as a potential therapy for advanced treatment-resistant dementia, yet the mechanism of action…”
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Synthesis and Pharmacological Characterization of 2‑(2,6-Dichlorophenyl)-1-((1S,3R)‑5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)‑yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor by Hao, Junliang, Beck, James P, Schaus, John M, Krushinski, Joseph H, Chen, Qi, Beadle, Christopher D, Vidal, Paloma, Reinhard, Matthew R, Dressman, Bruce A, Massey, Steven M, Boulet, Serge L, Cohen, Michael P, Watson, Brian M, Tupper, David, Gardinier, Kevin M, Myers, Jason, Johansson, Anette M, Richardson, Jeffery, Richards, Daniel S, Hembre, Erik J, Remick, David M, Coates, David A, Bhardwaj, Rajni M, Diseroad, Benjamin A, Bender, David, Stephenson, Greg, Wolfangel, Craig D, Diaz, Nuria, Getman, Brian G, Wang, Xu-shan, Heinz, Beverly A, Cramer, Jeff W, Zhou, Xin, Maren, Deanna L, Falcone, Julie F, Wright, Rebecca A, Mitchell, Stephen N, Carter, Guy, Yang, Charles R, Bruns, Robert F, Svensson, Kjell A

“…Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. To address…”
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Temporally distinct cognitive effects following acute administration of ketamine and phencyclidine in the rat by Gastambide, Francois, Mitchell, Stephen N, Robbins, Trevor W, Tricklebank, Mark D, Gilmour, Gary

“…Abstract Non-competitive N -methyl- d -aspartate receptor (NMDAR) antagonists such as phencyclidine (PCP) and ketamine are commonly and interchangeably used to…”
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Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders by Bruns, Robert F., Mitchell, Stephen N., Wafford, Keith A., Harper, Alex J., Shanks, Elaine A., Carter, Guy, O'Neill, Michael J., Murray, Tracey K., Eastwood, Brian J., Schaus, John M., Beck, James P., Hao, Junliang, Witkin, Jeffrey M., Li, Xia, Chernet, Eyassu, Katner, Jason S., Wang, Hong, Ryder, John W., Masquelin, Meghane E., Thompson, Linda K., Love, Patrick L., Maren, Deanna L., Falcone, Julie F., Menezes, Michelle M., Zhang, Linli, Yang, Charles R., Svensson, Kjell A.

“…DETQ, an allosteric potentiator of the dopamine D1 receptor, was tested in therapeutic models that were known to respond to D1 agonists. Because of a species…”
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The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig by PULLAR, Ian A, BOOT, John R, BROADMORE, Richard J, EYRE, Tina A, COOPER, Jane, SANGER, Graham J, WEDLEY, Susan, MITCHELL, Stephen N

“…The present study investigated the role of the 5-hydroxytryptamine (5-HT, serotonin)1D receptor as a presynaptic autoreceptor in the guinea pig. In keeping…”
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Electroencephalographic, cognitive, and neurochemical effects of LY3130481 (CERC-611), a selective antagonist of TARP-γ8-associated AMPA receptors by Witkin, Jeffrey M., Li, Jennifer, Gilmour, Gary, Mitchell, Stephen N., Carter, Guy, Gleason, Scott D., Seidel, Wesley F., Eastwood, Brian J., McCarthy, Andrew, Porter, Warren J., Reel, Jon, Gardinier, Kevin M., Kato, Akihiko S., Wafford, Keith A.

“…6-[(1S)-1-[1-[5-(2-hydroxyethoxy)-2-pyridyl]pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one (LY3130481 or CERC-611) is a selective antagonist of AMPA receptors…”
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Investigation of the SSRI augmentation properties of 5-HT2 receptor antagonists using in vivo microdialysis by Boothman, Laura J., Mitchell, Stephen N., Sharp, Trevor

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Mapping the central effects of ketamine in the rat using pharmacological MRI by LITTLEWOOD, Clare L, JONES, Nicholas, O'NEILL, Michael J, MITCHELL, Stephen N, TRICKLEBANK, Mark, WILLIAMS, Steven C. R

“…Ketamine induces, in both humans and rodents, behaviours analogous to some of the symptoms of schizophrenia. To utilise pharmacological magnetic resonance…”
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Biochemical and morphological consequences of human α-synuclein expression in a mouse α-synuclein null background by Prasad, Kavita, Tarasewicz, Elizabeth, Ohman Strickland, Pamela A., O'Neill, Michael, Mitchell, Stephen N., Merchant, Kalpana, Tep, Samnang, Hilton, Kathryn, Datwani, Akash, Buttini, Manuel, Mueller-Steiner, Sarah, Richfield, Eric K.

“…A consensus about the functions of human wild‐type or mutated α‐synuclein (αSYN) is lacking. Both forms of αSYN are implicated in Parkinson’s disease, whereas…”
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Mapping the central effects of ketamine in the rat using pharmacological MRI by Littlewood, Clare L., Jones, Nicholas, O’Neill, Michael J., Mitchell, Stephen N., Tricklebank, Mark, Williams, Steven C. R.

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LY393558, a 5-hydroxytryptamine reuptake inhibitor and 5-HT1B/1D receptor antagonist: effects on extracellular levels of 5-hydroxytryptamine in the guinea pig and rat by MITCHELL, Stephen N, GREENSLADE, Robert G, COOPER, Jane

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Role of muscarinic receptors in the activation of the ventral subiculum and the consequences for dopamine release in the nucleus accumbens by Moss, Sarah, Sharott, Andrew, Goodhead, Lucy H, Mitchell, Stephen N

“…The nucleus accumbens receives limbic inputs from a number of brain regions, including the ventral subiculum. In rats, activation of the ventral subiculum…”
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Activation of the retrohippocampal region in the rat causes dopamine release in the nucleus accumbens: disruption by fornix section by Mitchell, Stephen N, Yee, Ben K, Feldon, Joram, Gray, Jeffrey A, Rawlins, J.Nick P

“…There is a well-described projection from the retrohippocampus (subiculum and entorhinal cortex) to the nucleus accumbens that is involved in the control of…”
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Ventral subiculum administration of the somatostatin receptor agonist MK-678 increases dopamine levels in the nucleus accumbens by Mitchell, Stephen N, Sharrott, Andrew, Cooper, Jane, Greenslade, Robert G

“…Somatostatin (or somatotropin-release inhibitory factor, SRIF) binding and in situ hybridisation studies have indicated a high expression of receptor subtypes…”
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Neurochemical Profile of a Novel Allosteric Potentiator of the Dopamine D1 Receptor by Falcone, Julie F, Mitchell, Stephen N, Carter, Guy, Maren, Deanna L, Katner, Jason, Chernet, Eyassu, Wright, Rebecca A, Wang, Hong, Ryder, John W, Morin, Michelle, Gehlert, Donald R, Johnson, Michael P, Beck, James P, Hao, Junliang, Menezes, Michelle M, Bruns, Robert F, Svensson, Kjell A

“…Abstract only DETQ is a potent and selective dopamine D1 receptor potentiator that is active in several behavioral models (see abstracts by Heinz et al and…”
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Biochemical and morphological consequences of human α-synuclein expression in a mouse α-synuclein null background: Human α-synuclein congenic mice by Prasad, Kavita, Tarasewicz, Elizabeth, Ohman Strickland, Pamela A., O’Neill, Michael, Mitchell, Stephen N., Merchant, Kalpana, Tep, Samnang, Hilton, Kathryn, Datwani, Akash, Buttini, Manuel, Mueller-Steiner, Sarah, Richfield, Eric K.

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Investigation of the SSRI augmentation properties of 5-HT(2) receptor antagonists using in vivo microdialysis by Boothman, Laura J, Mitchell, Stephen N, Sharp, Trevor

“…Recent evidence that 5-HT(2) receptors exert a negative influence on central 5-hydroxytryptamine (5-HT) neurones suggests that 5-HT(2) receptor antagonists may…”
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Investigation of the SSRI augmentation properties of 5-HT 2 receptor antagonists using in vivo microdialysis by Boothman, Laura J., Mitchell, Stephen N., Sharp, Trevor

“…Recent evidence that 5-HT 2 receptors exert a negative influence on central 5-hydroxytryptamine (5-HT) neurones suggests that 5-HT 2 receptor antagonists may…”
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Investigation of the SSRI augmentation properties of 5-HT sub(2) receptor antagonists using in vivo microdialysis by Boothman, Laura J, Mitchell, Stephen N, Sharp, Trevor

“…Recent evidence that 5-HT sub(2) receptors exert a negative influence on central 5-hydroxytryptamine (5-HT) neurones suggests that 5-HT sub(2) receptor…”
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