Search Results - "Mitchell, S.N."

Comparative Effects of LY3020371, a Potent and Selective Metabotropic Glutamate (mGlu) 2/3 Receptor Antagonist, and Ketamine, a Noncompetitive N -Methyl-d-Aspartate Receptor Antagonist in Rodents: Evidence Supporting the Use of mGlu2/3 Antagonists, for the Treatment of Depression by Witkin, J M, Mitchell, S N, Wafford, K A, Carter, G, Gilmour, G, Li, J, Eastwood, B J, Overshiner, C, Li, X, Rorick-Kehn, L, Rasmussen, K, Anderson, W H, Nikolayev, A, Tolstikov, V V, Kuo, M-S, Catlow, J T, Li, R, Smith, S C, Mitch, C H, Ornstein, P L, Swanson, S, Monn, J A

“…The ability of the -methyl-d-aspartate receptor antagonist ketamine to alleviate symptoms in patients suffering from treatment-resistant depression (TRD) is…”
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Modulation of dopamine release in the nucleus accumbens by 5-HT1B agonists: involvement of the hippocampo-accumbens pathway by Boulenguez, P, Rawlins, J.N.P, Chauveau, J, Joseph, M.H, Mitchell, S.N, Gray, J.A

“…Changes in extracellular levels of dopamine (DA), DA metabolites DOPAC and HVA, and the serotonin metabolite 5-HIAA, were measured by microdialysis in the rat…”
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Allosteric modulation of the muscarinic M₄ receptor as an approach to treating schizophrenia by Chan, W.Y, McKinzie, D.L, Bose, S, Mitchell, S.N, Witkin, J.M, Thompson, R.C, Christopoulos, A, Lazareno, S, Birdsall, N.J.M, Bymaster, F.P, Felder, C.C

“…Current antipsychotics provide symptomatic relief for patients suffering from schizophrenia and related psychoses; however, their effectiveness is variable and…”
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Chronic pre-treatment with nicotine enhances nicotine-evoked striatal dopamine release and α6 and β3 nicotinic acetylcholine receptor subunit mRNA in the substantia nigra pars compacta of the rat by Visanji, N.P., Mitchell, S.N., O'Neill, M.J., Duty, S.

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Behavioural and neurochemical responses evoked by repeated exposure to an elevated open platform by Storey, J.D., Robertson, D.A.F., Beattie, J.E., Reid, I.C., Mitchell, S.N., Balfour, D.J.K.

“…Increased psychophysiological resistance to chronic stress has been related to increased 5-HT release in the dorsal hippocampus. This study investigated the…”
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Chronic pre-treatment with nicotine enhances nicotine-evoked striatal dopamine release and α 6 and β 3 nicotinic acetylcholine receptor subunit mRNA in the substantia nigra pars compacta of the rat by Visanji, N.P., Mitchell, S.N., O'Neill, M.J., Duty, S.

“…Whilst local intrastriatal infusion of nicotine consistently elicits striatal dopamine release, systemic administration often fails to do so. Since chronic…”
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Benzothienyloxy phenylpropanamines, novel dual inhibitors of serotonin and norepinephrine reuptake by BOOT, J. R, BRACE, G, RATHMELL, R. E, RICHARDS, S. J, SIMMONDS, R. G, WALLACE, L, WHATTON, M. A, DELATOUR, C. L, DEZUTTER, N, FAIRHURST, J, FINDLAY, J, GALLAGHER, P. T, HOES, I, MAHADEVAN, S, MITCHELL, S. N

“…A series of benzothienyloxy propylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake…”
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Role of the locus coeruleus in the noradrenergic response to a systemic administration of nicotine by Mitchell, S N

“…Experiments were conducted using in vivo microdialysis to ascertain the role of nicotinic receptors in the terminal, or the cell body area, in the hippocampal…”
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N-Alkyl-N-arylmethylpiperidin-4-amines: Novel dual inhibitors of serotonin and norepinephrine reuptake by Boot, J.R., Boulet, S.L., Clark, B.P., Cases-Thomas, M.J., Delhaye, L., Diker, K., Fairhurst, J., Findlay, J., Gallagher, P.T., Gilmore, J., Harris, J.R., Masters, J.J., Mitchell, S.N., Naik, M., Simmonds, R.G., Smith, S.M., Richards, S.J., Timms, G.H., Whatton, M.A., Wolfe, C.N., Wood, V.A.

“…A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. A…”
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Acute administration of nicotine increases the in vivo extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid and ascorbic acid preferentially in the nucleus accumbens of the rat: comparison with caudate-putamen by Brazell, M P, Mitchell, S N, Joseph, M H, Gray, J A

“…Using in vivo dialysis and voltammetry, the effect of acute administration of (-)-nicotine (0.8 mg/kg free base, s.c.) on extracellular levels of dopamine,…”
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Effect of acute administration of nicotine on in vivo release of noradrenaline in the hippocampus of freely moving rats: a dose-response and antagonist study by Brazell, M P, Mitchell, S N, Gray, J A

“…The effect of systemic administration of (-)-nicotine on release of noradrenaline in the hippocampus was studied by in vivo microdialysis in freely moving…”
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The effects of cholinergic drugs and cholinergic-rich foetal neural transplants on alcohol-induced deficits in radial maze performance in rats by Hodges, H, Allen, Y, Sinden, J, Mitchell, S N, Arendt, T, Lantos, P L, Gray, J A

“…Chronic alcohol (20% v/v in drinking water for 28 weeks) impaired acquisition of radial maze spatial and associative tasks by increasing both within-trial…”
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Recent developments in metabotropic glutamate receptors as novel drug targets by O´Neil, M.J., Fell, M.J., Svensson, K.A., Witkin, J.M., Mitchell, S.N.

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Increases in tyrosine hydroxylase messenger RNA in the locus coeruleus after a single dose of nicotine are followed by time-dependent increases in enzyme activity and noradrenaline release by Mitchell, S N, Smith, K M, Joseph, M H, Gray, J A

“…We have utilized biochemical, molecular biological, and functional neurochemical measurements to investigate the integrated and long-term effects of a single…”
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Dopamine release in the nucleus accumbens and latent inhibition in the rat following microinjections of a 5-HT1B agonist into the dorsal subiculum: implications for schizophrenia by Boulenguez, P, Peters, S L, Mitchell, S N, Chauveau, J, Gray, J A, Joseph, M H

“…Microinjection of a serotonergic 5-HT1B agonist (S-CM-GTNH2, 3 microg/l) into the dorsal subiculum (DS) induced long-lasting increases in dopamine (DA; +58%),…”
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The effect of progesterone and human interferon alpha-2 on the release of PGF2 alpha and PGE from epithelial cells of human proliferative endometrium by Mitchell, S N, Smith, S K

“…Progesterone and interferon-like trophoblastic proteins modulate prostaglandin (PG) synthesis from endometrium in early ovine and bovine pregnancy. Enriched…”
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