Search Results - "Mitchell, Naomi"

Psi promotes Drosophila wing growth via direct transcriptional activation of cell cycle targets and repression of growth inhibitors by Zaytseva, Olga, Mitchell, Naomi C, Muckle, Damien, Delandre, Caroline, Nie, Zuqin, Werner, Janis K, Lis, John T, Eyras, Eduardo, Hannan, Ross D, Levens, David L, Marshall, Owen J, Quinn, Leonie M

“…The first characterised FUSE Binding Protein family member, FUBP1, binds single-stranded DNA to activate MYC transcription. Psi, the sole FUBP protein in…”
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Transcriptional repression of Myc underlies the tumour suppressor function of AGO1 in Drosophila by Zaytseva, Olga, Mitchell, Naomi C, Guo, Linna, Marshall, Owen J, Parsons, Linda M, Hannan, Ross D, Levens, David L, Quinn, Leonie M

“…Here, we report novel tumour suppressor activity for the Argonaute family RNA-binding protein AGO1, a component of the miRNA-dependent RNA-induced silencing…”
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An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration by Periasamy, Agalya, Mitchell, Naomi, Zaytseva, Olga, Chahal, Arjun S., Zhao, Jiamin, Colman, Peter M., Quinn, Leonie M., Gulbis, Jacqueline M.

“…Intronic polymorphic TOMM40 variants increasing TOMM40 mRNA expression are strongly correlated to late onset Alzheimer’s Disease. The gene product, hTomm40,…”
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Drosophila ribosomal protein mutants control tissue growth non-autonomously via effects on the prothoracic gland and ecdysone by Lin, Jane I, Mitchell, Naomi C, Kalcina, Marina, Tchoubrieva, Elly, Stewart, Mary J, Marygold, Steven J, Walker, Cherryl D, Thomas, George, Leevers, Sally J, Pearson, Richard B, Quinn, Leonie M, Hannan, Ross D

“…The ribosome is critical for all aspects of cell growth due to its essential role in protein synthesis. Paradoxically, many Ribosomal proteins (Rps) act as…”
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Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth by Guo, Linna, Zaysteva, Olga, Nie, Zuqin, Mitchell, Naomi C, Amanda Lee, Jue Er, Ware, Thomas, Parsons, Linda, Luwor, Rodney, Poortinga, Gretchen, Hannan, Ross D, Levens, David L, Quinn, Leonie M

“…Despite two decades of research, the major function of FBP-family KH domain proteins during animal development remains controversial. The literature is divided…”
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The Ecdysone-inducible zinc-finger transcription factor Crol regulates Wg transcription and cell cycle progression in Drosophila by Mitchell, Naomi, Cranna, Nicola, Richardson, Helena, Quinn, Leonie

“…The steroid hormone Ecdysone is crucial for developmental cell death, proliferation and morphogenesis in Drosophila . Herein, we delineate a molecular pathway…”
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The novel zinc finger protein dASCIZ regulates mitosis in Drosophila via an essential role in dynein light-chain expression by Zaytseva, Olga, Tenis, Nora, Mitchell, Naomi, Kanno, Shin-ichiro, Yasui, Akira, Heierhorst, Jörg, Quinn, Leonie M

“…The essential zinc finger protein ASCIZ (also known as ATMIN, ZNF822) plays critical roles during lung organogenesis and B cell development in mice, where it…”
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Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth by Lim, Nicholas R., Shohayeb, Belal, Zaytseva, Olga, Mitchell, Naomi, Millard, S. Sean, Ng, Dominic C.H., Quinn, Leonie M.

“…The second most commonly mutated gene in primary microcephaly (MCPH) patients is wd40-repeat protein 62 (wdr62), but the relative contribution of WDR62…”
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S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila by Mitchell, Naomi C., Tchoubrieva, Elissaveta B., Chahal, Arjun, Woods, Simone, Lee, Amanda, Lin, Jane I., Parsons, Linda, Jastrzebski, Katarzyna, Poortinga, Gretchen, Hannan, Katherine M., Pearson, Richard B., Hannan, Ross D., Quinn, Leonie M.

“…Increased rates of ribosome biogenesis and biomass accumulation are fundamental properties of rapidly growing and dividing malignant cells. The MYC oncoprotein…”
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Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models by Lee, Jue Er Amanda, Mitchell, Naomi C., Zaytseva, Olga, Chahal, Arjun, Mendis, Peter, Cartier-Michaud, Amandine, Parsons, Linda M., Poortinga, Gretchen, Levens, David L., Hannan, Ross D., Quinn, Leonie M.

“…Nucleotide excision DNA repair (NER) pathway mutations cause neurodegenerative and progeroid disorders (xeroderma pigmentosum (XP), Cockayne syndrome (CS) and…”
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The Ecdysone receptor constrains wingless expression to pattern cell cycle across the Drosophila wing margin in a Cyclin B-dependent manner by Mitchell, Naomi C, Lin, Jane I, Zaytseva, Olga, Cranna, Nicola, Lee, Amanda, Quinn, Leonie M

“…Ecdysone triggers transcriptional changes via the ecdysone receptor (EcR) to coordinate developmental programs of apoptosis, cell cycle and differentiation…”
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Hfp inhibits Drosophila myc transcription and cell growth in a TFIIH/Hay-dependent manner by Mitchell, Naomi C, Johanson, Timothy M, Cranna, Nicola J, Er, Amanda Lee Jue, Richardson, Helena E, Hannan, Ross D, Quinn, Leonie M

“…An unresolved question regarding the RNA-recognition motif (RRM) protein Half pint (Hfp) has been whether its tumour suppressor behaviour occurs by a…”
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Hfp, the Drosophila homolog of the mammalian c-myc transcriptional-repressor and tumor suppressor FIR, inhibits dmyc transcription and cell growth by Cranna, Nicola J., Mitchell, Naomi C., Hannan, Ross D., Quinn, Leonie M.

“…Here we highlight our recent study, which revealed a mechanism critical for tight regulation of Drosophila myc (dmyc) transcription. Our previous work…”
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Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC by Shohayeb, Belal, Mitchell, Naomi, Millard, S. Sean, Quinn, Leonie M., Ng, Dominic C.H.

“…WD40-Repeat Protein 62 (WDR62) is required to maintain neural and glial cell populations during embryonic brain growth. Although elevated expression of WDR62…”
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Conversational Language in 3-Year-Old Children Born Very Preterm and at Term by Sanchez, Katherine, Spittle, Alicia J, Boyce, Jessica O, Leembruggen, Linda, Mantelos, Anastasia, Mills, Stephanie, Mitchell, Naomi, Neil, Emily, St John, Miya, Treloar, Jasmin, Morgan, Angela T

“…Purpose: Language difficulties are prevalent among children born preterm. Existing studies have largely used standardized language tests, providing limited…”
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Cultivating Healthy Marriages: The Juxtaposition of Preaching and Pastoral Care in a Retreat Setting by Mitchell, Naomi Annetta

“…This project focuses on the role of the delivery of pastoral care during the preaching moment as a means of cultivating, facilitating, and strengthening…”
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A Rural Clinical Placement: Children's Outcomes by Dodd, Barbara, Castles, Johanna, Aar, Melissa, Hally, Vanessa, McKimmie, Jane, Mitchell, Naomi, Tibbetts, Stuart, Wong, Michelle, Keage, Meg

“…Evaluations of speech-language pathology (SLP) students' learning in rural and remote clinical placements are positive, but treatment outcomes for children…”
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The Ecdysone receptor constrains wingless expression to pattern cell cycle across the Drosophilawing margin in a cyclin B-dependent manner by Mitchell, Naomi C, Lin, Jane I, Zaytseva, Olga, Cranna, Nicola, Lee, Amanda, Quinn, Leonie M

“…Abstract Background Ecdysone triggers transcriptional changes via the ecdysone receptor (EcR) to coordinate developmental programs of apoptosis, cell cycle and…”
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Drosophila Ribosomal Protein Mutants Control Tissue Growth Non-Autonomously via Effects on the Prothoracic Gland and Ecdysone: e1002408 by Lin, Jane I, Mitchell, Naomi C, Kalcina, Marina, Tchoubrieva, Elly, Stewart, Mary J, Marygold, Steven J, Walker, Cherryl D, Thomas, George, Leevers, Sally J, Pearson, Richard B, Quinn, Leonie M, Hannan, Ross D

“…The ribosome is critical for all aspects of cell growth due to its essential role in protein synthesis. Paradoxically, many Ribosomal proteins (Rps) act as…”
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Abstract 2762: Spatial proteomics of lung adenocarcinoma mouse models with divergent propensities for metastasis by Ramkissoon, Paige, Mitchell-Hutchinson, Naomi, Wells, Julie, Maser, Rick, Stodola, Tim, Hoffmann, Brian, Marchini, Anne, Bechtel, Elaine, Doty, Rosalinda, Bult, Carol J.

“…Abstract Introduction: Lung cancer is the leading cause of cancer deaths worldwide with most deaths attributed to metastasis. Metastases in existing mouse…”
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