Search Results - "Mitchell, Mark B"

An Enyne Cycloisomerization Approach to the Triple Reuptake Inhibitor GSK1360707F by Deschamps, Nicole M, Elitzin, Vassil I, Liu, Bing, Mitchell, Mark B, Sharp, Matthew J, Tabet, Elie A

“…The triple reuptake inhibitor GSK1360707F was synthesized via an efficient and scalable route that features an enyne cycloisomerization reaction catalyzed by…”
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Optimization and Scale-Up of a Suzuki−Miyaura Coupling Reaction: Development of an Efficient Palladium Removal Technique by Bullock, Kae M, Mitchell, Mark B, Toczko, Jennifer F

“…A ligand−solvent−base screen was performed on a Suzuki−Miyaura coupling reaction, and the screening data, followed by a set of focused experiments, helped to…”
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Concise Synthesis, Preparative Resolution, Absolute Configuration Determination, and Applications of an Atropisomeric Biaryl Catalyst for Asymmetric Acylation by Spivey, Alan C, Zhu, Fujiang, Mitchell, Mark B, Davey, Stephen G, Jarvest, Richard L

“…A new three-step synthesis and resolution of nucleophilic catalyst 1 suitable for large-scale preparation has been developed, and this catalyst has been shown…”
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Highly Selective Primary Alkoxycarboxylation and Esterification of Unprotected Pyranose Derivatives Mediated by Scandium(III) Triflate Catalysis by McClure, Michael S., Berry, Malcolm B., Caine, Darren, Crawford, Claire, Crump, Brian C., Glover, Bobby N., Kedia, Sandeep B., Millar, Alan, Mitchell, Mark B., Nichols, Christopher J., Patterson, Daniel E., Powers, Jeremiah

“…A highly selective method for the alkoxycarboxylation and acylation of primary alcohols of pyranose derivatives is described. The reaction is high yielding and…”
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Metal–Organic Framework- and Polyoxometalate-Based Sorbents for the Uptake and Destruction of Chemical Warfare Agents by Grissom, Tyler G, Plonka, Anna M, Sharp, Conor H, Ebrahim, Amani M, Tian, Yiyao, Collins-Wildman, Daniel L, Kaledin, Alexey L, Siegal, Harrison J, Troya, Diego, Hill, Craig L, Frenkel, Anatoly I, Musaev, Djamaladdin G, Gordon, Wesley O, Karwacki, Christopher J, Mitchell, Mark B, Morris, John R

“…The threat of chemical warfare agents (CWAs), assured by their ease of synthesis and effectiveness as a terrorizing weapon, will persist long after the…”
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Effect of Carbon Dioxide on the Degradation of Chemical Warfare Agent Simulant in the Presence of Zr Metal Organic Framework MOF-808 by Plonka, Anna M, Grissom, Tyler G, Musaev, Djamaladdin G, Balboa, Alex, Gordon, Wesley O, Collins-Wildman, Daniel L, Ghose, Sanjit K, Tian, Yiyao, Ebrahim, Amani M, Mitchell, Mark B, Hill, Craig L, Morris, John R, Frenkel, Anatoly I

“…Developing novel and more efficient filters for chemical warfare agent (CWA) decomposition remains an important challenge for modern technology due to the…”
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Adsorption and Decomposition of Dimethyl Methylphosphonate on Metal Oxides by Mitchell, Mark B, Sheinker, V. N, Mintz, Eric A

“…The adsorption and decomposition of dimethyl methylphosphonate (DMMP) have been examined on four different metal oxide surfaces:  aluminum oxide, magnesium…”
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Copper-Catalyzed Asymmetric Hydrogenation of Aryl and Heteroaryl Ketones by Krabbe, Scott W, Hatcher, Mark A, Bowman, Roy K, Mitchell, Mark B, McClure, Michael S, Johnson, Jeffrey S

“…High throughput screening enabled the development of a Cu-based catalyst system for the asymmetric hydrogenation of prochiral aryl and heteroaryl ketones that…”
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Correlated Multimodal Approach Reveals Key Details of Nerve-Agent Decomposition by Single-Site Zr-Based Polyoxometalates by Tian, Yiyao, Plonka, Anna M, Ebrahim, Amani M, Palomino, Robert M, Senanayake, Sanjaya D, Balboa, Alex, Gordon, Wesley O, Troya, Diego, Musaev, Djamaladdin G, Morris, John R, Mitchell, Mark B, Collins-Wildman, Daniel L, Hill, Craig L, Frenkel, Anatoly I

“…Development of technologies for protection against chemical warfare agents (CWAs) is critically important. Recently, polyoxometalates have attracted attention…”
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Polymorph and Particle Size Control of PPAR Compounds PF00287586 and AG035029 by Kline, Billie J, Saenz, James, Stanković, Nebojša, Mitchell, Mark B

“…Development of polymorph control procedures for PF00287586 and AG035029 is described herein. For PF00287586, investigations were undertaken to control…”
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Homeward bound: the safety of discharging postappendectomy patients directly home from the recovery room by Mitchell, Mark B, Daniel, Dale

“…The discharge of the patients directly from the recovery room after appendectomy has only recently been described in the literature. Because the 30-day…”
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Enzymatic- and iridium-catalyzed asymmetric synthesis of a benzothiazepinylphosphonate bile acid transporter inhibitor by Cowan, David J, Collins, Jon L, Mitchell, Mark B, Ray, John A, Sutton, Peter W, Sarjeant, Amy A, Boros, Eric E

“…A synthesis of the benzothiazepine phosphonic acid 3, employing both enzymatic and transition metal catalysis, is described. The quaternary chiral center of 3…”
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Synthesis of HCV Replicase Inhibitors: Base-Catalyzed Synthesis of Protected α‑Hydrazino Esters and Selective Aerobic Oxidation with Catalytic Pt/Bi/C for Synthesis of Imidazole-4,5-dicarbaldehyde by Bowman, Roy K, Brown, Andrew D, Cobb, Jannine H, Eaddy, John F, Hatcher, Mark A, Leivers, Martin R, Miller, John F, Mitchell, Mark B, Patterson, Daniel E, Toczko, Matthew A, Xie, Shiping

“…A robust convergent synthesis of the prodrugs of HCV replicase inhibitors 1–5 is described. The central 5H-imidazo[4,5-d]pyridazine core was formed from…”
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Reaction Progress Analysis: Powerful Tool for Understanding Suzuki−Miyaura Reaction and Control of Polychlorobiphenyl Impurity by Kedia, Sandeep B, Mitchell, Mark B

“…Cross coupling of unsaturated aryl or vinyl triflates/halides with aryl boronic acids using Pd as catalyst (Suzuki coupling) have become increasingly…”
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Development of Large-Scale Routes to Potent GPR119 Receptor Agonists by Matsuoka, Richard T, Boros, Eric E, Brown, Andrew D, Bullock, Kae M, Canoy, Will L, Carpenter, Andrew J, Cobb, Jeremy D, Condon, Shannon E, Deschamps, Nicole M, Elitzin, Vassil I, Erickson, Greg, Fang, Jing M, Igo, David H, Joshi, Biren K, Kaldor, Istvan W, Mitchell, Mark B, Peckham, Gregory E, Reynolds, Daniel W, Salmon, Matthew C, Sharp, Matthew J, Tabet, Elie A, Toczko, Jennifer F, Wu, Lianming Michael, Zhou, Xiao-ming M

“…Practical and scalable syntheses were developed that were used to prepare multikilogram batches of GSK1292263A (1) and GSK2041706A (15), two potent G…”
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Room Temperature Reaction of Ozone and Dimethyl Methylphosphonate (DMMP) on Alumina-Supported Iron Oxide by Mitchell, Mark B, Sheinker, Viktor N, Cox, Woodrow W

“…The reaction of dimethyl methylphosphonate (DMMP) with ozone on a reactive adsorbent, alumina-supported iron oxide, has been examined at room temperature. The…”
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Preparation and characterization of supported mononuclear metal complexes as model catalysts by Kenvin, Jeffrey C, White, Mark G, Mitchell, Mark B

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Expedited Development through Parallel Reaction Screening: Application to PTC-Mediated Knoevenagel Condensation by Corona, John A, Davis, Roman D, Kedia, Sandeep B, Mitchell, Mark B

“…Parallel microreactor screening enabled rapid identification of effective conditions for PTC-mediated Knoevenagel condensation between aldehyde (1) and…”
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Quantitative Study of the Decomposition of Dimethyl Methylphosphonate (DMMP) on Metal Oxides at Room Temperature and Above by Sheinker, Viktor N, Mitchell, Mark B

“…The adsorption and decomposition reactions of dimethyl methylphosphonate (DMMP) on a commercial γ-Al2O3, a γ-Al2O3-supported iron oxide, and a sol−gel-prepared…”
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The Co−CH3 Bond in Imine/Oxime B12 Models. Influence of the Orientation and Donor Properties of the trans Ligand As Assessed by FT-Raman Spectroscopy by Hirota, Shun, Polson, Suzette M, Puckett, James M, Moore, Scott J, Mitchell, Mark B, Marzilli, Luigi G

“…Near-IR FT-Raman spectroscopy was used to probe the properties of three types of methyl imine/oxime B12 model compounds in CHCl3 solution. These types differ…”
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