Search Results - "Mitchell, Jolyon P."

Interchanging Reusable and Disposable Nebulizers Used with Home-Based Compressors May Result in Inconsistent Dosing: A Laboratory Investigation with Device Combinations Supplied to the US Healthcare Environment by Schloss, Judy, Coppolo, Dominic P., Suggett, Jason A., Nagel, Mark W., Mitchell, Jolyon P.

“…Introduction Reusable nebulizer–compressor combinations deliver inhaled medications for patients with chronic lung diseases. On hospital discharge, the patient…”
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Particle Size Measurements from Orally Inhaled and Nasal Drug Products by Mitchell, Jolyon P

“…Particle size measurement of aerosolized particles from orally inhaled and nasal drug products (OINDPs) can be used to assess the likely deposition…”
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Improved Quality Control Metrics for Cascade Impaction Measurements of Orally Inhaled Drug Products (OIPs) by Tougas, Terrence P., Christopher, David, Mitchell, Jolyon P., Strickland, Helen, Wyka, Bruce, Van Oort, Mike, Lyapustina, Svetlana

“…This study of aerodynamic mass-weighted particle size distribution (APSD) data from orally inhaled products (OIPs) investigated whether a set of simpler (than…”
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Evaluation of Nasal Inlet Ports Having Simplified Geometry for the Pharmacopeial Assessment of Mass Fraction of Dose Likely to Penetrate Beyond the Nasopharynx: a Preliminary Investigation by Williams, Gerallt, Blatchford, Chris, Mitchell, Jolyon P.

“…Nasal cavity breakthrough to the airways of the lungs is associated with nasally inhaled droplets whose size is smaller than ca. 10 μm aerodynamic diameter…”
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Relative Precision of Inhaler Aerodynamic Particle Size Distribution (APSD) Metrics by Full Resolution and Abbreviated Andersen Cascade Impactors (ACIs): Part 1 by Mitchell, Jolyon P., Nagel, Mark W., Doyle, Cathy C., Ali, Rubina S., Avvakoumova, Valentina I., Christopher, J. David, Quiroz, Jorge, Strickland, Helen, Tougas, Terrence, Lyapustina, Svetlana

“…The purpose of this study was to compare relative precision of two different abbreviated impactor measurement (AIM) systems and a traditional multi-stage…”
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Aerodynamic particle size analysis of aerosols from pressurized metered-dose inhalers: comparison of Andersen 8-stage cascade impactor, next generation pharmaceutical impactor, and model 3321 Aerodynamic Particle Sizer aerosol spectrometer by Mitchell, Jolyon P, Nagel, Mark W, Wiersema, Kimberly J, Doyle, Cathy C

“…The purpose of this research was to compare three different methods for the aerodynamic assessment of (1) chloroflurocarbon (CFC)--fluticasone propionate…”
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Laboratory Performance Testing of Aqueous Nasal Inhalation Products for Droplet/Particle Size Distribution: an Assessment from the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS) by Doub, William H., Suman, Julie M., Copley, Mark, Goodey, Adrian P., Hosseini, Sana, Mitchell, Jolyon P.

“…Although nasal inhalation products are becoming more and more important for the delivery of medicines, characterization of these products for quality control…”
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Measurement of Aerodynamic Particle Size Distribution of Orally Inhaled Products by Cascade Impactor: How to Let the Product Specification Drive the Quality Requirements of the Cascade Impactor by Roberts, Daryl L., Mitchell, Jolyon P.

“…The multi-stage inertial cascade impactor is used to determine the mass-weighted aerodynamic particle size distribution (APSD) as a critical quality attribute…”
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Clinically Relevant In Vitro Testing of Orally Inhaled Products—Bridging the Gap Between the Lab and the Patient by Mitchell, Jolyon P., Suggett, Jason, Nagel, Mark

“…ABSTRACT Current pharmacopeial methods for in vitro orally inhaled product (OIP) performance testing were developed primarily to support requirements for drug…”
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Urgent Appeal from International Society for Aerosols in Medicine (ISAM) During COVID-19: Clinical Decision Makers and Governmental Agencies Should Consider the Inhaled Route of Administration: A Statement from the ISAM Regulatory and Standardization Issues Networking Group by Mitchell, Jolyon P, Berlinski, Ariel, Canisius, Sebastian, Cipolla, David, Dolovich, Myrna B, Gonda, Igor, Hochhaus, Guenther, Kadrichu, Nani, Lyapustina, Svetlana, Mansour, Heidi M, Darquenne, Chantal, Clark, Andy R, Newhouse, Michael, Ehrmann, Stephan, Humphries, Robert, Boushey, Homer

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Remarks on the article “Effect of maximum inhalation flow and inhaled volume on formoterol drug deposition in-vitro from an Easyhaler dry-powder inhaler” by Abadelah, et al., volume 104, page 180–87 (2017) by Roberts, Daryl L., Mitchell, Jolyon P.

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Non-Pharmaceutical Techniques for Obstructive Airway Clearance Focusing on the Role of Oscillating Positive Expiratory Pressure (OPEP): A Narrative Review by Coppolo, Dominic P., Schloss, Judy, Suggett, Jason A., Mitchell, Jolyon P.

“…Mucus secretion in the lungs is a natural process that protects the airways from inhaled insoluble particle accumulation by capture and removal via the…”
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Good Practices for the Laboratory Performance Testing of Aqueous Oral Inhaled Products (OIPs): an Assessment from the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS) by Mitchell, Jolyon P., Carter, I., Christopher, J. D., Copley, M., Doub, W. H., Goodey, A., Gruenloh, C. J., Larson, B. B., Lyapustina, S., Patel, R. B., Stein, S. W., Suman, J. D.

“…Multiple sources must be consulted to determine the most appropriate procedures for the laboratory-based performance evaluation of aqueous oral inhaled…”
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Spatial aerosol flow maldistribution: A design flaw confounding the proper calibration and data interpretation of stages "0" and "1" of the Andersen eight-stage nonviable cascade impactor by Roberts, Daryl L., Mitchell, Jolyon P.

“…We introduced monodisperse calibrant particles into an eight-stage non-viable Andersen cascade impactor (ACI) operated at 28.3 L/min and separately quantified…”
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Developing Ways to Evaluate in the Laboratory How Inhalation Devices Will Be Used by Patients and Care-Givers: The Need for Clinically Appropriate Testing by Mitchell, Jolyon P., Suggett, Jason A.

“…The design of methods in the pharmaceutical compendia for the laboratory-based evaluation of orally inhaled product (OIP) performance is intentionally aimed…”
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Canadian Standards Association standard CAN/CSA/Z264.1-02:2002: a new voluntary standard for spacers and holding chambers used with pressurized metered-dose inhalers by Dolovich, Myrna B, Mitchell, Jolyon P

“…A new Canadian standard (CAN/CSA/Z264.1-02:2002) has been published with the purpose of helping to ensure the safety, efficacy and functionality of spacers…”
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Considerations for Designing In Vitro Bioequivalence (IVBE) Studies for Pressurized Metered Dose Inhalers (pMDIs) with Spacer or Valved Holding Chamber (S/VHC) Add-on Devices by Sandell, Dennis, Mitchell, Jolyon P

“…The choice of analytical test methods and associated statistical considerations are considered for the laboratory testing of pressurized metered dose…”
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Determination of Passive Dry Powder Inhaler Aerodynamic Particle Size Distribution by Multi-Stage Cascade Impactor: International Pharmaceutical Aerosol Consortium on Regulation & Science (IPAC-RS) Recommendations to Support Both Product Quality Control and Clinical Programs by Mitchell, Jolyon P., Stein, Stephen W., Doub, William, Goodey, Adrian P., Christopher, J. David, Patel, Rajni B., Tougas, Terrence P., Lyapustina, Svetlana

“…ABSTRACT The multi-stage cascade impactor (CI) is the mainstay method for the determination of the aerodynamic particle size distribution (APSD) of aerosols…”
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Development and Evaluation of a Family of Human Face and Upper Airway Models for the Laboratory Testing of Orally Inhaled Products by Nagel, Mark W., Suggett, Jason A., Coppolo, Dominic P., Mitchell, Jolyon P.

“…ABSTRACT Many orally inhaled products are supplied with a facemask instead of a mouthpiece, enabling aerosolized medication to be transferred from the inhaler…”
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Effect of Sampling Volume on Dry Powder Inhaler (DPI)-Emitted Aerosol Aerodynamic Particle Size Distributions (APSDs) Measured by the Next-Generation Pharmaceutical Impactor (NGI) and the Andersen Eight-Stage Cascade Impactor (ACI) by Mohammed, Hlack, Roberts, Daryl L., Copley, Mark, Hammond, Mark, Nichols, Steven C., Mitchell, Jolyon P.

“…Current pharmacopeial methods for testing dry powder inhalers (DPIs) require that 4.0 L be drawn through the inhaler to quantify aerodynamic particle size…”
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