Search Results - "Mitchell, J. T."

Microvesicles released from pneumolysin-stimulated lung epithelial cells carry mitochondrial cargo and suppress neutrophil oxidative burst by Letsiou, E., Teixeira Alves, L. G., Fatykhova, D., Felten, M., Mitchell, T. J., Müller-Redetzky, H.C., Hocke, A. C., Witzenrath, M.

“…Microvesicles (MVs) are cell-derived extracellular vesicles that have emerged as markers and mediators of acute lung injury (ALI). One of the most common…”
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A cutaneous lymphoma international prognostic index (CLIPi) for mycosis fungoides and Sezary syndrome by Benton, E.C, Crichton, S, Talpur, R, Agar, N.S, Fields, P.A, Wedgeworth, E, Mitchell, T.J, Cox, M, Ferreira, S, Liu, P, Robson, A, Calonje, E, Stefanato, C.M, Wilkins, B, Scarisbrick, J, Wain, E.M, Child, F, Morris, S, Duvic, M, Whittaker, S.J

“…Abstract Background There is no prognostic index for primary cutaneous T-cell lymphomas such as mycosis fungoides (MF) and Sezary syndrome (SS). Method Two…”
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Pneumolysin activates neutrophil extracellular trap formation by Nel, J. G., Theron, A. J., Durandt, C., Tintinger, G. R., Pool, R., Mitchell, T. J., Feldman, C., Anderson, R.

“…Summary The primary objective of the current study was to investigate the potential of the pneumococcal toxin, pneumolysin (Ply), to activate neutrophil…”
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Breast cancer patients' clinical outcome measures are associated with Src kinase family member expression by Elsberger, B, Fullerton, R, Zino, S, Jordan, F, Mitchell, T J, Brunton, V G, Mallon, E A, Shiels, P G, Edwards, J

“…Background: This study determined mRNA expression levels for Src kinase family (SFK) members in breast tissue specimens and assessed protein expression levels…”
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Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro by Anderson, R., Steel, H. C., Cockeran, R., von Gottberg, A., de Gouveia, L., Klugman, K. P., Mitchell, T. J., Feldman, C.

“…Objectives To compare the effects of subinhibitory concentrations of amoxicillin, ceftriaxone, azithromycin, clarithromycin, erythromycin, telithromycin,…”
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Partial Complementation of Sinorhizobium meliloti bacA Mutant Phenotypes by the Mycobacterium tuberculosis BacA Protein by Arnold, M. F. F, Haag, A. F, Capewell, S, Boshoff, H. I, James, E. K, McDonald, R, Mair, I, Mitchell, A. M, Kerscher, B, Mitchell, T. J, Mergaert, P, Barry, C. E, Scocchi, M, Zanda, M, Campopiano, D. J, Ferguson, G. P

“…The Sinorhizobium meliloti BacA ABC transporter protein plays an important role in its nodulating symbiosis with the legume alfalfa (Medicago sativa). The…”
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Constitutive activation of STAT3 in Sézary syndrome is independent of SHP-1 by McKenzie, R C T, Jones, C L, Tosi, I, Caesar, J A, Whittaker, S J, Mitchell, T J

“…Constitutive and persistent activation of STAT3 has been implicated in the pathogenesis of many malignancies. Studies of CTCL cell lines have previously…”
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A two‐component system that controls the expression of pneumococcal surface antigen A (PsaA) and regulates virulence and resistance to oxidative stress in Streptococcus pneumoniae by McCluskey, J., Hinds, J., Husain, S., Witney, A., Mitchell, T. J.

“…Summary Recent genomic‐based studies have identified 13 two‐component signal transduction systems (TCS) in Streptococcus pneumoniae. Bacterial TCSs are…”
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Temporal Analysis of Invasive Pneumococcal Clones from Scotland Illustrates Fluctuations in Diversity of Serotype and Genotype in the Absence of Pneumococcal Conjugate Vaccine by Jefferies, J.M, Smith, A.J, Edwards, G.F.S, McMenamin, J, Mitchell, T.J, Clarke, S.C

“…In September 2006, the seven-valent pneumococcal conjugate vaccine (PCV7; Prevenar) was introduced into the childhood vaccination schedule in the United…”
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The Ami-AliA/AliB Permease of Streptococcus pneumoniae Is Involved in Nasopharyngeal Colonization but Not in Invasive Disease by KERR, A. R, ADRIAN, P. V, ESTEVAO, S, DE GROOT, R, ALLOING, G, CLAVERYS, J.-P, MITCHELL, T. J, HERMANS, P. W. M

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Leukocyte-Rich Platelet-Rich Plasma Is Predominantly Anti-inflammatory Compared With Leukocyte-Poor Platelet-Rich Plasma in Patients With Mild-Moderate Knee Osteoarthritis: A Prospective, Descriptive Laboratory Study by Jayaram, Prathap, Mitchell, Parker J.T., Shybut, Theodore B., Moseley, Bruce J., Lee, Brendan

“…Background: Platelet-rich plasma (PRP) has been used extensively in clinical practice to treat patients with symptomatic knee osteoarthritis (OA)…”
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Role of two-component systems in the virulence of Streptococcus pneumoniae by Paterson, G. K, Blue, C. E, Mitchell, T. J

“…Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK Correspondence T. J. Mitchell…”
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Pneumolysin induces release of matrix metalloproteinase-8 and -9 from human neutrophils by Cockeran, R, Mitchell, T. J, Feldman, C, Anderson, R

“…The research question addressed in the current study was: does the pneumococcal pore-forming toxin, pneumolysin, mobilise matrix metalloproteinase (MMP) -8 and…”
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Streptococcus pneumoniae: virulence factors and variation by Mitchell, A.M., Mitchell, T.J.

“…Streptococcus pneumoniae is a major pathogen of humans, causing diseases such as pneumonia and meningitis. The organism produces several virulence factors that…”
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Characterization of the interactions of the pneumolysoid, Δ6 PLY, with human neutrophils in vitro by Cockeran, R, Steel, H.C, Theron, A.J, Mitchell, T.J, Feldman, C, Anderson, R

“…Highlights ► Δ6 PLY is a prototype pneumococcal vaccine candidate. ► Δ6 PLY fails to produce a pro-inflammatory response (unlike pneumolysin), underscores its…”
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Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae by Anderson, R., Steel, H. C., Cockeran, R., Smith, A. M., von Gottberg, A., de Gouveia, L., Brink, A., Klugman, K. P., Mitchell, T. J., Feldman, C.

“…Objectives To investigate the effects of clarithromycin (0.01–0.5 mg/L) alone or in combination with ceftriaxone (0.1 and 0.25 mg/L) on pneumolysin production…”
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ZmpB, a Novel Virulence Factor of Streptococcus pneumoniae That Induces Tumor Necrosis Factor Alpha Production in the Respiratory Tract by BLUE, C. E, PATERSON, G. K, KERR, A. R, BERGE, M, CLAVERYS, J. P, MITCHELL, T. J

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Identification of novel pneumolysin alleles from paediatric carriage isolates of Streptococcus pneumoniae by JEFFERIES, J. M. C, TOCHEVA, A. S, RUBERY, H, BENNETT, J, GARLAND, J, CHRISTODOULIDES, M, FAUST, S. N, SMITH, A, MITCHELL, T. J, CLARKE, S. C

“…Pneumolysin (Ply) is a major virulence factor of Streptococcus pneumoniae and is produced by all known clinical isolates of pneumococci. Pneumolysin toxoids…”
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Development of a multiplexed bead-based immunoassay for the simultaneous detection of antibodies to 17 pneumococcal proteins by Shoma, S, Verkaik, N. J, de Vogel, C. P, Hermans, P. W. M, van Selm, S, Mitchell, T. J, van Roosmalen, M, Hossain, S, Rahman, M, Endtz, H. Ph, van Wamel, W. J. B, van Belkum, A

“…Presently, several pneumococcal proteins are being evaluated as potential vaccine candidates. Here, we gather novel insights in the immunogenicity of PLY,…”
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Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide by de Saizieu, A, Gardès, C, Flint, N, Wagner, C, Kamber, M, Mitchell, T J, Keck, W, Amrein, K E, Lange, R

“…We have identified in the Streptococcus pneumoniae genome sequence a two-component system (TCS13, Blp [bacteriocin-like peptide]) which is closely related to…”
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