Search Results - "Mitchell, G. S."

Unexpected benefits of intermittent hypoxia: enhanced respiratory and nonrespiratory motor function by Dale, E A, Ben Mabrouk, F, Mitchell, G S

“…Intermittent hypoxia (IH) is most often thought of for its role in morbidity associated with sleep-disordered breathing, including central nervous system…”
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Optical imaging of Cerenkov light generation from positron-emitting radiotracers by Robertson, R, Germanos, M S, Li, C, Mitchell, G S, Cherry, S R, Silva, M D

“…Radiotracers labeled with high-energy positron emitters, such as those commonly used for positron emission tomography studies, emit visible light immediately…”
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Spinal 5-HT7 receptors induce phrenic motor facilitation via EPAC-mTORC1 signaling by Fields, D P, Springborn, S R, Mitchell, G S

“…Spinal serotonin type 7 (5-HT7) receptors elicit complex effects on motor activity. Whereas 5-HT7 receptor activation gives rise to long-lasting phrenic motor…”
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Episodic spinal serotonin receptor activation elicits long-lasting phrenic motor facilitation by an NADPH oxidase-dependent mechanism by MacFarlane, P. M., Mitchell, G. S.

“…Phrenic long-term facilitation (pLTF) is a serotonin (5-HT)-dependent augmentation of phrenic motor output induced by acute intermittent hypoxia (AIH)…”
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Spinal 5-HT7 receptors and protein kinase A constrain intermittent hypoxia-induced phrenic long-term facilitation by Hoffman, M.S, Mitchell, G.S

“…Highlights • Spinal 5-HT7 receptor inhibition enhances pLTF after AIH. • Spinal PKA inhibition enhances pLTF. • Spinal PKA activation blunts pLTF. • 5-HT7…”
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Diaphragm long-term facilitation following acute intermittent hypoxia during wakefulness and sleep by TERADA, J, MITCHELL, G. S

“…Acute intermittent hypoxia (AIH) elicits a form of respiratory plasticity known as long-term facilitation (LTF). Here, we tested four hypotheses in…”
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Systemic LPS induces spinal inflammatory gene expression and impairs phrenic long-term facilitation following acute intermittent hypoxia by Huxtable, A G, Smith, S M C, Vinit, S, Watters, J J, Mitchell, G S

“…Although systemic inflammation occurs in most pathological conditions that challenge the neural control of breathing, little is known concerning the impact of…”
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Serotonin 2A and 2B receptor-induced phrenic motor facilitation: differential requirement for spinal NADPH oxidase activity by MacFarlane, P.M, Vinit, S, Mitchell, G.S

“…Abstract Acute intermittent hypoxia (AIH) facilitates phrenic motor output by a mechanism that requires spinal serotonin (type 2) receptor activation, NADPH…”
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Spinal adenosine A2A receptor inhibition enhances phrenic long term facilitation following acute intermittent hypoxia by Hoffman, M. S., Golder, F. J., Mahamed, S., Mitchell, G. S.

“…Phrenic long term facilitation (pLTF) is a form of respiratory plasticity induced by acute intermittent hypoxia. pLTF requires spinal serotonin receptor…”
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Daily acute intermittent hypoxia improves breathing function with acute and chronic spinal injury via distinct mechanisms by Dougherty, B.J, Terada, J, Springborn, S.R, Vinit, S, MacFarlane, P.M, Mitchell, G.S

“…Highlights • Daily acute intermittent hypoxia (dAIH) improves breathing function following cervical spinal cord injury (C2 hemisection; C2Hs) in rats. •…”
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Methadone treatment of arrestees: A randomized clinical trial by Schwartz, R.P., Kelly, S.M., Mitchell, S.G., O’Grady, K.E., Sharma, A., Jaffe, J.H.

“…•Starting methadone treatment in jail promoted post-release treatment entry.•It was not associated with less post-release opioid use compared to…”
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The fate of nanocarriers as nanomedicines in vivo: important considerations and biological barriers to overcome by Moros, M, Mitchell, S G, Grazú, V, de la Fuente, J M

“…Many pharmaceuticals on the market suffer from two significant limitations to their activity: lack of specificity toward the pathological site and poor aqueous…”
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Spinal nNOS regulates phrenic motor facilitation by a 5-HT2B receptor- and NADPH oxidase-dependent mechanism by MacFarlane, P.M, Vinit, S, Mitchell, G.S

“…Highlights • Neuronal nitric oxide synthase is necessary for phrenic long-term facilitation (pLTF) following acute intermittent hypoxia. • Episodic spinal NO…”
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Breathing patterns after mid-cervical spinal contusion in rats by Golder, F.J., Fuller, D.D., Lovett-Barr, M.R., Vinit, S., Resnick, D.K., Mitchell, G.S.

“…Respiratory failure is the leading cause of death after cervical spinal injury. We hypothesized that incomplete cervical spinal injuries would alter…”
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NADPH oxidase activity is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation by MacFarlane, P. M., Satriotomo, I., Windelborn, J. A., Mitchell, G. S.

“…Phrenic long-term facilitation (pLTF) following acute intermittent hypoxia (AIH) is a form of spinal, serotonin-dependent synaptic plasticity that requires…”
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Respiratory long-term facilitation following intermittent hypoxia requires reactive oxygen species formation by MacFarlane, P.M, Mitchell, G.S

“…Abstract Acute intermittent hypoxia (AIH) elicits a form of respiratory plasticity known as long-term facilitation (LTF). LTF is a progressive and sustained…”
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Episodic but not continuous hypoxia elicits long-term facilitation of phrenic motor output in rats by Baker, T. L., Mitchell, G. S.

“…Intermittent hypoxia elicits long-term facilitation (LTF) of phrenic motor output in anaesthetized rats. We tested the hypothesis that an equal cumulative…”
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HIV-Risk Behavior Among Adults with Opioid Use Disorder During 12 Months Following Pre-trial Detention: Results from a Randomized Trial of Methadone Treatment by Mitchell, M. M., Kelly, S. M., O’Grady, K. E., Jaffe, J. H., Mitchell, S. G., Schwartz, R. P.

“…This was a three group randomized clinical trial of interim methadone and patient navigation involving 225 pre-trial detainees with opioid use disorder in…”
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Conversion from testosterone to oestradiol is required to modulate respiratory long-term facilitation in male rats by Zabka, A. G., Mitchell, G. S., Behan, M.

“…Sex hormones modulate plasticity in the central nervous system, including respiratory long-term facilitation (LTF), a form of serotonin-dependent respiratory…”
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Sleep state dependence of ventilatory long-term facilitation following acute intermittent hypoxia in Lewis rats by NAKAMURA, A, OLSON, E. B, TERADA, J, WENNINGER, J. M, BISGARD, G. E, MITCHELL, G. S

“…Ventilatory long-term facilitation (vLTF) is a form of respiratory plasticity induced by acute intermittent hypoxia (AIH). Although vLTF has been reported in…”
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