Search Results - "Mitchell, Dylan C"

Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries by Kuljanin, Miljan, Mitchell, Dylan C., Schweppe, Devin K., Gikandi, Ajami S., Nusinow, David P., Bulloch, Nathan J., Vinogradova, Ekaterina V., Wilson, David L., Kool, Eric T., Mancias, Joseph D., Cravatt, Benjamin F., Gygi, Steven P.

“…Current methods used for measuring amino acid side-chain reactivity lack the throughput needed to screen large chemical libraries for interactions across the…”
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Proteome-wide mapping of short-lived proteins in human cells by Li, Jiaming, Cai, Zhenying, Vaites, Laura Pontano, Shen, Ning, Mitchell, Dylan C., Huttlin, Edward L., Paulo, Joao A., Harry, Brian L., Gygi, Steven P.

“…Rapid protein degradation enables cells to quickly modulate protein abundance. Dysregulation of short-lived proteins plays essential roles in disease…”
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A proteome-wide atlas of drug mechanism of action by Mitchell, Dylan C., Kuljanin, Miljan, Li, Jiaming, Van Vranken, Jonathan G., Bulloch, Nathan, Schweppe, Devin K., Huttlin, Edward L., Gygi, Steven P.

“…Defining the cellular response to pharmacological agents is critical for understanding the mechanism of action of small molecule perturbagens. Here, we…”
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Assessing target engagement using proteome-wide solvent shift assays by Van Vranken, Jonathan G, Li, Jiaming, Mitchell, Dylan C, Navarrete-Perea, José, Gygi, Steven P

“…Recent advances in mass spectrometry (MS) have enabled quantitative proteomics to become a powerful tool in the field of drug discovery, especially when…”
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The RNA-binding protein SART3 promotes miR-34a biogenesis and G1 cell cycle arrest in lung cancer cells by Sherman, Emily J., Mitchell, Dylan C., Garner, Amanda L.

“…MicroRNAs (miRNAs or miRs) are small, noncoding RNAs that are implicated in the regulation of most biological processes. Global miRNA biogenesis is altered in…”
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Cyclin‐dependent kinase 4 inhibits the translational repressor 4E‐BP1 to promote cap‐dependent translation during mitosis–G1 transition by Mitchell, Dylan C., Menon, Arya, Garner, Amanda L.

“…Phosphorylation of translational repressor eukaryotic translation initiation factor 4E (eIF4E)‐binding protein 1 (4E‐BP1) controls the initiation of…”
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MNK-driven eIF4E phosphorylation regulates the fibrogenic transformation of mesenchymal cells and chronic lung allograft dysfunction by Walker, Natalie M, Ibuki, Yuta, McLinden, A Patrick, Misumi, Keizo, Mitchell, Dylan C, Kleer, Gabriel G, Lock, Alison M, Vittal, Ragini, Sonenberg, Nahum, Garner, Amanda L, Lama, Vibha N

“…Tissue fibrosis remains unamenable to meaningful therapeutic interventions and is the primary cause of chronic graft failure after organ transplantation…”
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The Arg/N-degron pathway targets transcription factors and regulates specific genes by Vua, Tri T. M., Mitchell, Dylan C., Gygi, Steven P., Varshavsky, Alexander

“…The Arg/N-degron pathway targets proteins for degradation by recognizing their N-terminal or internal degrons. Our previous work produced double-knockout…”
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High-Throughput Chemical Probing of Full-Length Protein–Protein Interactions by Song, James M, Menon, Arya, Mitchell, Dylan C, Johnson, Oleta T, Garner, Amanda L

“…Human biology is regulated by a complex network of protein–protein interactions (PPIs), and disruption of this network has been implicated in many diseases…”
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The RNA-binding protein SART3 promotes miR-34a biogenesis and G 1 cell cycle arrest in lung cancer cells by Sherman, Emily J, Mitchell, Dylan C, Garner, Amanda L

“…MicroRNAs (miRNAs or miRs) are small, noncoding RNAs that are implicated in the regulation of most biological processes. Global miRNA biogenesis is altered in…”
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