Search Results - "Mitchell, Dana K"

New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types by Gampala, Silpa, Moon, Hye-ran, Wireman, Randall, Peil, Jacqueline, Kiran, Sonia, Mitchell, Dana K., Brewster, Kylee, Mang, Henry, Masters, Andi, Bach, Christine, Smith-Kinnamen, Whitney, Doud, Emma H., Rai, Ratan, Mosley, Amber L., Quinney, Sara K., Clapp, D. Wade, Hamdouchi, Chafiq, Wikel, James, Zhang, Chi, Han, Bumsoo, Georgiadis, Millie M., Kelley, Mark R., Fishel, Melissa L.

“…AP endonuclease-1/Redox factor-1 (APE1/Ref-1 or Ref-1) is a multifunctional protein that is overexpressed in most aggressive cancers and impacts various cancer…”
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Neratinib, a pan ERBB/HER inhibitor, restores sensitivity of PTEN -null, BRAFV600E melanoma to BRAF/MEK inhibition by DuBose, Evan, Bevill, Samantha M, Mitchell, Dana K, Sciaky, Noah, Golitz, Brian T, Dixon, Shelley A H, Rhodes, Steven D, Bear, James E, Johnson, Gary L, Angus, Steven P

“…Approximately 50% of melanomas harbor an activating mutation. Standard of care involves a combination of inhibitors targeting mutant BRAF and MEK1/2, the…”
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SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA‐deficient cells by Chan, Ka‐Kui, Abdul‐Sater, Zahi, Sheth, Aditya, Mitchell, Dana K., Sharma, Richa, Edwards, Donna M., He, Ying, Nalepa, Grzegorz, Rhodes, Steven D., Clapp, D. Wade, Sierra Potchanant, Elizabeth A.

“…The Fanconi anemia (FA) pathway safeguards genomic stability through cell cycle regulation and DNA damage repair. The canonical tumor suppressive role of FA…”
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Mitotic Errors Promote Genomic Instability and Leukemia in a Novel Mouse Model of Fanconi Anemia by Edwards, Donna M., Mitchell, Dana K., Abdul-Sater, Zahi, Chan, Ka-Kui, Sun, Zejin, Sheth, Aditya, He, Ying, Jiang, Li, Yuan, Jin, Sharma, Richa, Czader, Magdalena, Chin, Pei-Ju, Liu, Yie, de Cárcer, Guillermo, Nalepa, Grzegorz, Broxmeyer, Hal E., Clapp, D. Wade, Sierra Potchanant, Elizabeth A.

“…Fanconi anemia (FA) is a disease of genomic instability and cancer. In addition to DNA damage repair, FA pathway proteins are now known to be critical for…”
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Genetic Testing Guidelines Impact Care in Newborns with Congenital Heart Defects by Durbin, Matthew D., Fairman, Korre, Helvaty, Lindsey R., Huang, Manyan, Li, Ming, Abreu, Daniel, Geddes, Gabrielle C., Helm, Benjamin M., Landis, Benjamin J., McEntire, Alexis, Mitchell, Dana K., Ware, Stephanie M.

“…To evaluate genetic evaluation practices in newborns with the most common birth defect, congenital heart defects (CHD), we determined the prevalence and the…”
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Spatial Gene-Expression Profiling Unveils Immuno-oncogenic Programs of NF1-Associated Peripheral Nerve Sheath Tumor Progression by Mitchell, Dana K, Burgess, Breanne, White, Emily E, Smith, Abbi E, Sierra Potchanant, Elizabeth A, Mang, Henry, Hickey, Brooke E, Lu, Qingbo, Qian, Shaomin, Bessler, Waylan, Li, Xiaohong, Jiang, Li, Brewster, Kylee, Temm, Constance, Horvai, Andrew, Albright, Eric A, Fishel, Melissa L, Pratilas, Christine A, Angus, Steven P, Clapp, D Wade, Rhodes, Steven D

“…Plexiform neurofibromas (PNF) are benign peripheral nerve sheath tumors (PNST) associated with neurofibromatosis type 1 (NF1). Despite similar histologic…”
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Correction: Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma by Flint, Alyssa C, Mitchell, Dana K, Angus, Steven P, Smith, Abbi E, Bessler, Waylan, Jiang, Li, Mang, Henry, Li, Xiaohong, Lu, Qingbo, Rodriguez, Brooke, Sandusky, George E, Masters, Andi R, Zhang, Chi, Dang, Pengtao, Koenig, Jenna, Johnson, Gary L, Shen, Weihua, Liu, Jiangang, Aggarwal, Amit, Donoho, Gregory P, Willard, Melinda D, Bhagwat, Shripad V, Clapp, D Wade, Rhodes, Steven D

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Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma by Flint, Alyssa C, Mitchell, Dana K, Angus, Steven P, Smith, Abbi E, Bessler, Waylan, Jiang, Li, Mang, Henry, Li, Xiaohong, Lu, Qingbo, Rodriguez, Brooke, Sandusky, George E, Masters, Andi R, Zhang, Chi, Dang, Pengtao, Koenig, Jenna, Johnson, Gary L, Shen, Weihua, Liu, Jiangang, Aggarwal, Amit, Donoho, Gregory P, Willard, Melinda D, Bhagwat, Shripad V, Clapp, D Wade, Rhodes, Steven D

“…Plexiform neurofibromas (PNF) are peripheral nerve sheath tumors that cause significant morbidity in persons with neurofibromatosis type 1 (NF1), yet treatment…”
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Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 1 by Mund, Julie A, Park, SuJung, Smith, Abbi E, He, Yongzheng, Jiang, Li, Hawley, Eric, Roberson, Michelle J, Mitchell, Dana K, Abu-Sultanah, Mohannad, Yuan, Jin, Bessler, Waylan K, Sandusky, George, Chen, Shi, Zhang, Chi, Rhodes, Steven D, Clapp, D Wade

“…Neurofibromatosis type 1 (NF1) is a common cancer predisposition syndrome caused by mutations in the tumor suppressor gene. encodes neurofibromin, a…”
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Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 17 by Mund, Julie A., Park, SuJung, Smith, Abbi E., He, Yongzheng, Jiang, Li, Hawley, Eric, Roberson, Michelle J., Mitchell, Dana K., Abu-Sultanah, Mohannad, Yuan, Jin, Bessler, Waylan K., Sandusky, George, Chen, Shi, Zhang, Chi, Rhodes, Steven D., Clapp, D. Wade

“…Neurofibromatosis type 1 (NF1) is a common cancer predisposition syndrome caused by mutations in the NF1 tumor suppressor gene. NF1 encodes neurofibromin, a…”
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Correction: Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 17 by Mund, Julie A., Park, SuJung, Smith, Abbi E., He, Yongzheng, Jiang, Li, Hawley, Eric, Roberson, Michelle J., Mitchell, Dana K., Abu-Sultanah, Mohannad, Yuan, Jin, Bessler, Waylan K., Sandusky, George, Chen, Shi, Zhang, Chi, Rhodes, Steven D., Clapp, D.Wade

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A multicenter cross-sectional study in infants with congenital heart defects demonstrates high diagnostic yield of genetic testing but variable evaluation practices by Durbin, Matthew D., Helvaty, Lindsey R., Li, Ming, Border, William, Fitzgerald-Butt, Sara, Garg, Vidu, Geddes, Gabrielle C., Helm, Benjamin M., Lalani, Seema R., McBride, Kim L., McEntire, Alexis, Mitchell, Dana K., Murali, Chaya N., Wechsler, Stephanie B., Landis, Benjamin J., Ware, Stephanie M.

“…For patients with congenital heart disease (CHD), the most common birth defect, genetic evaluation is not universally accepted, and current practices are…”
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Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma by Flint, Alyssa C., Mitchell, Dana K., Angus, Steven P., Smith, Abbi E., Bessler, Waylan, Jiang, Li, Mang, Henry, Li, Xiaohong, Lu, Qingbo, Rodriguez, Brooke, Sandusky, George E., Masters, Andi R., Zhang, Chi, Dang, Pengtao, Koenig, Jenna, Johnson, Gary L., Shen, Weihua, Liu, Jiangang, Aggarwal, Amit, Donoho, Gregory P., Willard, Melinda D., Bhagwat, Shripad V., Wade Clapp, D., Rhodes, Steven D.

“…Plexiform neurofibromas (PNF) represent a major source of morbidity in persons with neurofibromatosis type 1 (NF1). There remains an unmet need to develop new…”
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Abstract B072: Pharmacological depletion of fibrinogen suppresses the growth of primary tumors and liver metastasis of pancreatic cancer by Chowdhury, Nayela N, Mitchell, Dana K, Kangro, Kadri, Eldridge, Kierra, Abrahams, Sara, Ferraresso, Francesca, Juang, Lih J, Gampala, Silpa, Brewster, Kylee, Revenko, Alexey, Kastrup, Christian, Territo, Paul R, Clapp, D Wade, Belgodere, Jorge A, Han, Bumsoo, Wolberg, Alisa S, Zhang, Chi, Flick, Matthew J, Fishel, Melissa L

“…Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is a highly metastatic disease often linked to the dysregulated activation of both coagulation and…”
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